Odontogenic tumors and lesions treated in a single specialist oral and maxillofacial pathology unit in the United Kingdom in 1992–2016

Abstract

Objectives: Odontogenic tumours (ODTs) are a heterogeneous group of lesions derived from elements of the tooth-forming tissues. There are no published detailed data on the incidence of odontogenic tumours in the UK. Aim: to retrospectively describe the range and incidence of odontogenic tumours from 1992-2016 in a single specialist unit and to compare this with other populations. Study Design: Using the Oral and Maxillofacial Pathology database, Sheffield, both local and referred consultation cases were included. A proportion of diagnoses were re-classified in accordance with the 2017 WHO classification. Results: In total, 559 odontogenic tumours were diagnosed. Overall, the most common lesions were ameloblastoma (196; 33.8%), odontome (148; 25.5%) and odontogenic myxoma (37; 6.3%), but this varied between local and referral case populations, with odontomes most common in the local population (43%). The sites affected, gender and age of patients were similar to other western populations. Malignant ODTs comprised 33 cases (5.7%), of which nine (27.3%) were ameloblastic carcinoma. The majority of the malignant ODTs were referral cases. Conclusions: These are the first detailed data on odontogenic tumours within a UK population and the pattern of incidence from the local population is similar to other western populations. The exceptional rarity of malignant ODTs emphasises the need for specialist centres in order to gain diagnostic experience.

CEOT Variants or Entities: Time for a Rethink? A Case Series with Review of the Literature

“…According to this recent review of published cases, there was an almost equal distribution among males and females and the peak age of occurrence of central lesions was in the 3rd and 4th decades, similar to that presented in our recent series of odontogenic tumors [11]. The majority occurred in the body of the mandible, but some were large lesions, extending widely antero-posteriorly and involving the ramus [10,11]. Most presentations are intraosseous but in 1966, Pindborg described an extra-osseous/ peripheral CEOT [12].…”

“…Since the original descriptions, the number of cases has continued to increase and, to date, more than 362 cases have been reported [10]. According to this recent review of published cases, there was an almost equal distribution among males and females and the peak age of occurrence of central lesions was in the 3rd and 4th decades, similar to that presented in our recent series of odontogenic tumors [11]. The majority occurred in the body of the mandible, but some were large lesions, extending widely antero-posteriorly and involving the ramus [10,11].…”

Association between odontoma size, age and gender: Multivariate analysis of retrospective data

“…The World Health Organization (WHO) (1) classifies odontomas as compound (CO), characterized by disorganized dental formations, and complex odontoma (CxO) manifested as a disorganized dental mass (2-5).…”

“…Its prevalence encloses 4 to 78% of all tumors of dental origin (2). At the same time, prevalence of the CxO is from 21 to 74%, and of CO, from 20 to 71%, being greater in one case or the other, depending on the study (3-12), however, some authors report a bigger prevalence of the CO (6).…”

“…Odontoma is observed with greater frequency during the second and third decades of life (8,13), ranging from 3 to 71 years of age (2); additionally, there is no observed tendency over sex. There is also no observable inclination over an anatomic location in the buccal cavity (7); however, some particularities have been documented (3,6,8,12).…”