2020
DOI: 10.1016/j.hrthm.2020.07.022
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Off-label dosing of non–vitamin K antagonist oral anticoagulants and clinical outcomes in Asian patients with atrial fibrillation

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Cited by 69 publications
(82 citation statements)
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“…The flow chart of the literature retrieval of this meta‐analysis is shown in Supplementary Figure 1. A total of 11 studies were included in this meta‐analysis 6‐8,11,14,15,22‐26 . The specific baseline characteristics of these included studies are shown in Table 1.…”
Section: Resultsmentioning
confidence: 99%
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“…The flow chart of the literature retrieval of this meta‐analysis is shown in Supplementary Figure 1. A total of 11 studies were included in this meta‐analysis 6‐8,11,14,15,22‐26 . The specific baseline characteristics of these included studies are shown in Table 1.…”
Section: Resultsmentioning
confidence: 99%
“…In these years, more and more researchers have explored the effect of non‐recommended low dose or non‐recommended high dose of DOACs among patients with AF 5‐15 . However, the findings of those observational studies are sometimes quite different; and thus, the effectiveness and safety profiles among non‐recommended doses of DOACs remain unclear, leaving physicians with difficulties in decision‐making regarding the choice of DOAC doses.…”
Section: Introductionmentioning
confidence: 99%
“…Taking the study performed by Chan et al, which enrolled 11,275 Taiwanese AF patients receiving NOACs, for example, ≈27% and ≈5% of them were treated with underdosing and overdosing of NOACs, respectively. 21 Compared with on-label dosing, underdosing of NOACs was associated with a significantly higher risk of IS/SE (hazard ratio [HR] 1.59; 95% confidence interval [CI] 1.25-2.02; P<0.001), whereas overdosing NOACs was associated with a significantly higher risk of major bleeding (adjusted HR 2.01; 95% CI 1.13-3.56; P=0.017). 21 Likewise, a study from a tertiary medical center in South Korea also demonstrated that underdosing of NOACs was associated with a 2.5-fold increased risk of thromboembolism compared with warfarin.…”
Section: Importance Of Prescribing On-label Dosing Of Noacsmentioning
confidence: 99%
“…21 Compared with on-label dosing, underdosing of NOACs was associated with a significantly higher risk of IS/SE (hazard ratio [HR] 1.59; 95% confidence interval [CI] 1.25-2.02; P<0.001), whereas overdosing NOACs was associated with a significantly higher risk of major bleeding (adjusted HR 2.01; 95% CI 1.13-3.56; P=0.017). 21 Likewise, a study from a tertiary medical center in South Korea also demonstrated that underdosing of NOACs was associated with a 2.5-fold increased risk of thromboembolism compared with warfarin. 20 data reveal that underdosing is not uncommon, and has been reported in up to 50% of AF patients treated with NOACs.…”
Section: Importance Of Prescribing On-label Dosing Of Noacsmentioning
confidence: 99%
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