Of humans and canines: Immunohistochemical analysis of PCNA, Bcl-2, p53, cytokeratin and ER in mammary tumours

Ramasamy, Kumaraguruparan; Prathiba, D; Nagini, Siddavaram

doi:10.1016/j.rvsc.2005.08.002

Cited by 60 publications

(60 citation statements)

References 39 publications

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“…The p53 tumor suppressor gene encodes a protein which normally regulates cell cycle and programmed cell death, and its mutations are known to contribute to the carcinogenic process of various organs, including the mammary gland (Greenblatt et al, 1994). In CMT, p53 mutations have been detected in both benign and malignant types (Muto et al, 2000;Lee and Kweon, 2002;Kumaraguruparan et al, 2006).…”

Section: Genetic Factorsmentioning

confidence: 99%

Canine Mammary Tumors: Risk Factors, Prognosis and Treatments

2016

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Mammary tumors are the most common neoplasm in the female dog, with a median age of appearance between 9 and 11 years. They may appear as single or multiple nodules, and posterior mammary glands are more frequently affected than anterior glands. Both benign and malignant tumors may occur in the dog, and according to histological criteria, approximately 50% of the tumors are malignant. Mammary gland tumors tend to be heterogeneous in their pathological characteristics and clinical behavior. Different hormones and growth factors play a key role in the development of this neoplasm, however, the mechanism by which they influence tumor growth and their possible prognostic value are still under study. Besides, new therapeutic options for each particular tumor type are being developed. The aim of this article is to review pathological, prognostic and therapeutic aspects of canine mammary neoplasms.

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Section: Genetic Factorsmentioning

confidence: 99%

Canine Mammary Tumors: Risk Factors, Prognosis and Treatments

2016

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“…Em média, os tumores têm maior incidência após a menopausa para as mulheres e entre os 10 e 11 anos para as cadelas (COHEN et al 1974;KUMAR et al, 2005). A exposição a estrógenos está associada ao desenvolvimento e progressão dos tumores de mama humanos e caninos (KUMARAGURUPARAN et al, 2006). A fase de desenvolvimento do ciclo estral provavelmente tem muita influência nas neoplasias mamárias em caninas (MOULTON, 1990).…”

Section: -Neoplasias Mamáriasunclassified

“…Também devem ser avaliados fatores que interferem na proliferação celular, apoptose e desregulação da diferenciação celular (BENJAMIN et al, 1999;PHILIBERT et al, 2003;CHANG et al, 2005;LAS MULAS et al, 2005;KUMARAGURUPARAN et al 2006). Segundo Lester (2005), os fatores prognósticos são os mais fortes preditores de óbitos por câncer de mama em mulheres e são incorporados ao sistema de estadiamento da American Joint Committee on Cancer (AJCC).…”

Section: -Neoplasias Mamáriasunclassified

Immunostaining of micrometastases of spontaneous mammary neoplasias of bitches in lymph nodes through receptor CD44

Magalhães¹,

Silveira²,

Alessi³

2016

Pubvet

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The CD44 is an adhesion molecule, which belongs to the multifunctional family of transmembrane glycoproteins and is closely related to tumor progression. The aim of this study was to evaluate the immunostaining for CD44 in malignant mammary neoplasia of female dogs, with and without metastasis at the regional lymph nodes, assign it as a prognostic factor in early detection of metastases; relate it with the immunostaining for MMP-9, e-cadherin and VEGF. The experimental groups were: dogs with mammary tumor, with (Group M) or without metastasis (Group N) detectable in lymph nodes. The mammary tumors were classified according to the World Health Organization. The technique of immunohistochemistry was used in paraffin-embedded samples. To determine the percentage of immunostaining was considered only the neoplastic epithelial cells. For the CD44 antibody was used the immunostaining on T lymphocytes in lymph nodes of both groups. The immunostaining on T lymphocytes were higher in group N and lower in group M. There was significant increase in CD44 immunostaining in the site of the primary tumor (neoplastic epithelial cells) for metastasis, as well as the staining of MMP-9 and E-cadherin. It was concluded that CD44 may act together with other molecules, such as MMP-9 and E-cadherin. It is proposed that early detection of micrometastasis is made on T lymphocytes in lymph nodes draining malignant mammary neoplasms in female dogs.

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“…In comparative research on human and canine mammary tumours (CMTs), it was reported that CMTs are better suited than rodent models to the evaluation of the molecular mechanism of carcinogenesis (10,11,19).…”

Section: Introductionmentioning

confidence: 99%

Investigation of human papillomaviruses (HPV), mouse mammary tumour virus (MMTV), Epstein–Barr virus (EBV), and human polyomavirus entities in canine mammary tumours

Sönmez¹,

Altan

Yıldırım³

et al. 2016

Journal of Veterinary Research

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Introduction: The aim of the study was to investigate the presence of human papillomaviruses (HPV), mouse mammary tumour virus (MMTV), Epstein-Barr virus (EBV), and human polyomavirus BK in canine mammary tumours (CMTs) and to correlate the results of histopathological classification with the results of virological examination. Material and Methods: Eighty CMTs and ten normal canine mammary gland samples were evaluated using histopathological methods and TaqMan real-time PCR analysis. Results: The results indicated that all mammary tumours and normal mammary tissue samples were negative for HPV16 and other HPV, EBV, human polyomavirus, and human mammary tumour virus strains. Conclusion: Further studies should be performed to investigate the existence of other strains of HPV, EBV, and human polyomavirus in CMTs.

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Of humans and canines: Immunohistochemical analysis of PCNA, Bcl-2, p53, cytokeratin and ER in mammary tumours

Cited by 60 publications

References 39 publications

Canine Mammary Tumors: Risk Factors, Prognosis and Treatments

Canine Mammary Tumors: Risk Factors, Prognosis and Treatments

Immunostaining of micrometastases of spontaneous mammary neoplasias of bitches in lymph nodes through receptor CD44

Investigation of human papillomaviruses (HPV), mouse mammary tumour virus (MMTV), Epstein–Barr virus (EBV), and human polyomavirus entities in canine mammary tumours

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