“…In an editorial that appeared in the inaugural issue, Richard Wenzel and William Schaffner described the then-current state of knowledge in our field and the mission of the journal: “Our present knowledge is limited and our working assumption is that by rigorously addressing basic questions we may find truth. It is hoped that these pages will provide a vehicle for the testing of ideas and the emergence of new insights with practical applications.” 1 Over the 44 years that have passed since that was written, the fields of infection prevention, healthcare epidemiology, and antimicrobial stewardship (a term not yet coined in 1980) have made significant advancements. Healthcare-associated infection (HAI) measurement has become standard work for hospitals, and national metrics for HAIs now exist.…”