Oestrogen receptor <i>β</i> is expressed in adult human skeletal muscle both at the mRNA and protein level

Wiik, Anna; Glenmark, Birgitta; Ekman, Martin; Esbjörnsson-Liljedahl, Mona; Johansson, Ӧlle; Bodin, Karl; Enmark, Eva; Jansson, Eva

doi:10.1046/j.0001-6772.2003.01186.x

Cited by 108 publications

(103 citation statements)

References 43 publications

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“…7 Estrogens also act through cell membrane located receptors, which can be independent of ESRs. 8 ESRs have been found in human skeletal muscle 9,10 suggesting the contribution of estrogens to muscle functions. Recent experimental animal studies have provided evidence that estrogen, via its receptors, has a role in glucose metabolism in muscle 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Muscular Transcriptome in Postmenopausal Women With or Without Hormone Replacement

Pöllänen

Ronkainen

Suominen

et al. 2007

Rejuvenation Research

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The loss of muscle mass and strength with aging is well characterized, but our knowledge of the molecular mechanisms underlying the development of sarcopenia remains incomplete. Although menopause is often accompanied with first signs of age-associated changes in muscle structure and function, the effects of hormone replacement therapy (HRT) or menopause-related decline in estrogen production in the muscles of postmenopausal women is not well understood.Furthermore the knowledge of the global transcriptional changes that take place in skeletal muscle in relation to estrogen status has thus far been completely lacking. We used a randomized double-blinded study design together with an explorative microarray experiment to characterize possible effects of continuous, combined HRT and estrogen deprivation on the skeletal muscle of fifteen women. Here, we report the differential response of both GO-annotated biological processes and some individual genes responding differentially to the use or non-use of HRT. Our results revealed transcription level changes in, e.g., muscle protein and energy metabolism. In particular, the ubiquitine-proteosome system was found to be effected at several levels. HRT seemed to partially counteract the postmenopause-related transcriptional changes. Our results suggest that during the early postmenopausal years, when there is no counteracting medication available, muscle transcriptome changes notably, whereas HRT appears to slow-down this phenomenon and could therefore aid in maintaining proper muscle mass and function after menopause.3

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Section: Introductionmentioning

confidence: 99%

Muscular Transcriptome in Postmenopausal Women With or Without Hormone Replacement

Pöllänen

Ronkainen

Suominen

et al. 2007

Rejuvenation Research

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“…The two ERs show overlapping, yet distinct, patterns of expression (DahlmanWright et al 2006). Of particular relevance for glucose homeostasis, ERa is the major ER expressed in the liver (Kuiper et al 1997), adipose tissue (Lundholm et al 2004), skeletal muscle (Wiik et al 2003), and pancreatic islets (Geisler et al 2002). ER subtype-specific ligands have been developed, and are increasingly used to further clarify the specific roles of ERa and ERb .…”

Section: Introductionmentioning

confidence: 99%

The estrogen receptor α-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms

Lundholm

Bryzgalova

Gao

et al. 2008

Journal of Endocrinology

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The aim of this study was to validate the role of estrogen receptor a (ERa) signaling in the regulation of glucose metabolism, and to compare the molecular events upon treatment with the ERa-selective agonist propyl pyrazole triol (PPT) or 17b-estradiol (E 2 ) in ob/ob mice. Female ob/ob mice were treated with PPT, E 2 or vehicle for 7 or 30 days. Intraperitoneal glucose and insulin tolerance tests were performed, and insulin secretion was determined from isolated islets. Glucose uptake was assayed in isolated skeletal muscle and adipocytes. Gene expression profiling in the liver was performed using Affymetrix microarrays, and the expression of selected genes was studied by real-time PCR analysis. PPTand E 2 treatment improved glucose tolerance and insulin sensitivity. Fasting blood glucose levels decreased after 30 days of PPT and E 2 treatment. However, PPT and E 2 had no effect on insulin secretion from isolated islets. Basal and insulin-stimulated glucose uptake in skeletal muscle and adipose tissue were similar in PPT and vehicle-treated ob/ob mice. Hepatic lipid content was decreased after E 2 treatment. In the liver, treatment with E 2 and PPT increased and decreased the respective expression levels of the transcription factor signal transducer and activator of transcription 3, and of glucose-6-phosphatase. In summary, our data demonstrate that PPTexerts anti-diabetic effects, and these effects are mediated via ERa.

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“…In support of this, tendon collagen synthesis is lower in women compared with men at rest and after exercise (47). In addition, a lower peak stress in female collagen fascicles from patella tendons has been demonstrated compared with fascicles from men (41).Estrogen receptors have been localized to bone, ligaments, and muscle tissue (39,56,64), and animal data have shown that tendons express transcripts for estrogen receptors (22). However, the effect of estrogen on collagen synthesis is conflicting, which probably is related to variation between animal species and the applied methods.…”

mentioning

confidence: 99%

“…Estrogen receptors have been localized to bone, ligaments, and muscle tissue (39,56,64), and animal data have shown that tendons express transcripts for estrogen receptors (22). However, the effect of estrogen on collagen synthesis is conflicting, which probably is related to variation between animal species and the applied methods.…”

mentioning

confidence: 99%

Effect of administration of oral contraceptives in vivo on collagen synthesis in tendon and muscle connective tissue in young women

Hansen

Miller²,

Holm³

et al. 2009

Journal of Applied Physiology

106

104

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M, Langberg H. Effect of administration of oral contraceptives in vivo on collagen synthesis in tendon and muscle connective tissue in young women. J Appl Physiol 106: 1435-1443, 2009. First published October 9, 2008 doi:10.1152/japplphysiol.90933.2008Women are at greater risk than men for certain kinds of diseases and injuries, which may at least partly be caused by sex hormonal differences. We aimed to test the influence of estradiol in vivo on collagen synthesis in tendon, bone, and muscle. Two groups of young, healthy women similar in age, body composition, and exercisetraining status were included. The two groups were either habitual users of oral contraceptives exposed to a high concentration of synthetic estradiol and progestogens (OC, n ϭ 11), or non-OC-users tested in the follicular phase of the menstrual cycle characterized by low concentrations of estradiol and progesterone (control, n ϭ 12). Subjects performed 1 h of one-legged kicking exercise. The next day collagen fractional synthesis rates (FSR) in tendon and muscle connective tissue were measured after a flooding dose of [ 13 C]proline followed by biopsies from the patellar tendon and vastus lateralis in both legs. Simultaneously, microdialysis catheters were inserted in vastus lateralis and in front of the patellar tendon for measurement of insulin-like growth factor I (IGF-I) and its binding proteins. Serum NH 2-terminal propeptide of type I collagen (PINP) and urine COOHterminal telopeptides of type-I collagen (CTX-I) were measured as markers for bone synthesis and breakdown, respectively. Tendon FSR and PINP were lower in OC compared with control. An increase in muscle collagen FSR postexercise was only observed in control (P Ͻ 0.05). Furthermore, the results indicate a lower bioavailability of IGF-I in OC. In conclusion, synthetic female sex hormones administered as OC had an inhibiting effect on collagen synthesis in tendon, bone, and muscle connective tissue, which may be related to a lower bioavailability of IGF-I. estrogen; exercise; insulin-like growth factor I; ethinyl estradiol; bone COLLAGEN is the most abundant protein in the human body and comprises a very high fraction of the tissue organic mass in bone (90%), tendon (60 -85%), ligament (70%), and intramuscular connective tissue (ϳ30% and up to 90%) (31, 57). The frequency of several diseases linked to collagen-rich tissue seems to be biased by sex (30,34,36,65). Furthermore, women are at a greater risk than men for sustaining certain kinds of soft tissue sports injuries (7, 24, 26). Several epidemiological studies have shown that women have up to six times greater risk of anterior cruciate ligament (ACL) ruptures than activity-matched men (24). It has been suggested that sex hormones may influence collagen turnover, tissue composition, and biomechanical properties of the tissues, which in part may explain sex-specific differences in risk (24). In support of this, tendon collagen synthesis is lower in women compared with men at rest and after exercise (47). In addition, a lower p...

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Oestrogen receptor β is expressed in adult human skeletal muscle both at the mRNA and protein level

Abstract: The present study shows for the first time ERbeta mRNA and protein expression in human skeletal muscle tissue in both males and females.

Cited by 108 publications

References 43 publications

Muscular Transcriptome in Postmenopausal Women With or Without Hormone Replacement

Muscular Transcriptome in Postmenopausal Women With or Without Hormone Replacement

The estrogen receptor α-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms

Effect of administration of oral contraceptives in vivo on collagen synthesis in tendon and muscle connective tissue in young women

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