Oestrogen Promotes Coronary Angiogenesis even under Normoxic Conditions

Nematbakhsh, Mehdi; Ghadesi, Mehrzad; Hosseinbalam, Marzieh; Khazaei, Majid; Gharagozlo, Marjan; Dashti, Gholamreza; Rajabi, Parvin; Rafieian, Shahram

doi:10.1111/j.1742-7843.2008.00286.x

Cited by 9 publications

(7 citation statements)

References 45 publications

(59 reference statements)

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“…Estrogen has protective role on cardiovascular system,[21222324252627] however, its protective role in CP-induced nephrotoxicity is not well-established. The main objective of this study was to determine the role of estrogen in CP-induced nephrotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Evidence against protective role of sex hormone estrogen in cisplatin-induced nephrotoxicity in ovarectomized rat model

Pezeshki¹,

Nematbakhsh²,

Nasri³

et al. 2013

Toxicol Int

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Background:Cisplatin (CP) is an effective drug in cancer therapy to treat the solid tumors, but it is accompanied with nephrotoxicity. The protective effect of estrogen in cardiovascular diseases is well-documented; but its nephron-protective effect against CP-induced nephrotoxicity is not completely understood.Materials and Methods:Thirty ovarectomized Wistar rats were divided in to five groups. Groups 1-3 received different doses of estradiol valerate (0.5, 2.5 and 10 mg/kg/week) in sesame oil for 4 weeks, and at the end of week 3, a single dose of CP (7 mg/kg, intraperitoneal [IP]) was administrated. Group 4 (positive control) received the same regimen as group 1-3 without estradiol without vehicle. The negative control group (Group 5) received sesame oil during the study. The animals were sacrificed 1 week after CP injection for histopathological studies.Results:The serum level of blood urea nitrogen and creatinine, kidney tissue damage score (KTDS), kidney weight and percentage of body weight change in CP-treated groups significantly increased (P < 0.05), however, there were no significant differences detected between the estrogen-treated groups (Groups 1-3) and the positive control group (Group 4). Although, estradiol administration enhanced the serum level of nitrite, it was not affected by CP. Finally, significant correlation between KTDS and kidney weight was detected (r2 = 0.63, P < 0.01).Conclusion:Estrogen is not nephron-protective against CP-induced nephrotoxicity. Moreover, it seems that the mechanism may be related to estrogen-induced oxidative stress in the kidney, which may promote the nephrotoxicity.

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Section: Discussionmentioning

confidence: 99%

Evidence against protective role of sex hormone estrogen in cisplatin-induced nephrotoxicity in ovarectomized rat model

Pezeshki¹,

Nematbakhsh²,

Nasri³

et al. 2013

Toxicol Int

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“…We have shown that EVs can prevent and reverse experimental pulmonary hypertension and that there is a miRNA signature of exosomes in human PAH that promotes vascular proliferation (12,13). E2 increases circulation of hematopoietic progenitors leading to microvessel growth in the heart and lungs (14)(15)(16)(17). The pro-inflammatory E2 metabolite 16-hydroxyestrone (16-OHE 1 ) as compared to the 2compounds (2-methoxyestrone [2-ME] and 2-methoxyestradiol) has been linked to cancer angioinvasion and PAH (18)(19)(20).…”

Section: Abstract Word Count: 250mentioning

confidence: 99%

Insights from the Menstrual Cycle in Pulmonary Arterial Hypertension

et al. 2021

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declared that no conflict of interest exists. M.W. has served as a consultant for United Therapeutics and Ximedica. C.E.V. has served as a past consultant for Acceleron Pharma, as a site PI for a clinical trial funded by Eiger Biopharmaceuticals. She has received a research grant to her institution from the CHEST Foundation Research Grant in Pulmonary Arterial Hypertension (supported by Actelion) and a research grant to her institution from United Therapeutics.

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“…The protective role of estrogen in cardiovascular system in women before menopause is well documented [42–47]. The incidence of chronic renal diseases is also gender related and is potentially higher in males [48, 49], which may relate to estrogen-mediated vascular endothelial growth factor [48].…”

Section: Introductionmentioning

confidence: 99%

Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model

Nematbakhsh

Pezeshki

Eshraghi-Jazi

et al. 2012

International Journal of Nephrology

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Background. The nephroprotective effect of vitamins E and C or losartan against cisplatin (CP)- induced nephrotoxicity when they are accompanied by estrogen was investigated. Methods. The ovariectomized rats received estradiol valerate for two weeks. At the end of the first week, a single dose of CP (7 mg/kg, IP) was also administered, and they received placebo (group 1), vitamin E (group 2), vitamin C (group 3), or losartan (group 4) every day during the second week, and they were compared with another three control groups. Results. CP alone increased the serum levels of blood urea nitrogen (BUN), creatinine (Cr), and kidney tissue damage score (KTDS), significantly (P < 0.05), however at the presence of estradiol and CP, vitamin C, vitamin E, or losartan not only did not decrease these parameters, but also increased them significantly (P < 0.05). The serum level of superoxidase dismutase (SOD) was reduced by CP (P < 0.05), but it was increased when estradiol or estradiol plus vitamin C or losartan were added (P < 0.05). Conclusion. The particular pharmacological dose of estrogen used in this study abolish the nephroprotective effects vitamins C and E or losartan against CP-induced nephrotoxicity.

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Oestrogen Promotes Coronary Angiogenesis even under Normoxic Conditions

Cited by 9 publications

References 45 publications

Evidence against protective role of sex hormone estrogen in cisplatin-induced nephrotoxicity in ovarectomized rat model

Evidence against protective role of sex hormone estrogen in cisplatin-induced nephrotoxicity in ovarectomized rat model

Insights from the Menstrual Cycle in Pulmonary Arterial Hypertension

Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model

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