OEDL: an optimized ensemble deep learning method for the prediction of acute ischemic stroke prognoses using union features

Abstract

BackgroundEarly stroke prognosis assessments are critical for decision-making regarding therapeutic intervention. We introduced the concepts of data combination, method integration, and algorithm parallelization, aiming to build an integrated deep learning model based on a combination of clinical and radiomics features and analyze its application value in prognosis prediction.MethodsThe research steps in this study include data source and feature extraction, data processing and feature fusion, model building and optimization, model training, and so on. Using data from 441 stroke patients, clinical and radiomics features were extracted, and feature selection was performed. Clinical, radiomics, and combined features were included to construct predictive models. We applied the concept of deep integration to the joint analysis of multiple deep learning methods, used a metaheuristic algorithm to improve the parameter search efficiency, and finally, developed an acute ischemic stroke (AIS) prognosis prediction method, namely, the optimized ensemble of deep learning (OEDL) method.ResultsAmong the clinical features, 17 features passed the correlation check. Among the radiomics features, 19 features were selected. In the comparison of the prediction performance of each method, the OEDL method based on the concept of ensemble optimization had the best classification performance. In the comparison to the predictive performance of each feature, the inclusion of the combined features resulted in better classification performance than that of the clinical and radiomics features. In the comparison to the prediction performance of each balanced method, SMOTEENN, which is based on a hybrid sampling method, achieved the best classification performance than that of the unbalanced, oversampled, and undersampled methods. The OEDL method with combined features and mixed sampling achieved the best classification performance, with 97.89, 95.74, 94.75, 94.03, and 94.35% for Macro-AUC, ACC, Macro-R, Macro-P, and Macro-F1, respectively, and achieved advanced performance in comparison with that of methods in previous studies.ConclusionThe OEDL approach proposed herein could effectively achieve improved stroke prognosis prediction performance, the effect of using combined data modeling was significantly better than that of single clinical or radiomics feature models, and the proposed method had a better intervention guidance value. Our approach is beneficial for optimizing the early clinical intervention process and providing the necessary clinical decision support for personalized treatment.

Current status and quality of radiomics studies for predicting outcome in acute ischemic stroke patients: a systematic review and meta-analysis

“…Notably, 11 of these studies performed a comparation between models using only clinical features and models incorporating radiomics features. While 4 of these studies ( 41 – 43 , 46 ) did not observe a significant difference in predictive performance, the remaining 7 ( 13 , 38 , 39 , 44 , 47 – 49 ) demonstrated that the inclusion of radiomics significantly improved the predictive ability for AIS prognosis. Moreover, among these 7 studies, 3 ( 38 , 39 , 44 ) directly compared the performance of the radiomics model with the clinical model, and all found that the radiomics model was superior.…”

A comprehensive review for artificial intelligence on neuroimaging in rehabilitation of ischemic stroke

“…The OEDL method achieved a Macro-AUC of 97.89% and ACC of 95.74%. The SMOTEENN-based mixed sampling method exhibited the best classification performance, with Macro-AUC, ACC, Macro-R, Macro-P, and Macro-F1 reaching 97.89, 95.74, 94.75, 94.03, and 94.35%, respectively ( 93 ).…”