Oestrogen withdrawal associated psychoses

Mahé, Vincent; Dumaine, Anne

doi:10.1111/j.1600-0447.2001.00288.x

Cited by 33 publications

(12 citation statements)

References 79 publications

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“…The postpartum period is the time of highest vulnerability for risk, with relapse rates exceeding 50% in mixed cohorts . Several factors have been proposed to explain the increased susceptibility to affective episodes associated with pregnancy/postpartum including, but not limited to, medication non‐adherence, alterations in drug pharmacokinetics, changes in reproductive hormonal concentrations, and adverse effects on sleep hygiene/architecture .…”

Section: Resultsmentioning

confidence: 99%

Sex differences in rates of obesity in bipolar disorder: postulated mechanisms

et al. 2013

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A confluence of factors broadly categorized as broad- and sex-based subserve the increased rate of obesity in women with BD. It remains a testable hypothesis that the increased abdominal obesity in women with BD mediates the increased SMR from CVD. A clinical recommendation that emerges from this review is amplified attention to the appearance, or history, of factors that conspire to increase obesity in female patients with BD.

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Section: Resultsmentioning

confidence: 99%

Sex differences in rates of obesity in bipolar disorder: postulated mechanisms

et al. 2013

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“…We were also unable to examine the associations of postpartum psychiatric illness and other reproductive events, such as endocrine function or postpartum hormonal contraceptive use. 13 Other unmeasured and possibly important variables that would have strengthened our study include sleep quality, 9,10 and partner and/or general social support. 1,11,21 Our findings of few associations between routinely documented variables and postpartum psychosis do not precludein fact, they may encouragethe future examination of the social and environmental factors that may exacerbate postpartum psychological risks in vulnerable women.…”

Section: Discussionmentioning

confidence: 99%

“…6 It has been positively associated with primiparity, 2,7 older maternal age, 8 sleep loss, 9,10 low social support, 8,11 the use of prescribed drugs, 12 and estrogen withdrawal. 13 It is most strongly and consistently associated with a pre-conception history and family history of psychosis. [1][2][3]6,[14][15][16][17][18] Harlow et al 14 reported that pre-conception psychotic or bipolar illness significantly increased the likelihood of postpartum hospitalisation for psychotic disorder, with increased likelihood among women with more recent, more frequent, and lengthier pre-conception psychiatric hospitalisations.…”

Section: Introductionmentioning

confidence: 99%

Are prenatal, obstetric, and infant complications associated with postpartum psychosis among women with pre‐conception psychiatric hospitalisations?

Hellerstedt

Phelan

Cnattingius

et al. 2012

BJOG

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Objective To examine the associations of maternal and infant complications with postpartum hospitalisation for psychosis in women with a pre-conception history of psychiatric hospitalisation. Design Population-based study. Setting Swedish medical birth register. Population Primiparous women who gave birth between 1 January 1987 and 31 December 2001, and who had a pre-conception history of psychiatric hospitalisation but who were not hospitalised during pregnancy (n = 1842). Methods International Classification of Diseases (ICD) codes were used to identify prenatal, obstetric, postpartum maternal complications, and newborn health conditions. We used multivariable logistic regression to describe the associations between maternal and infant health conditions and the odds for postpartum hospitalisation for psychosis. Main outcome measure Psychiatric hospitalisation within 90 days of delivery. Results Compared with women who did not have a postpartum psychiatric hospitalisation, hospitalised women were at 2.3 times higher odds (95% CI 1.0–4.9) of having non-psychiatric puerperium complications (e.g. infection, lactation problems or venous complications). No other maternal complications were associated with postpartum psychiatric hospitalisation. Although their infants were at no higher odds for health complications, the offspring of women who had a postpartum psychiatric hospitalisation were at 4.1 times higher odds (95% CI 1.3–12.6) of death within the first 365 days of life than those of women who were not hospitalised. Conclusions We found no prenatal indicators of postpartum risk for psychiatric hospitalisation among high-risk women, but they had higher odds of postpartum pregnancy-related medical problems and, rarely, offspring death.

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“…It has been suggested that the abrupt hormonal withdrawal after delivery may trigger relapse in vulnerable women. 1 The value of estrogen in prevention and treatment of post-partum affective disorder is suggested by some articles. 2,3 We here report a beneficial effect of hormone replacement therapy (HRT) in treatment-resistant post-partum mania.…”

mentioning

confidence: 99%