Ocular Volume Change per Minute with Ocular Pneumoplethysmography

Gee, William; Reed, James F.

doi:10.1159/000055558

Cited by 4 publications

(4 citation statements)

References 7 publications

(8 reference statements)

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“…However, we note a significant difference between the magnitude of the POBF values reported by Gee et al [20] [24]). These OBF values can be expressed per 1.9 g of vascularized ocular tissue [22] and compared with 'universally accepted figures of 50-55 ml/100 g/min for the brain' [22].…”

Section: Discussioncontrasting

confidence: 68%

“…Then the blood flow to the eye has a ratio to the blood flow to the brain of 0.8-0.9 (this work), 0.6-0.8 (previous OBF Tonograph [16,17]), 1.1 (microspheres [21]), 1.3-1.5 (OPG-G [22][23][24]) and 19.3-23.5 (OPG-G [20]). A new mathematical formulation has been used for the recent OPG-G POBF calculations by Gee et al [20], without a reconciliation with the former OPG-G [22][23][24] values.…”

Section: Discussionmentioning

confidence: 95%

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Gender and Age Effects on Pulsatile Ocular Blood Flow

et al. 2003

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Purpose: To examine gender and age effects on pulsatile ocular blood flow (POBF). Methods: Normal subjects, 152 females and 107 males, were separated into younger (40–50) and older (50–60) age groups. Results: For younger women, mean POBF (15.3 ± 3.7 µl/s) was significantly different (p < 0.01) than for older women (13.8 ± 3.5 µl/s), younger men (13.2 ± 3.3 µl/s), and older men (13.3 ± 3.1 µl/s). The mean POBFs for each of the latter three groups were not significantly different (p > 0.41) from one another. The four groups showed no significant differences in intraocular pressure (p > 0.07) or refraction (p > 0.46). Pulse rate for younger women was significantly higher (p < 0.05) than for the older two groups, but there were no significant pulse rate differences (p > 0.08) between other groups. POBF was not correlated with IOP (r² < 0.04), refraction (r² < 0.009) or pulse rate (r² < 0.04). Conclusion: Gender and age play an important role in POBF.

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Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 95%

Gender and Age Effects on Pulsatile Ocular Blood Flow

et al. 2003

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“…A recent report contains the bilateral ocular volume change per minute, before and after carotid endarterectomy, in 1737 patients. 10 Of particular interest, in the latter report, is the considerable dif-ference in ocular hemodynamics that exists between male and female patients.…”

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confidence: 89%

Negative genetic risk factor for abdominal aortic aneurysm: HLA-DQ3, a Japanese study

Hirose

Tilson

1999

Journal of Vascular Surgery

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Abdominal aortic aneurysms (AAAs) may be related to specific HLA alleles. 1,2 We have reported that HLA-DR2( 15) is a positive risk factor for nonspecific infrarenal AAAs in Japan. 3 HLA class II antigens are further divided into DR and DQ antigens, which are expressed independently on the antigen presenting cells. Some DQ alleles are reported to be associated with autoimmune diseases, such as Hashimoto's thyroiditis. 4 This study was performed to determine whether specific HLA DQ alleles are associated with AAA. METHODPeripheral blood samples were obtained from 36 patients with AAAs and from 39 volunteers, most of whom were among the subjects (all Japanese) on whom we have previously reported an association with HLA-DR2(15). The age, sex, and associated medical problems of the two groups were similar (data not shown). DQ antigen typing was performed at the Mitsubishi Biochemical Laboratory (MBC, Tokyo, Japan) with a serologic technique. 5 The homozygosity was identified if only one antigen was identified from an individual. The typing tests were repeated to confirm that the results were not simple serologic reagent error. The frequency of antigens of HLA-DQ alleles were compared with the χ 2 test. RESULTSThe AAA group consisted of 30 men and six women, with an age distribution from 47 to 85 years (mean, 71.8 years). Three AAAs were ruptured, and the others were intact infrarenal AAAs with diameters of 4 cm to 10.0 cm (mean, 5.7 cm). The distributions of HLA-DQ are shown in Table I. The frequency of HLA-DQ3 antigen was significantly decreased in the AAA group (22.2% in AAAs and 41.0% in controls), with a P value of less than .02. Homozygous DQ3 was observed in five control subjects but was not observed in relation to the AAA group. DISCUSSIONThese study results suggested that HLA-DQ3 antigen appeared to have a protective effect in relation to AAA. However, the relation of DQ3 and DR2(15) remained unknown. Suppressive effects of certain DQ alleles have been reported in other autoimmune conditions, like Hashimoto's thyroiditis and insulin-dependent diabetes mellitus. 6 When DR status is included in the analysis of these groups of patients with AAA and control subjects, the data further suggest that DR2(15) promotes AAA disease and DQ3 protects. If DR2(15) positive and DQ3 negative are considered to be the high-risk serotypes, then 89% (32 of 36) of the patients with AAA had one of these features as compared with 41% (16 of 39) of the control subjects (P < .0001).

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“…For this purpose, methods such as fundus fluorescein angiography, iris fluorescein angiography, indocyanine green angiography, arteriography, venography, ophthalmodynamometry, pneumoplethysmography, suction-cup dynamometry, oculooscillodynamography, marked microspheres, and laser Doppler velocitometry have been used previously. 6,[10][11][12][13][14][15][16] More recently, color Doppler ultrasonography has been found to be beneficial in investigating the changes of retrobulbar blood flow after some ophthalmic surgical procedures such as scleral buckling, trabeculectomy, and optic nerve decompression. [17][18][19][20] Although anterior ciliary arteries and anterior segment circulation cannot be assessed with conventional Doppler equipment, potential alterations in retrobulbar blood flow after strabismus surgery can be evaluated by this method.…”

mentioning

confidence: 99%