Of the Catarrhus Æstivus, or Summer Catarrh

Bostock, John

doi:10.1177/09595287280140p204

Cited by 58 publications

(26 citation statements)

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“…In 1819, BOSTOCK [2] provided the first clinical description of what is now recognised as seasonal allergic rhinitis and asthma. About 10 years later, the terminology of hay fever and hay asthma appeared in the English language [3] because of the relationship of these allergic symptoms to the haying season. In 1873, BLACKLEY [4] published his classic monograph documenting that pollen, grass pollen in particular, was the cause of these seasonal symptoms.…”

Section: Introductionmentioning

confidence: 99%

Allergen-induced airway responses

2015

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Environmental allergens are an important cause of asthma and can contribute to loss of asthma control and exacerbations. Allergen inhalation challenge has been a useful clinical model to examine the mechanisms of allergen-induced airway responses and inflammation. Allergen bronchoconstrictor responses are the early response, which reaches a maximum within 30 min and resolves by 1-3 h, and late responses, when bronchoconstriction recurs after 3-4 h and reaches a maximum over 6-12 h. Late responses are followed by an increase in airway hyperresponsiveness. These responses occur when IgE on mast cells is cross-linked by an allergen, causing degranulation and the release of histamine, neutral proteases and chemotactic factors, and the production of newly formed mediators, such as cysteinyl leukotrienes and prostaglandin D 2 . Allergen-induced airway inflammation consists of an increase in airway eosinophils, basophils and, less consistently, neutrophils. These responses are mediated by the trafficking and activation of myeloid dendritic cells into the airways, probably as a result of the release of epithelial cell-derived thymic stromal lymphopoietin, and the release of pro-inflammatory cytokines from type 2 helper T-cells. Allergen inhalation challenge has also been a widely used model to study potential new therapies for asthma and has an excellent negative predictive value for this purpose. @ERSpublications Environmental allergens are an important cause of asthma

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Section: Introductionmentioning

confidence: 99%

Allergen-induced airway responses

2015

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“…It must be confessed that he was probably famous in his day more because of his industry than his originality, as the Dictionary o f National Biography' s waspish review [2] suggests. Nev ertheless, his observations on hay fever [36,37] and his insight into nephrotic syndrome assure him of a place in medical history, as Pettigrew recognized by including him in his series of medical portraits [8] of the great physicians of his and previous eras. On his death in 1846, a colleague writing under the pseudonym of Athanaeum wrote in the Gentleman's Magazine [4]: 'In private life he was respected and beloved.…”

Section: Discussionmentioning

confidence: 99%

“…Some of his early enquiries arose out of observations made in the fever hos pital in Liverpool. Perhaps Bostock's best known contribution to medical science, apart from his work with Bright, is his description of his own case of hay fever in 1819 [36,37], Finn [38] recently put this paper in context, repeating the early sug gestions of Elliotson [39] and others that this complaint was rare until the pollution introduced by the industrial revolution. Finn [38] Perhaps he had suffered himself from these!…”

Section: Other Scientific Work Of Bostockmentioning

confidence: 99%

John Bostock MD FRS (1773-1846): Physician and Chemist in the Shadow of a Genius

1994

Am J Nephrol

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John Bostock has a reasonable claim to being one of the first chemical pathologists. Most of his work was done before that of William Prout, with whom both he and Bright were in contact. Bostock’s work was done about the same time as that of his friends and colleagues Marcet and Wollaston. Although others, notably Cruickshank, Wells and Blackall had previously studied the chemistry of normal and pathological urine, the breadth and detail of Bostock’s observations were unprecedented, and he and Wells were the first to relate findings in the urine in disease to findings in the serum. Bostock, however, was the first to realize the relationship between the diminution of urea in urine as it rose (or in his terms, appeared) in the blood, while the albumin in the blood fell as that in the urine increased.

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“…In a later paper in 1828 he described the use of the popular phrase 'hay fever' but preferred to call it 'summer catarrh' [53]. Human sensitivity to roses and other flowers had been reported as early as 1565, but Bostock in 1819, in a case report in which he was the subject, was the first to describe hay fever as a disease with a definite symptomatology.…”

Section: The Beginning Of Our Concepts Of Hay Fever and Asthma As Allmentioning

confidence: 99%

Elements of the history of our present concepts of anaphylaxis, hay fever and asthma

Becker

1999

Clin Experimental Allergy

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Of the Catarrhus Æstivus, or Summer Catarrh

Cited by 58 publications

References 0 publications

Allergen-induced airway responses

Allergen-induced airway responses

John Bostock MD FRS (1773-1846): Physician and Chemist in the Shadow of a Genius

Elements of the history of our present concepts of anaphylaxis, hay fever and asthma

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