Odontogenic keratocyst with granular cell changes: A distinctive finding

Deshmukh, Revati; Bavle, Radhika M; Deo, Priya Nimish; Chavan, Surekha

doi:10.4103/jomfp.jomfp_152_19

Cited by 14 publications

(3 citation statements)

References 20 publications

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“…The community of microorganisms that live upon or within a host are referred to as the microbiota. The human microbiota includes bacteria, fungi, viruses, and archaea that colonize the surface or deep layers of the skin (skin microbiota), the mouth (oral microbiota), the vagina (vaginal microbiota), and the digestive tract (gut microbiota) (1). The human microbiota has received increasing attention in numerous research fields over the last 15 years.…”

Section: Introductionmentioning

confidence: 99%

Microbiome or Infections: Amyloid-Containing Biofilms as a Trigger for Complex Human Diseases

et al. 2021

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The human microbiota is the community of microorganisms that live upon or within their human host. The microbiota consists of various microorganisms including bacteria, fungi, viruses, and archaea; the gut microbiota is comprised mostly of bacteria. Many bacterial species within the gut microbiome grow as biofilms, which are multicellular communities embedded in an extracellular matrix. Studies have shown that the relative abundances of bacterial species, and therefore biofilms and bacterial byproducts, change during progression of a variety of human diseases including gastrointestinal, autoimmune, neurodegenerative, and cancer. Studies have shown the location and proximity of the biofilms within the gastrointestinal tract might impact disease outcome. Gram-negative enteric bacteria secrete the amyloid curli, which makes up as much as 85% of the extracellular matrix of enteric biofilms. Curli mediates cell-cell attachment and attachment to various surfaces including extracellular matrix components such as fibronectin and laminin. Structurally, curli is strikingly similar to pathological and immunomodulatory human amyloids such as amyloid-β, which has been implicated in Alzheimer's disease, α-synuclein, which is involved in Parkinson's disease, and serum amyloid A, which is secreted during the acute phase of inflammation. The immune system recognizes both bacterial amyloid curli and human amyloids utilizing the same receptors, so curli also induces inflammation. Moreover, recent work indicates that curli can participate in the self-assembly process of pathological human amyloids. Curli is found within biofilms of commensal enteric bacteria as well as invasive pathogens; therefore, evidence suggests that curli contributes to complex human diseases. In this review, we summarize the recent findings on how bacterial biofilms containing curli participate in the pathological and immunological processes in gastrointestinal diseases, systemic autoimmune diseases, and neurodegenerative diseases.

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Section: Introductionmentioning

confidence: 99%

Microbiome or Infections: Amyloid-Containing Biofilms as a Trigger for Complex Human Diseases

et al. 2021

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“…The oral cavity harbors a diverse microbiome and the second largest number of microorganisms after the gut (1), with ∼500-700 species (2). There are many distinct niches in the oral cavity that characterize a complex habitat providing shedding (soft tissues/mucosa) and non-shedding (teeth) surfaces for microbial colonization (1). The dysbiotic state of the oral microbiome triggers the most common biofilm-mediated oral diseases in children: caries and gingivitis (2).…”

Section: Introductionmentioning

confidence: 99%

“…Advances in the knowledge of how host-associated microbial communities promote or protect against pathogenic microbes and how microorganisms contribute to inflammatory diseases are extremely important. In light of this, studies targeting the oral microbiota in health and disease will provide valuable information on the functional and metabolic changes in diverse pathological states, as well as the identification of molecular signatures, which could lead to assertive therapies considering precision medicine (1). Interestingly, oral samples are easy to collect, and, therefore, studies in this regard have been increasing in the past few years.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Interplay Between Oral Diseases, Microbiome, and Chronic Diseases Driven by Metabolic Dysfunction in Childhood

et al. 2021

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Oral childhood diseases, such as caries and gingivitis, have much more than a local impact on the dentition and tooth surrounding tissues, which can affect systemic conditions. While the mouth is frequently exposed to microbial stressors that can contribute to an inflammatory state in the entire body, chronic disorders can also interfere with oral health. Sharing common risk factors, a dynamic interplay can be driven between 1. dental caries, gingivitis, and type I diabetes mellitus, 2. early childhood caries and obesity, and 3. caries and cardiovascular diseases. Considering that there are ~2.2 billion children worldwide and that childhood provides unique opportunities for intervention targeting future health promotion, this review is of prime importance and aimed to explore the relationship between the oral microbiome and oral chronic diseases driven by metabolic dysfunction in childhood.

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Nature of the Interplay Between Periodontal Diseases and COVID-19

et al. 2021

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The coronavirus disease 2019 (COVID-19) is mostly a mild condition, however, in some patients, it could progress into a severe and even fatal disease. Recent studies have shown that COVID-19 infection and severity could be associated with the presence of periodontitis, one of the most prevalent chronic diseases. This association could be explained by the fact that periodontitis and COVID-19 share some common risk factors that included chronic diseases, such as diabetes and hypertension as well as conditions such as age, sex, and genetic variants. Another possible explanation could be the systemic inflammation and the aspiration of periodontopathogens seen in patients with periodontitis, which could have a synergism with the virus or compromise the reaction of the body against COVID-19. This narrative review explores the nature of these associations, the evidence behind them, and their implications.

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Odontogenic keratocyst with granular cell changes: A distinctive finding

Cited by 14 publications

References 20 publications

Microbiome or Infections: Amyloid-Containing Biofilms as a Trigger for Complex Human Diseases

Microbiome or Infections: Amyloid-Containing Biofilms as a Trigger for Complex Human Diseases

Exploring the Interplay Between Oral Diseases, Microbiome, and Chronic Diseases Driven by Metabolic Dysfunction in Childhood

Nature of the Interplay Between Periodontal Diseases and COVID-19

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