Oerskovia Infection Caused by Contaminated Home Parenteral Nutrition Solution

Guss, William; Ament, Marvin E.

doi:10.1001/archinte.1989.00390060161040

Cited by 28 publications

(13 citation statements)

References 8 publications

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“…Case reports of human infections include endocarditis (O. turbata [355]), meningitis (O. xanthineolytica [222]), endophthalmitis (O. xanthineolytica [209]), infection of a prosthetic joint (O. xanthineolytica [196]), catheter-related bacteremia (O. turbata, O. xanthineolytica [248,260,279,428]), bacteremia caused by contaminated total parenteral nutrition solution (Oerskovia sp. [190]), gangrenous cholecystitis after endoscopic retrograde cholangiopancreaticography (O. xanthineolytica [150]), CAPD peritonitis (O. xanthineolytica [366]), pyonephrosis (NMO [95]), and soft tissue infection (O. xanthineolytica [150]).…”

Section: Genus Oerskoviamentioning

confidence: 99%

Clinical microbiology of coryneform bacteria

et al. 1997

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Coryneform bacteria are aerobically growing, asporogenous, non-partially-acid-fast, gram-positive rods of irregular morphology. Within the last few years, there has been a massive increase in the number of publications related to all aspects of their clinical microbiology. Clinical microbiologists are often confronted with making identifications within this heterogeneous group as well as with considerations of the clinical significance of such isolates. This review provides comprehensive information on the identification of coryneform bacteria and outlines recent changes in taxonomy. The following genera are covered: Corynebacterium, Turicella, Arthrobacter, Brevibacterium, Dermabacter. Propionibacterium, Rothia, Exiguobacterium, Oerskovia, Cellulomonas, Sanguibacter, Microbacterium, Aureobacterium, "Corynebacterium aquaticum," Arcanobacterium, and Actinomyces. Case reports claiming disease associations of coryneform bacteria are critically reviewed. Minimal microbiological requirements for publications on disease associations of coryneform bacteria are proposed.

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Section: Genus Oerskoviamentioning

confidence: 99%

Clinical microbiology of coryneform bacteria

et al. 1997

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“…The types of infections were similar for all species described and included bacteremia, peritonitis, endocarditis, and joint, ocular, and soft-tissue infections. CVC-related bacteremia was a feature in five determined cases (4,9,14,16,18).…”

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confidence: 99%

“…A review of the literature reveals a strong correlation with compromised immune status and the presence of a foreign body ( (14,16,24,25), 1 reported as "nonmotile Oerskovia" (3), and 1 reported as "Oerskovia species" (9). The types of infections were similar for all species described and included bacteremia, peritonitis, endocarditis, and joint, ocular, and soft-tissue infections.…”

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confidence: 99%

Clearance of Cellulosimicrobium cellulans Bacteremia in a Child without Central Venous Catheter Removal

Rowlinson¹,

Bruckner²,

Hinnebusch³

et al. 2006

J Clin Microbiol

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Cellulosimicrobium cellulans (formerly known as Oerskovia xanthineolytica) rarely causes human infection. Infections have been reported in immunocompromised hosts or in patients with foreign bodies, such as catheters, where treatment has generally involved removal of the foreign body. We report on a case in which the organism was isolated in multiple blood cultures from a 13-year-old male. After initial therapy failed, treatment with vancomycin and rifampin resulted in infection clearance without removal of the central venous catheter. CASE REPORTA 13-year-old male with a history of midgut volvulus and subsequent short-bowel syndrome, who had received total parenteral nutrition since shortly after birth, presented to the Emergency Department at the University of California-Los Angeles with fever of 39°C, malaise, and bilateral conjunctivitis. The patient had had numerous urinary tract infections and central venous catheter (CVC) line infections in the last few years with organisms such as Micrococcus, coagulase-negative Staphylococcus, Staphylococcus aureus, and Enterococcus species. In the emergency room, blood was drawn from the CVC and from a peripheral vein. Both specimens grew pleomorphic gram-positive rods in aerobic and anaerobic blood culture bottles that were identified as Cellulosimicrobium cellulans. The patient was hospitalized and initially treated with intravenous vancomycin and cefotaxime, which was changed 2 days later to vancomycin and gentamicin. After 3 days in the hospital, the patient became afebrile and was discharged home to continue intravenous vancomycin therapy. Blood cultures (drawn on hospital day 2) became positive for Cellulosimicrobium cellulans after 72 h. Because the patient had been discharged, he was readmitted even though he was afebrile. Due to the difficulty of finding another line of intravenous access for this patient, an attempt to preserve the CVC was made by adding oral rifampin to the treatment regimen. Once rifampin was begun, subsequent blood cultures (drawn 2, 3, and 5 days after readmission, respectively) were negative. The patient was discharged home to complete therapy of 3 weeks on intravenous vancomycin and oral rifampin. A repeat culture obtained 72 h after discontinuation of antibiotics was negative. The patient has not had any recurrent infections with this organism and continues to use the CVC line on a daily basis (1 year posttherapy).

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“…Case reports of infections due to O. xanthineolytica usually occurred in immunocompromised patients and were associated with the presence of a foreign body or a medical device. These infections included cases of peritonitis and patients undergoing peritoneal dialysis, bacteremia, meningitis, soft tissue infection, infection of a prosthetic joint, endophthalmitis, keratitis and cirrhosis [6][7][8][9][10][11][12][13][14][15][16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Fatal pneumonia in a newborn caused by Oerskovia xanthineolytica

Haydushka

Martı́nez-Martı́nez

Маркова

et al. 2015

J Pediatr Infect Dis

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A premature child was born at 34-35 weeks gestation with aspiration of amniotic fluid. Rupture of the amniotic sac occurred 3 day before delivery. Two days later the child died. From the lungs, after 24 hours cultivation on blood agar, a pure culture of small yellow pigmented colonies was isolated. All other organs remained sterile. Gram stain revealed Gram-positive rods. The strain was catalase positive and motile. The phospholipid and fatty acid compositions were studied. Final identification was done using ApiCoryne (BioMerieux) and the strain was proved as Oerskovia xanthineolytica. Disk diffusion and E test were performed for antimicrobial susceptibility testing. The strain was susceptible to vancomycin, imipenem and cotrimoxazole. This report demonstrates the first fatal case with isolation of this microorganism from the lungs of newborn.

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Oerskovia Infection Caused by Contaminated Home Parenteral Nutrition Solution

Cited by 28 publications

References 8 publications

Clinical microbiology of coryneform bacteria

Clinical microbiology of coryneform bacteria

Clearance of Cellulosimicrobium cellulans Bacteremia in a Child without Central Venous Catheter Removal

Fatal pneumonia in a newborn caused by Oerskovia xanthineolytica

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