Oedema in the Lower Limb of Patients with Chronic Critical Limb Ischaemia (CLI)

Abstract

a significantly reduced plasma albumin concentration cannot be regarded as a causative factor, since the oedema is unilateral. The aetiology of oedema formation is probably multifactorial, and further investigations are under progress to elucidate relevant pathogenetic factors.

Marriage of resistance and conduit arteries breeds critical limb ischemia

“…Edema formation is a paradoxical finding, because CLI, by definition, is a state of hypopressure and hypoperfusion. Nonetheless, in ϳ70% of patients with CLI, edema is confined to the distal portion of the affected leg (44,45). More than 90% of CLI patients undergo angioplasty and/or vascular reconstruction within 1 yr of diagnosis (67).…”

Edema in the Lower Limb of Patients Operated on for Proximal Femoral Fractures

“…Their width was approximately 70% of the circumference of the limb. 27 The pressure in the recording cuff was 6 mm Hg, and a venous occlusion pressure of 50 mm Hg was maintained for 1 minute. That permitted an uninhibited arterial flow into the limb while venous outflow was compromised, thus resulting in increased leg volume.…”

The effect of peripheral vascular disease on structure and function of resistance arteries isolated from human skeletal muscle

“…The alteration in small artery function as a consequence of chronic ischaemia is clearly evident as approximately 70% of patients with PVD present with oedema confined to the distal portion of the affected leg and all display uncontrolled orthostatic-dependent changes in leg blood volume (Khiabani et al, 1999). The alteration in small artery function as a consequence of chronic ischaemia is clearly evident as approximately 70% of patients with PVD present with oedema confined to the distal portion of the affected leg and all display uncontrolled orthostatic-dependent changes in leg blood volume (Khiabani et al, 1999).…”

“…Resistance arteries are the primary determinant of blood flow ⁄ pressure within the delicate capillary beds. The alteration in small artery function as a consequence of chronic ischaemia is clearly evident as approximately 70% of patients with PVD present with oedema confined to the distal portion of the affected leg and all display uncontrolled orthostatic-dependent changes in leg blood volume (Khiabani et al, 1999). In PVD, there is often an inability to regulate blood volume within the diseased part of the leg as in many subjects elevation of the feet results in capillary collapse and ÔpallorÕ of the distal ischaemic part of the limb.…”