Oestrogen and progesterone receptor status of individual foci in multifocal invasive ductal breast cancer

Garimella, Veerabhadram; Long, Ervine; O’Kane, Sara L.; Drew, Philip; Cawkwell, Lynn

doi:10.1080/02841860600897884

Cited by 26 publications

(28 citation statements)

References 11 publications

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“…In a previous study that evaluated the ER and PR status of individual foci in multifocal breast cancer, the ER status was the same for each focus in all 18 cases [9]. In another study, ER, PR, and HER-2 status was the same in the separate tumors of 32 multicentric breast cancers; and the authors suggested that the results supported the practice of evaluating prognostic markers in only one lesion per cancer [10].…”

Section: Introductionmentioning

confidence: 88%

The hormone receptor, human epidermal growth factor receptor 2, and molecular subtype status of individual tumor foci in multifocal/multicentric invasive ductal carcinoma of breast

Choi¹,

Kim²,

Seol³

et al. 2012

Human Pathology

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Section: Introductionmentioning

confidence: 88%

The hormone receptor, human epidermal growth factor receptor 2, and molecular subtype status of individual tumor foci in multifocal/multicentric invasive ductal carcinoma of breast

Choi¹,

Kim²,

Seol³

et al. 2012

Human Pathology

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“…There are also high concordance rates between core biopsies taken from different parts of the same tumour (ER 100%, PR 85%), 11 as well as between core biopsies taken from the different foci of a multifocal disease. 12 Situations where repeated ER/PR testing should be conducted on subsequent excision are listed in Table 1.…”

Section: Receptor Status Changementioning

confidence: 99%

ER, PR and HER2 testing in breast cancer

Han

2014

Diagnostic Histopathology

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“…These differences were not observed with Progesterone Receptor (PR). In this regard, Garimella et al [23] using immunohistochemical assays, described small differences in ER expression between different tumor foci, which do not affect the positive/negative final result, while PR showed higher variability.…”

Section: Discussionmentioning

confidence: 99%

Infiltrating Breast Carninomas Multifocality: Clinical and Biological Features

Ruibal¹,

Herranz²,

Cortes³

et al. 2012

TOBCANJ

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Abstract:In order to know the associations between multifocality (MF), without related multicentricity (MC), and common clinical and biological parameters, and posterior influence in breast carcinoma behavior, we have developed this study. 816 successive women affected from invasive breast carcinomas, of which 96 were multifocal and 720 nonmultifocal were included in the study. We considered age, size, lymph node involvement, distant metastasis, histological grade, ploidy, cellular synthesis phase, as well as expression of estrogen receptor (ER), progesterone receptor (PgR), androgen receptor (AR), p53, bcl2 and Ki67 by immunohistochemical assays.Taken as a whole, multifocal invasive carcinomas (11%) showed exclusively more distant metastasis and more tumorrelated-deaths. However, when tumors were classified according to histological type, in ductal carcinomas MF courses exclusively with greater lymph node involvement, while in non ductal carcinomas MF showed higher percentage of distant metastasis, higher proliferation and higher number of recurrences. Also, there were NO differences between axillary lymph node involvement and tumor size in multifocal tumors regardless of histology.Our results suggest: 1) MF was found in 11% of invasive breast carcinomas and was associated with higher distant metastasis and number of tumor-related-deaths. 2) in invasive ductal carcinomas, MF was associated, exclusively, with increased axillary node involvement, whereas in other histological types, with a predominance of lobular, it did with higher distant metastasis, cell proliferation and recurrence number, suggesting, in this subtype of tumors where there is higher prognostic/diagnostic value has the MF presence.

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Oestrogen and progesterone receptor status of individual foci in multifocal invasive ductal breast cancer

Cited by 26 publications

References 11 publications

The hormone receptor, human epidermal growth factor receptor 2, and molecular subtype status of individual tumor foci in multifocal/multicentric invasive ductal carcinoma of breast

The hormone receptor, human epidermal growth factor receptor 2, and molecular subtype status of individual tumor foci in multifocal/multicentric invasive ductal carcinoma of breast

ER, PR and HER2 testing in breast cancer

Infiltrating Breast Carninomas Multifocality: Clinical and Biological Features

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