Odontogenic Maxillofacial Infections: A Ten-Year Retrospective Analysis

Rasteniene, Ruta; Pūrienė, Alina; Aleksejūnienė, Jolanta; Pečiulienė, Vytautė; Zaleckas, Linas

doi:10.1089/sur.2013.264

Cited by 31 publications

(31 citation statements)

References 21 publications

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“…This study is part of the rare prospective studies about severe odontogenic infection [3,11,12], with over 653 patients included, it was one of the largest. Our population with a mean age of 37 years-old, a male dominance, a poor health status, a maximum of mandibular molar infected with submandibular and perimandibular space involvement is similar to the literature [1,[3][4][5][6][7][8][11][12][13][14][15][16][17]. Penicillin allergic reported is 7% in our study, 4.1% in Zirk et al study and 8% in Flynn et al study [3,17].…”

Section: Discussionsupporting

confidence: 89%

“…If CRP level is between 50 and 200 mg/l and the patient not allergic to penicillin, two criteria must be add to obtain a risk factor of 33%: mandibular molar infection and psychiatric disorders. Mandibular molar is the most frequent tooth involved in severe odontogenic infection [3,5,7,11,13,14] and is responsible of infection spreading preferentially in the submandibular space [13,15,17,25,26]. Moreover, in our study it is also strongly correlate with unfavourable evolution.…”

Section: Discussionsupporting

confidence: 63%

“…Penicillin allergic reported is 7% in our study, 4.1% in Zirk et al study and 8% in Flynn et al study [3,17]. Multiple tooth involvement, multiple space infected, systemic disease, prescription of non-penicillin antibiotic or of antibiotic combination, empirical antibiotic treatment changed after microbiologic assessment are predictors of hospitalization in patients with acute odontogenic infection [15]. Comparing our population to the data reported by the Institut National de prevention et d'Education pour la santé (INPES), showed that it is more vulnerable than general population with a higher proportion of alcohol, nicotine and drug abuse.…”

Section: Discussionmentioning

confidence: 42%

“…2). For patients with CRP level between 50 and 200 mg/l without penicillin allergy nor psychiatric disorders but with infection involving mandibular molar, the risk factor is only 9% (IC95% = [5][6][7][8][9][10][11][12][13][14][15][16][17], n = 107) to need several surgical interventions.…”

Section: Antibiotics and Infection Evolutionmentioning

confidence: 99%

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Five Predictors Affecting the Prognosis of Patients with Severe Odontogenic Infections

Dang

Delbet-Dupas

Mulliez

et al. 2020

Preprint

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Background: For over ten years, dental cellulitis management is not so longer simple: more and more patients need long-time hospitalization, several surgical interventions and intensive care follow-up. This prospective study seeks to highlight criteria that can split patients with severe odontogenic infection into two main groups: those with simple evolution after treatment of the infection and those for whom complex management is necessary to obtain healing.Methods: All patients with severe odontogenic infection (namely patients which necessitated hospital admission, intravenous antibiotherapy and general anesthesia) were prospectively recorded between January 2004 and December 2014. Statistical tests used were: chi-square test (or Fisher’s exact test when appropriate) for categorical data, and Student t-test (or Mann & Withney test when appropriate) for continuous data; statistics were computed with STATA V12 (Stata Corp, College Station, Texas, USA) and with R (R version 3.0.2; The R Foundation for Statistical Computing, Vienna, Austria; http://www.r-project.org).Results: A total of 653 patients were included in the study, 611 (93.6%) had one surgery, 42 (6.4%) had more than one surgery (range 2 – 15 surgeries) before healing. In multivariate analysis, objectives criteria which emerge are: C-reactive protein (CRP) level (CRP>200 mg/l, p=0.01, OR=4.12 IC95%=[1.33-12.72]), alcohol abuse (p=0.03, OR=2.70 IC95%=[1.09-6.7]), penicillin allergy (p=0.001, OR=5.47 IC95%=[1.99-15-09]), mandibular molar infection (p= 0.02, OR=2.74 IC95%=[1.16-6.48]). A conditional inference tree (CTREE) illustrated the association of prognostic factors and the need of multiple surgery. Conclusion: Four subgroups of patients with severe odontogenic infection have a relative risk range between 25 % and 33% to have several surgical intervention associated with complications as intensive unit care follow-up, tracheotomy or death: 1- patients with CRP>200 mg/l; 2- patients with CRP between 50 and 200 mg/l and penicillin allergy; 3- patients with CRP between 50 and 200 mg/l, without penicillin allergy but with molar mandibular infection and psychiatric disorders; 4- patients with CRP ≤ 50 mg/l or unknown CRP level and immunodepression.IRB number: CE-CIC-GREN-12-08

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 42%

Section: Antibiotics and Infection Evolutionmentioning

confidence: 99%

See 2 more Smart Citations

Five Predictors Affecting the Prognosis of Patients with Severe Odontogenic Infections

Dang

Delbet-Dupas

Mulliez

et al. 2020

Preprint

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“…Moreover, in some cases, this lingual positioning of teeth results in apical fenestrations, which represent interruptions of the mandibular lingual cortical plate contour [ 5 , 6 ]. The close proximity of the root apices of posterior teeth to the cortical bone may lead the infection to penetrate into the adjacent facial spaces [ 7 ]. Involvement of submandibular and sublingual spaces causes severe symptoms such as neck rigidity, trismus, dysphagia, respiratory distress, sialorrhea, and pyrexia.…”

Section: Introductionmentioning

confidence: 99%

Risk Factor in Endodontic Treatment: Topographic Evaluation of Mandibular Posterior Teeth and Lingual Cortical Plate Using Cone Beam Computed Tomography (CT)

Aksoy

Orhan

2018

Med Sci Monit

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BackgroundTopographic relationships of mandibular posterior teeth with mandibular cortical plate are extremely important both in terms of infection spread and endodontic and surgical procedures to be performed. The aim of this study was to determine the relationship between root apex of the mandibular posterior teeth and lingual plate of the mandible.Material/MethodsCBCT data of 138 patients were retrospectively analyzed. The topographic relationship between root apex and lingual plate was classified as non-contact, contact, or perforation. Morphology of the mandibular lingual plate was classified into the 4 types (convex, parallel, undercut, slanted) and recorded for each tooth region. The prevalence of each group was calculated.ResultsIn 6.2% of all mandibular posterior teeth, the lingual plate was perforated by at least 1 root of the corresponding tooth. The teeth with the highest perforation rate were the third molar tooth (31.6%) and the second molar tooth (14.7%). The most common mandibular lingual plate morphology type was “undercut type” (61.3%) in the molar teeth region, while “parallel type” (55.7%) was most common in the premolar teeth region.ConclusionsIn conclusion, a high percentage of mandibular second and third molars root apex have topographically close relationships to the lingual plate of the mandible. Hence, endodontic consultants must be aware by this anatomical relationship and be aware of possible complications during endodontic and surgical procedures using radiographical modalities.

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Nanomaterials in Antibacterial Photodynamic Therapy and Antibacterial Sonodynamic Therapy

He,

Feng,

Hao

et al. 2024

Adv Funct Materials

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Antibacterial photodynamic therapy (aPDT) and antibacterial sonodynamic therapy (aSDT) utilize sensitizers (photosensitizers/sonosensitizers) to produce reactive oxygen species (ROS) for antibacterial treatment under the stimulation of light/ultrasound, which have the characteristics of broad‐spectrum antibacterial properties, low drug‐resistance, and effective targeting of infected tissues. Nanomaterials in aPDT/aSDT are primarily used as nano‐sensitizers or nano‐carriers of sensitizers. They enhance the stability and permeability of sensitizers, improve targeting of sensitizers, strengthen photodynamic/sonodynamic properties of sensitizers (modification of sensitizers absorption efficiency and light/ultrasonic response stress by modulation of nanoparticle shape, size, and structure). Also, they improve modifiability of sensitizers (controlling the release rate and time of the sensitizer as needed to optimize the therapeutic effect), enhance programmability and multifunctionality of sensitizers (flexible application of nanotechnology for designing sensitizers with multiple functions, such as drug delivery, targeted therapy, and therapeutic monitoring), and expand possibilities for combination therapies (the nano‐carriers can be loaded with other therapeutic agents, enabling combination therapies). Nanomaterials are expected to further promote the development of aPDT/aSDT and achieve improved antibacterial effects. This review summarizes the progress in nanomaterials in aPDT/aSDT in recent years and based on the current development strategies to provide a theoretical reference for the application of nanomaterials in aPDT/aSDT.

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Odontogenic Maxillofacial Infections: A Ten-Year Retrospective Analysis

Cited by 31 publications

References 21 publications

Five Predictors Affecting the Prognosis of Patients with Severe Odontogenic Infections

Five Predictors Affecting the Prognosis of Patients with Severe Odontogenic Infections

Risk Factor in Endodontic Treatment: Topographic Evaluation of Mandibular Posterior Teeth and Lingual Cortical Plate Using Cone Beam Computed Tomography (CT)

Nanomaterials in Antibacterial Photodynamic Therapy and Antibacterial Sonodynamic Therapy

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