Oculoplastic aspects of ocular oncology

Abstract

It is estimated that 5-10% of all cutaneous malignancies involve the periocular region and management of periocular skin cancers account for a significant proportion of the oculoplastic surgeon's workload. Epithelial tumours are most frequently encountered, including basal cell carcinoma, squamous cell carcinoma, and sebaceous gland carcinoma, in decreasing order of frequency. Non-epithelial tumours, such as cutaneous melanoma and Merkel cell carcinoma, rarely involve the ocular adnexae. Although non-surgical treatments for periocular malignancies are gaining in popularity, surgery remains the main treatment modality and has as its main aims tumour clearance, restoration of the eyelid function, protection of the ocular surface, and achieving a good cosmetic outcome. The purpose of this article is to review the management of malignant periocular tumours, with particular emphasis on surgical management.

Periocular Skin Cancer in Solid Organ Transplant Recipients

“…2,9,18 Even in patients with intact immune systems, periocular cutaneous malignancies typically present with few signs or symptoms, often delaying diagnosis. 23,24 Cutaneous eyelid malignancies may result in globe exposure, nerve damage, vision loss, globe loss, or loss of life. 9,23,24 Because transplant recipients experience skin cancers at a younger age, with increased incidence and aggressiveness, 2 periocular lesions may produce a particularly significant impact on quality of life.…”

Eyelid skin cancer: еpidemiology, prognosis

“…4). Это под-тверждают сведения в специальной литературе: среди европеоидной расы частота БКР кожи век достигает 90-95 % [20]. Как показывает анализ нашего материала, рак ко-жи век, который можно диагностировать визуально, в стадии Т1 и Т2 выявляют в Москве только в 65,7 % случаев, а в стадии Т1, когда больной может быть полностью излечен от опухоли, -всего в 34 %.…”

Applications of stem cell biology to oculoplastic surgery

“…Surgery remains the best treatment modality for these periocular tumors, but several reasons may prevent this from being the best choice of action [25]. Therefore, multiple non-surgical treatments have been used for these cases, including radiotherapy, cryotherapy, 5-fluorouracil, imiquimod, photodynamic therapy, and hedgehog signaling inhibitors [26]. …”