$OElig;SOPHAGEAL ACID-PERFUSION IN THE DIAGNOSIS OF PRECORDIAL PAIN

Bennett, J. R.

doi:10.1016/s0140-6736(66)90472-7

Cited by 77 publications

(19 citation statements)

References 5 publications

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“…Since then, other workers have similarly found positive acid perfusion test results in 5%-15% of 'normal subjects'. [4][5][6][7]11 These studies were mostly performed in the era before 24-h pH monitoring, and so it was not clear if the 'normal subjects' were truly free of pathological reflux. Among patients with non-cardiac chest pain, acid perfusion tests correlated poorly with pH monitoring.…”

Section: Discussionmentioning

confidence: 99%

Esophageal mucosal acid sensitivity can coexist with normal pH recording in healthy adult volunteers

Kang

2000

Journal of Gastroenterology

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We aimed to determine whether healthy volunteers with normal pH monitoring study results experienced heartburn or discomfort during an esophageal acid perfusion test. We performed an esophageal acid perfusion test, followed by ambulatory esophageal pH monitoring, in 15 healthy and asymptomatic volunteers (aged 19 to 34 years). The results of the acid perfusion test were correlated with those of the pH monitoring. Three subjects (20%) reported chest discomfort during acid perfusion. The pH data in all subjects were within our laboratory reference ranges; the median (range) percent total time at pH < 4 being 1.7 (0.2-4.0)% [laboratory reference, median (range), 3.0 (0.2-4.0)%]. We concluded that direct infusion of acid onto the distal esophagus can produce discomfort akin to that of gastroesophageal reflux disease in asymptomatic adult volunteers, even in the absence of excessive esophageal acid exposure.

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Section: Discussionmentioning

confidence: 99%

Esophageal mucosal acid sensitivity can coexist with normal pH recording in healthy adult volunteers

Kang

2000

Journal of Gastroenterology

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“…Fol lowing a standard oesophageal manometric study (as described above) 0 .1 M hydrochloric acid was infused via the middle channel of the triple lumen catheter at 150 drops/min for 15 min [21 ]. The manometric re sponse was recorded, together with any symptoms experienced by the patient.…”

Section: Oesophageal Manometrymentioning

confidence: 99%

Oesophageal Function in Patients with Angina Pectoris: A Comparison of Patients with Normal Coronary Angiograms and Patients with Coronary Artery Disease

Schofield

Whorwell²,

Brooks³

et al. 1989

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Oesophageal function was assessed in 52 patients with angina pectoris whose coronary angiograms were completely normal and in 21 patients with angina pectoris who had significant coronary artery disease. During a standard oesophageal manometric study, abnormalities were found in 23 (44%) patients with normal coronary angiograms but in only 2 (10%) patients with coronary artery disease (p < 0.01). Twenty-four (46%) patients with normal coronary angiograms were found to have gastro-oesophageal reflux disease during 24-hour oesophageal pH monitoring. Of the 52 patients with normal coronary angiograms, 19 (37%) had gastro-oesophageal reflux disease and abnormal oesophageal motility, 5 (10%) had gastro-oesophageal reflux disease alone, and 7 (13%) had oesophageal motility disorder alone. The use of provocation procedures, including intravenous edrophonium during oesophageal manometry and treadmill exercise testing during pH monitoring, enabled the oesophageal abnormality to be demonstrated simultaneously with chest pain in 25 of these 31 patients. Typical angina pectoris, coincident with abnormal oesophageal motility, was precipitated in a subgroup of patients who had been shown to have oesophageal manometric abnormalities and gastro-oesophageal reflux disease by the infusion of hydrochloric acid into the oesophagus; both the chest pain and manometric abnormality resolved following the oral administration of antacid.

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“…Although not widely appreciated, esophageal acid perfusion can elicit heartburn in a majority of healthy volunteers without a history of heartburn [40,41]. Heartburn evoked in volunteers, however, differs from that elicited in patients with esophagitis.…”

Section: Esophagosalivary Reflexmentioning

confidence: 98%

“…Most patients with reflux esophagitis experience reproduction of their heartburn upon perfusion of the esophagus with acid [39][40][41]. Although not widely appreciated, esophageal acid perfusion can elicit heartburn in a majority of healthy volunteers without a history of heartburn [40,41].…”

Section: Esophagosalivary Reflexmentioning

confidence: 99%

Role of saliva in esophageal function and disease

Helm

1989

Dysphagia

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$OElig;SOPHAGEAL ACID-PERFUSION IN THE DIAGNOSIS OF PRECORDIAL PAIN

Cited by 77 publications

References 5 publications

Esophageal mucosal acid sensitivity can coexist with normal pH recording in healthy adult volunteers

Esophageal mucosal acid sensitivity can coexist with normal pH recording in healthy adult volunteers

Oesophageal Function in Patients with Angina Pectoris: A Comparison of Patients with Normal Coronary Angiograms and Patients with Coronary Artery Disease

Role of saliva in esophageal function and disease

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