Oestrogen and progesterone receptor dissociation and family history of breast cancer

Lehrer, Steven; Levine, Erica; Savoretti, Penny; Cropley, Joan; Thung, SwanN.; Song, Hee Kyung; Mandell, Lynda R.; Shank, Brenda

doi:10.1016/0140-6736(92)90697-2

Cited by 11 publications

(5 citation statements)

References 6 publications

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“…11 Lehrer et al also documented the relationship between lower ER dissociation constants and a family history of breast cancer. 6 Huang et al reported that a family history of breast cancer produced a higher odds ratio for ER(Ϫ)PR(Ϫ) than for ER(ϩ)PR(ϩ) breast cancer, especially among pre-/perimenopausal women. 12 Meanwhile, no association of the ER gene polymorphism at codon 325 between women with a family history of breast cancer and women without such a history before the age of 40 has been found.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Differences in the Progesterone Receptor Contents Between Familial Breast Cancers and Sporadic Breast Cancers Stratified by Patient Age

Fukutomi¹,

Akashi‐Tanaka²

2001

Surgery Today

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In the present study, we investigated the estrogen (ER) and progesterone receptor (PR) contents of familial breast cancers (FBCs) and compared the findings with those of sporadic breast cancers., stratified by the patients' age. To evaluate the hormone receptor contents of Japanese FBCs, we collected a consecutive series of 250 FBCs and 2,533 sporadic breast cancers (SBCs). These patients were divided into the three groups stratified by the patients' age at initial surgery (group I, under 40 years old; group II, 40-60 years old; group III, over 60 years old). The clinicopathological features of FBCs and SBCs, including ERs and PRs, were analyzed for each group. In all age groups, the PR contents of FBCs were significantly lower than those of SBCs, particularly for group III. In FBCs, the PR content was significantly lower in group III than in groups I or II. In addition, there was a nonsignificant trend towards a high frequency of ER-positive, PR-negative tumors in FBC patients aged 60 years and over. These data indicate that the loss of ER function and/or loss of binding capacity of PR to progesterone was associated with some late-onset FBCS.

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Section: Discussionmentioning

confidence: 98%

“…5 Several researchers have reported a possibility that hormone receptor genetic polymorphism or hormone receptor status is linked with FBC development. 6,7 In the present study, we investigated the hormone receptor contents of FBCs and compared them with the findings of sporadic breast cancers (SBCs), with stratification by patient age.…”

mentioning

confidence: 99%

Differences in the Progesterone Receptor Contents Between Familial Breast Cancers and Sporadic Breast Cancers Stratified by Patient Age

Fukutomi¹,

Akashi‐Tanaka²

2001

Surgery Today

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“…From these results, it appears to be that inherited mutations in exons of the ER‐α gene in ovarian cancers were a very unlikely phenomenon contrary to that observed in breast cancers. Numerous reports about a germline mutation of the ER‐α gene, aberrant genomic structure in the ER‐α locus, and variation in ER‐α protein were made on the hereditary breast cancer cases and high‐risk families, indicating that the ER‐α gene locus might be related to susceptibility of familial breast cancer cases that lack mutations in either BRCA1 or BRCA2 15,28–30 …”

Section: Discussionmentioning

confidence: 99%

Mutational analysis of the estrogen receptor‐α gene in familial ovarian cancer

Wu¹,

Sekiguchi²,

Kashima³

et al. 2005

J of Obstet and Gynaecol

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“…Several researchers have indicated that hormone receptor genetic polymorphism or hormone receptor status could be linked with FBC development. 6-9…”

Section: Introductionmentioning

confidence: 99%

Familial and Sporadic Breast Cancers

et al. 2010

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In the present study, the authors investigated the clinical, histopathological, and immunohistochemical features in familial breast cancer (FBC) patients and compared them with findings in sporadic breast cancers (SBCs); hormone receptor status was stratified by age. A total of 849 patients treated for breast cancer were included in the study. The patients were stratified into 2 groups: FBC, 160 patients (19%), and SBC, 689 patients (81%). FBC tumors differed from SBC tumors by earlier age of diagnosis and low content of progesterone receptor (PR). These characteristics should be of value in evaluating the possibility of mutation and in targeting mutation screening in such families. PR gene polymorphism leads to an increased risk of breast cancer because it determines inadequate control of estrogen receptor (ER)-driven proliferative function. ER+/PR- tumors more frequently showed HER2 (human epidermal growth factor receptor) overexpression and represent a distinct subset in FBC patients. The authors suggest that late-onset FBCs need more intensive therapy and a more careful follow-up.

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Oestrogen and progesterone receptor dissociation and family history of breast cancer

Cited by 11 publications

References 6 publications

Differences in the Progesterone Receptor Contents Between Familial Breast Cancers and Sporadic Breast Cancers Stratified by Patient Age

Differences in the Progesterone Receptor Contents Between Familial Breast Cancers and Sporadic Breast Cancers Stratified by Patient Age

Mutational analysis of the estrogen receptor‐α gene in familial ovarian cancer

Familial and Sporadic Breast Cancers

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