Of crows and tools

Klump, Barbara Christina

doi:10.1126/science.aaz7775

Science

2019

DOI: 10.1126/science.aaz7775

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Of crows and tools

Barbara Christina Klump

Abstract: Barbara Klump received her master's degree from Heidelberg University, Germany, and a Ph.D. from the University of St Andrews, UK. After completing a postdoctoral fellowship at the University of St Andrews, she moved to the Max Planck Institute of Animal Behavior in Radolfzell , Germany, where she is currently a postdoc in the Cognitive and Cultural Ecology Lab. Her research explores how a species's ecology shapes its behavioral repertoire.

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A multi-omics analysis of glioma chemoresistance using a hybrid microphysiological model of glioblastoma

Shojaei

Amereh²,

Alizadeh

et al. 2022

Preprint

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Chemoresistance is a major clinical challenge in the management of glioblastoma (GBM) Temozolomide (TMZ) is the chemotherapeutic drug of choice for GBM; however, the therapeutic effect of TMZ is limited due to the development of resistance. Recapitulating GBM chemoresistance in a controlled environment is thus essential in understanding the mechanism of chemoresistance. Herein, we present a hybrid microphysiological model of chemoresistant GBM-on-a-chip (HGoC) by directly co-culturing TMZ-resistant GBM spheroids with healthy neurons to mimic the microenvironment of both the tumor and the surrounding healthy tissue. We characterized the model with proteomics, lipidomics, and secretome assays. The results showed that our artificial model recapitulated the molecular signatures of recurrent GBM in humans. Both showed alterations in vesicular transport and cholesterol pathways, mitotic quiescence, and a switch in metabolism to oxidative phosphorylation associated with a transition from mesenchymal to amoeboid. This is the first report to unravel the interplay of all these molecular changes as a mechanism of chemoresistance in glioblastoma. Moreover, we have shown that the acquisition of resistance increases invasiveness and the presence of neurons decreases this property.

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A multi-omics analysis of glioma chemoresistance using a hybrid microphysiological model of glioblastoma

Shojaei

Amereh²,

Alizadeh

et al. 2022

Preprint

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show abstract

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Of crows and tools

Cited by 1 publication

References 17 publications

A multi-omics analysis of glioma chemoresistance using a hybrid microphysiological model of glioblastoma

A multi-omics analysis of glioma chemoresistance using a hybrid microphysiological model of glioblastoma

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