Odontogenic tumours in Nigeria: A multicentre study of 582 cases and review of the literature

Abstract

BackgroundThe objective of this study was to classify the various types of odontogenic tumours (OTs) using the newly updated 2017 world health organization (WHO) histological typing and to analyze the prevalence of these tumours among Nigerians as well as to compare the results obtained with reports from world-wide studies.Material and MethodsThe records of four major tertiary hospitals in Nigeria were reviewed over a 12-year (2004-2015) period. Lesions diagnosed as odontogenic tumours were classified into four groups according to the 2017 WHO histological typing. Data which consisted of age, sex and site were analyzed using SPSS for Window (version 20.0; SPSS Inc., Chicago, IL) and frequency tables were computed.ResultsA total of 582 OTs were recorded and reviewed, benign OTs were 573 (98.5%) cases and malignant OTs were 9 (1.5%) cases. Of the benign OTs, the epithelial OTs were the commonest (500; 86%) while the benign mixed OTs were the least frequent (21; 3.6%). The mean age was 30±14 years (age range of 3–77years) and the peak age was in the third decade (197; 33.8%) of life. There was slight male gender and strong mandibular site predilection. Ameloblastoma, was the most frequent OT and it accounted for 75.5% of the OTs, followed by adenomatoid odontogenic tumour (8.1%) and odontogenic myxoma (7.2%). Malignant OTs accounted for 1.5% of the OTs.ConclusionsOTs show a geographic variation with tendency for prevalence of the epithelial OTs in Africa. Ameloblastoma has a high prevalence among Nigerians and is the most common OTs in Africa. Prevalence of odontoma is relatively low in developing African countries like Nigeria when compared to the prevalence in developed countries. Key words:Odontogenic tumours, WHO classification, Nigerians.

Odontoma composto em adulto e sua complexidade de tratamento: relato de caso clínico

“…Em populações africanas, entretanto, os ameloblastomas correspondem aos tumores mais frequentes 11,12 . Essa marcante discrepância foi associada ao subdiagnóstico e ao baixo número de casos relatados [11][12][13] .…”

“…Em populações africanas, entretanto, os ameloblastomas correspondem aos tumores mais frequentes 11,12 . Essa marcante discrepância foi associada ao subdiagnóstico e ao baixo número de casos relatados [11][12][13] .O tratamento de escolha para o odontoma é a enucleação cirúrgica, tal como descrito por Gold et al 14 (1991), seguida de envio do espécime ao exame anatomopatológico 14 . O tratamento cirúrgico pode ser agressivo, principalmente em lesões extensas e diagnosticadas tardiamente em mandíbula, elevando o risco de fratura mandibular [15][16][17] .…”

Frecuencia de odontomas en pacientes pediátricos atendidos en un centro dental docente entre los años 2015-2018 Lima - Perú. Estudio retrospectivo

“…5,7,10,14,16,18,19 En el presente estudio se evidencio que esta entidad se encuentra ligeramente más en el sexo femenino 1,38% (n=20). [20][21][22] En cuanto al género, en Italia se realizó un estudio por el ISTAT (Italian National Institute of Statistics) donde encontraron que los niños tienen menos controles a la salud dental que las niñas y se presume que por este motivo probablemente exista una mayor frecuencia en el sexo femenino. 23 Respecto a la edad dental, el presente estudio encontró que la entidad fue más frecuente en la dentición permanente, es decir en la segunda década de vida, similar a múltiples estudios.…”

Expression of Matrix Metalloproteinases in Ameloblastomas and Ameloblastic Carcinoma: Systematic Review and Meta-analysis

“…AB is estimated to account for 11% of all odontogenic tumors on a global scale. [1][2][3][4] The World Health Organization has defined AB as a benign odontogenic tumor formed by odontogenic epithelium with fibrous mature stroma but without odontogenic ectomesenchyme. 5 AB cells usually invade into the cancellous bone beyond the tumor margin.…”