Oesophageal Stricturing Secondary to Adult Stevens-Johnson Syndrome: Similarities in Presentation and Management to Corrosive Injury

Agrawal, Anuradha; Bramble, M G; Shehade, S.A.; Dean, Jonathan

doi:10.1055/s-2003-38765

Cited by 7 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the chronic phase, there have been several reports of esophageal strictures occurring months-toyears after the acute phase (Figure 4). [75][76][77] These are treated successfully with endoscopic dilation, and supportive targeted care in the acute phase may mitigate chronic complications, or may alert patients and providers of their potential development. Gastrointestinal consultation is warranted if a patient complains of dysphagia in the acute phase of SJS/TEN.…”

Section: Gastrointestinal/hepatic Involvementmentioning

confidence: 99%

Multidisciplinary care in Stevens-Johnson syndrome

Shanbhag

Chodosh

Fathy

et al. 2020

Therapeutic Advances in Chronic Disease

View full text Add to dashboard Cite

Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are potentially fatal mucocutaneous diseases that can involve many organ systems. Manifestations of SJS/TEN outside of the skin, eyes, and oral mucosa are not well defined or well recognized, and, therefore, are often not addressed clinically. As supportive care improves and mortality from SJS/TEN decreases, chronic complications in affected organ systems are becoming more prevalent. Recognition of the manifestations of SJS/TEN in the acute phase is critical to optimal care. In this review, we review the organ systems that may be involved in SJS/TEN, provide an overview of their management, and propose a list of items that should be communicated to the patient and family upon discharge. The organ systems discussed include the pulmonary, gastrointestinal/hepatic, oral, otorhinolaryngologic, gynecologic, genitourinary, and renal systems. In addition, the significant psychosocial, nutritional, and pain consequences and management of SJS/TEN are discussed.

show abstract

Section: Gastrointestinal/hepatic Involvementmentioning

confidence: 99%

Multidisciplinary care in Stevens-Johnson syndrome

Shanbhag

Chodosh

Fathy

et al. 2020

Therapeutic Advances in Chronic Disease

View full text Add to dashboard Cite

show abstract

“…Although involvement of the GI tract is generally rare, oesophageal strictures are the most common chronic GI complication and develop between 2 months and 2 years after the acute episode . Strictures can be treated successfully with endoscopic dilatation.…”

Section: Gastrointestinal and Hepatic Sequelaementioning

confidence: 99%

Long-term complications of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN): the spectrum of chronic problems in patients who survive an episode of SJS/TEN necessitates multidisciplinary follow-up

2017

View full text Add to dashboard Cite

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse reactions to drugs that cause a life-threatening eruption of mucocutaneous blistering and epithelial sloughing. While the acute complications of SJS/TEN are well described, it is increasingly recognized that survivors may develop delayed sequelae, some of which can be associated with significant morbidity. Studies of long-term SJS/TEN outcomes mostly focus on mucocutaneous and ocular complications. However, other internal organs, such as the respiratory tract and gastrointestinal tract, can be affected. Psychological sequelae are also frequent following the trauma of widespread epidermal necrolysis. An appreciation of the 'chronic' phase of SJS/TEN is needed by clinicians caring for individuals who have survived the acute illness. This review aims to provide an update on the breadth and range of sequelae that can affect patients in the months and years following an acute episode of SJS/TEN.

show abstract

“…SJS/TEN contributes to life-long complications in the chronic phase, affecting multiple organ systems, with published reports from India discussing ophthalmic sequelae of SJS/TEN including bilateral corneal blindness (Kompella et al, 2002;Basu et al, 2018;Vazirani et al, 2018), respiratory and gastrointestinal system complications such as bronchiolitis obliterans (Basker et al, 1997;Dogra et al, 2014), esophageal strictures, druginduced liver injury (Agrawal et al, 2003;Misra et al, 2004;Devarbhavi et al, 2016). Owing to the morbidity and mortality secondary to SJS/TEN in the Asian Indian population, measures in reducing the incidence of SJS/TEN could be beneficial in reducing the overall disease burden.…”

Section: Morbidity and Mortality Of Sjs/ten In The Asian Indian Populationmentioning

confidence: 99%

Genetic Markers for Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis in the Asian Indian Population: Implications on Prevention

et al. 2021

View full text Add to dashboard Cite

This review attempts to collate all the studies performed in India or comprising a population originating from India and to find out if there is an association between the HLA (human leucocyte antigen) type of individual and development of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) subsequent to medication use. The authors performed a PubMed search of all articles published in English from 2009 to 2019 for articles that studied HLA type in patients who developed SJS/TEN after intake of a specific drug in the Asian Indian population or in individuals of Asian Indian origin. The selection criteria were satisfied by a total of 11 studies that reported HLA associations with specific drugs, which induced SJS/TEN, mainly anti-epileptic drugs, and cold medicine/non-steroidal anti-inflammatory drugs. These studies involved a small number of patients, and hence, there is limited evidence to conclude if these associations can be extrapolated to a larger population of the same ethnicity. Similar multi-center studies need to be conducted with a larger sample size to confirm these associations. This would have implications in policy making and for understanding the potential of using genetic markers as a screening tool before prescribing a drug to a patient, which might make them susceptible to developing a potentially life-threatening disease such as SJS/TEN. This is possibly the only mode of primary prevention for this potentially fatal severe cutaneous adverse drug reaction.

show abstract

Oesophageal Stricturing Secondary to Adult Stevens-Johnson Syndrome: Similarities in Presentation and Management to Corrosive Injury

Cited by 7 publications

References 11 publications

Multidisciplinary care in Stevens-Johnson syndrome

Multidisciplinary care in Stevens-Johnson syndrome

Long-term complications of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN): the spectrum of chronic problems in patients who survive an episode of SJS/TEN necessitates multidisciplinary follow-up

Genetic Markers for Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis in the Asian Indian Population: Implications on Prevention

Contact Info

Product

Resources

About