Odour perception: A review of an intricate signalling pathway

Tromelin, Anne

doi:10.1002/ffj.3295

Cited by 19 publications

(18 citation statements)

References 537 publications

(626 reference statements)

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“…In contrast, no statistical difference was detected for odour identification function across weight groups, despite significant results being observed in a recent empirical study . Inconsistent results between these olfactory assessments are not unexpected, as neuroimaging data suggest that olfactory detection, discrimination, and identification are likely to involve distinct brain regions …”

Section: Resultsmentioning

confidence: 77%

Systematic review of olfactory shifts related to obesity

et al. 2018

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Objective: The modern food environment is a key driver of rising levels of obesity.While olfaction is known to play a major role in food choice; however, its relationship to obesity is yet to be understood. This review assesses current knowledge of the interaction between obesity and olfaction.Methods: This review is based on observational studies comparing olfactory abilities across weight groups (N = 10) and clinical studies evaluating olfactory changes following bariatric surgery (N = 9). Meta-analyses were performed on data collected by a standard olfactory assessment tool (Sniffin΄ Sticks), to test whether olfaction has any association with body weight or bariatric surgery.Results: This review synthesizes findings derived from 38 datasets, with a total of 1432 individual olfactory assessments. The meta-analyses suggest that olfactory function is negatively correlated with body weight. In addition, Roux-en-Y gastric bypass patients frequently report olfactory changes, yet more pronounced and immediate shifts have been observed among sleeve gastrectomy recipients.Conclusions: Our review finds strong evidence for the link between olfaction and obesity and indicates that bariatric surgery (particularly the sleeve gastrectomy) is effective in reversing olfactory decline associated with obesity. In conclusion, we present mechanistic models to underpin the observed relationship between olfaction and obesity.

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Section: Resultsmentioning

confidence: 77%

Systematic review of olfactory shifts related to obesity

et al. 2018

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“…Predator recognition by olfactory cues does not require cortical information processing (Canteras et al, 2015). Discrimination of different odorants is achieved by the narrow sensitivity to chemical cues from each receptor type in the accessory olfactory system (AOS; Mucignat-Caretta, 2010; Ma, 2012;Canteras et al, 2015;Tromelin, 2016). In laboratory rodents, different predator odors activate receptors from distinct olfactory subsystems (Canteras et al, 2015).…”

Section: Smellmentioning

confidence: 99%

Parameters That Affect Fear Responses in Rodents and How to Use Them for Management

et al. 2019

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The strong innate fear response shown by laboratory rodents to predator cues could provide powerful and innovative tools for pest management. Predator cues are routinely used to induce fear and anxiety in laboratory rodents for pharmacological studies. However, research on the fear response induced by predator cues in different species of rodents in the wild has been inconclusive with results often contradictory to laboratory experiments. Potential explanations for this inconsistency include the prey's: (i) physiological state; (ii) parasite load; (iii) differential intensity of perceived threats; (iv) fear learning and habituation; and (v) information gathering. In this review, we first explore current knowledge on the sensory mechanisms and capabilities of rodents, followed by the discussion of each of these explanations within the context of their implications for the use of antipredator response as a pest rodent management tool. Finally, we make recommendations on potential solutions and strategies to resolve issues in rodent management related to these hypotheses.

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“… 19 , 41 , 45 , 47 , 55 , 83 , 86–99 In humans, olfactory and hormonal systems are related to each other. 19 , 45 , 47 , 50 , 58 , 60 , 100 Ectopic ORs have a local action not linked with CNS. At the kidney level, they control blood pressure based on the level of short-chain fatty acids produced by the gut microbiota.…”

Section: Particularities Of Orsmentioning

confidence: 99%

Could the Olfactory System Be a Target for Homeopathic Remedies as Nanomedicines?

Courtens¹,

Demangeat²,

Benabdallah

2018

The Journal of Alternative and Complementary Medicine

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Homeopathic remedies (HRs) contain odorant molecules such as flavonoids or terpenes and can lose their efficiency in presence of some competitive odors. Such similarities, along with extreme sensitivity of the olfactory system, widespread presence of olfactory receptors over all organic tissues (where they have metabolic roles besides perception of odors), and potential direct access to the brain through olfactory nerves (ONs) and trigeminal nerves, may suggest the olfactory system as target for HRs. Recent works highlighted that HRs exist in a dual form, that is, a still molecular form at low dilution and a nanoparticulate form at high dilution, and that remnants of source remedy persist in extremely high dilutions. From the literature, both odorants and nanoparticles (NPs) can enter the body through inhalation, digestive absorption, or through the skin, especially, NPs or viruses can directly reach the brain through axons of nerves. Assuming that HRs are recognized by olfactory receptors, their information could be transmitted to numerous tissues through receptor–ligand interaction, or to the brain by either activating the axon potential of ONs and trigeminal nerves or, in their nanoparticulate form, by translocating through axons of these nerves. Moreover, the nanoparticulate form may activate the immune system at multiple levels, induce systemic various biological responses through the pituitary axis and inflammation factors, or modulate gene expression at the cellular level. As immunity, inflammation, pituitary axis, and olfactory system are closely linked together, their permanent interaction triggered by olfactory receptors may thus ensure homeostasis.

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Odour perception: A review of an intricate signalling pathway

Cited by 19 publications

References 537 publications

Systematic review of olfactory shifts related to obesity

Systematic review of olfactory shifts related to obesity

Parameters That Affect Fear Responses in Rodents and How to Use Them for Management

Could the Olfactory System Be a Target for Homeopathic Remedies as Nanomedicines?

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