2009
DOI: 10.1073/pnas.0810151106
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Odor coding by modules of coherent mitral/tufted cells in the vertebrate olfactory bulb

Abstract: calcium imaging ͉ mitral cell ͉ synchronous activity T he glomeruli of the olfactory bulb (OB) constitute an important interface for the coding of odor information. Every individual glomerulus collects convergent inputs from olfactory sensory neurons (OSN) expressing the same olfactory receptor (OR) (1), and it delivers output information to higher brain regions via a number of M/T cells connected to it (2). This modular architecture is thought to play a fundamental role in odor coding (3).M/T cells of the sam… Show more

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Cited by 31 publications
(41 citation statements)
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“…Evidence of transient odor-evoked synchrony of neuronal firing has been obtained in the ALs of moths and OBs of rats, particularly for output neurons from individual glomeruli (22,32,46). Interglomerular synchrony of neuronal activity, by contrast, may serve to bind features of a complex stimulus, and synchronized activity of certain units in an ensemble has been correlated with behavior (30,31).…”
Section: Discussionmentioning
confidence: 93%
“…Evidence of transient odor-evoked synchrony of neuronal firing has been obtained in the ALs of moths and OBs of rats, particularly for output neurons from individual glomeruli (22,32,46). Interglomerular synchrony of neuronal activity, by contrast, may serve to bind features of a complex stimulus, and synchronized activity of certain units in an ensemble has been correlated with behavior (30,31).…”
Section: Discussionmentioning
confidence: 93%
“…Analogous circuitry requirements have been suggested in visual cortex to explain the distance dependence of R noise (21). Raw crosscorrelation is elevated in NEAR cells in other olfactory preparations (16,30,31), and noise correlation in sister cells has been measured in nonmammalian olfactory structures (15,16). Alternatively, finite dendritic length in granule cells, which limits the range of connectivity (32), may also introduce spatially dependent correlations.…”
Section: Discussionmentioning
confidence: 99%
“…Cell pairs' spiking may also exhibit covariation beyond that predicted from such preferences ("noise correlation," R noise ) and may reflect correlated input noise or synaptic coupling between cells (13,14). In Xenopus and Drosophila, M/Ts and their analogs exhibit significant noise correlation (15,16). However, the origins, magnitude, and scope of such correlations have not been described in the mammalian OB.…”
mentioning
confidence: 97%
“…The circuitry in both OBs and ALs extracts and optimizes the relevant odorant information. In mammals, the principal neurons in the OB, named mitral/tufted (M/T) cells, display odor-dependent discharge, and deliver odorant information to high brain regions (Chen et al, 2009;Restrepo et al, 2009). To study the odorspecific response of OBs, a 2-deoxyglucose method by optical imaging were used for visualization of OB glomeruli (Meister and Bonhoeffer, 2001;Bathellier et al, 2007), and microelectrodes were implanted in OBs for recording spike trains of M/T cells (Kay and Laurent, 1999;Friedrich and Laurent, 2001;Egana et al, 2005;Rinberg et al, 2006;Davison and Katz, 2007;Cury and Uchida, 2010).…”
Section: Introductionmentioning
confidence: 99%