“…If the biopsy material was sent to the lab the findings would be granulomatous tissue, pseudoepitheliomatous hyperplasia and chronic inflammation [23][24][25][26]. Usually it can misguide the diagnostics, as there are other entities that can generate fistulas, pyogenic granuloma, salivary gland fistulas, congenital fistulas, infected cysts, deep mycosis infections, actinomycosis, thyroid cyst, pustules, furuncles, reactions to foreign bodies, skin carcinomas such as basal cell and squamous cancer, inverted follicular keratosis, dacryocystitis, suppurative lymphadenitis, tertiary syphilis and tuberculosis [27,28]. Rarely periapical abscess and fistulas generate complications, as mentioned before, osteomyelitis and sepsis [6].…”