Oestrogens, Xenoestrogens and Hormone-Dependent Cancers

Ptak, Anna; Gregoraszczuk, Ewa Ł.

doi:10.5772/54464

Cited by 2 publications

(6 citation statements)

References 51 publications

(66 reference statements)

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“…Other studies showed that genistein (5-30 M) dose dependently induced SHBG production up to 7fold by human hepatocarcinoma (Hep-G2) cells in culture 23 . These findings suggested that phytoestrogens may stimulate the synthesis and release of SHBG, thus reducing the proportion of free estradiol circulating in plasma and indirectly lowering breast cancer risk 22 .…”

Section: Influence Of Phytoestrogens On Sex Hormone Binding Globulin (Figure 1)mentioning

confidence: 94%

“…A variety of hormones and drugs, as well as metabolic and nutritional factors, can influence the expression of human SHBG and plasma SHBG levels 19,22 . It has been shown that phytoestrogens can modulate the levels of human sex hormonebinding globulin (hSHBG) in vitro 23 .…”

Section: Influence Of Phytoestrogens On Sex Hormone Binding Globulin (Figure 1)mentioning

confidence: 99%

“…It is only at this point that the biological effect is elicited. If the ligand is bound to SHBG before the protein binds to the membrane, it is blocked from interacting with membranes 22 . In breast cancer, SHBG binds to SHBG-R and activates adenylyl cyclase, leading to the generation of the second messenger, cAMP and its target PKA 29,30 .…”

Section: Influence Of Phytoestrogens On Sex Hormone Binding Globulin (Figure 1)mentioning

confidence: 99%

“…In breast cancer, SHBG binds to SHBG-R and activates adenylyl cyclase, leading to the generation of the second messenger, cAMP and its target PKA 29,30 . The increased PKA levels may inhibit the MAP kinase pathway and then estradiol-induced cell proliferation 22,31 . It has also been reported that inhibition of ERK causes inhibition of the anti-apoptotic effects caused by estradiol 30,32 .…”

Section: Influence Of Phytoestrogens On Sex Hormone Binding Globulin (Figure 1)mentioning

confidence: 99%

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Relationship Between Dietary Phytoestrogens and Endogenous Estrogen: A Review

Radallah¹,

Hind²,

Amsaguine³

et al. 2019

Int. J. Res. Ayurveda Pharm.

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Phytoestrogens are a group of plant-derived compounds that have selective estrogen receptor-mediated agonist or antagonist effects and show potential benefits for human health. This review discusses the interactions between phytoestrogens intake and endogenous estrogen. Phytoestrogens act the same way as estrogen and may also exert biological activity by other mechanisms to modulate endocrine system function. These phytochemicals may interact with estrogen receptors and induce various estrogenic or antiestrogenic effects. Phytoestrogens stimulate also the synthesis and the release of sex hormone-binding globulin, thus decrease free estradiol levels in circulation associated with reduced risk form any disease, such as breast cancer. Furthermore, there is growing evidence that phytoestrogens may directly modulate concentrations of circulating estradiol via interactions with enzymes involved in the estrogen biosynthesis and metabolism such as 17β-hydroxysteroid dehydrogenase, aromatase and steroid sulfatase and through regulation of hypothalamic-pituitary-ovarian axis.

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Section: Influence Of Phytoestrogens On Sex Hormone Binding Globulin (Figure 1)mentioning

confidence: 94%

Section: Influence Of Phytoestrogens On Sex Hormone Binding Globulin (Figure 1)mentioning

confidence: 99%

Section: Influence Of Phytoestrogens On Sex Hormone Binding Globulin (Figure 1)mentioning

confidence: 99%

Section: Influence Of Phytoestrogens On Sex Hormone Binding Globulin (Figure 1)mentioning

confidence: 99%

See 2 more Smart Citations

Relationship Between Dietary Phytoestrogens and Endogenous Estrogen: A Review

Radallah¹,

Hind²,

Amsaguine³

et al. 2019

Int. J. Res. Ayurveda Pharm.

View full text Add to dashboard Cite

show abstract

“…Furthermore, the catechols 2-OH-E2 and 4-OH-E2, with help of peroxidases, form semiquinones, and these can be further oxidized to quinones. The catechol-O-methyltransferase (COMT) defends organisms against genotoxic metabolites by methylation of catechol estrogens …”

Section: Presence Of Methylene Dioxyphenyl Functional Group In Chemic...mentioning

confidence: 99%

Chemicals and Drugs Forming Reactive Quinone and Quinone Imine Metabolites

Klopčič

Dolenc

2018

Chem. Res. Toxicol.

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Quinones and quinone imines are highly reactive metabolites (RMs) able to induce dangerous effects in vivo. They are responsible for all kinds of toxicity, for example, cytotoxicity, immunotoxicity, and carcinogenesis. Furthermore, hepatotoxicity of chemicals/drugs in particular can be induced by quinone and quinone imine metabolites. According to their reactivity, quinones and quinone imines react as Michael’s acceptors with cell proteins or DNA and, in this way, cause damage to the cells. Quinones and quinone imines also have high redox potential and, due to their semiquinone radicals, are capable of redox cycling and forming reactive oxygen species (ROS). However, the presence of quinones and quinone imines structures in compounds is not always responsible for a toxic effect. The main question, therefore, is what are the main factors responsible for the toxicity of the chemicals and drugs that form RMs. For this reason, the presence of structural alerts and evidence for the formation of reactive quinones and quinone imines metabolites and their mechanisms of toxicity through cellular effects are discussed in this review, together with examples.

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Oestrogens, Xenoestrogens and Hormone-Dependent Cancers

Cited by 2 publications

References 51 publications

Relationship Between Dietary Phytoestrogens and Endogenous Estrogen: A Review

Relationship Between Dietary Phytoestrogens and Endogenous Estrogen: A Review

Chemicals and Drugs Forming Reactive Quinone and Quinone Imine Metabolites

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