2013
DOI: 10.1186/1471-2458-13-631
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Off-label medicine use in children and adolescents: results of a population-based study in Germany

Abstract: BackgroundPopulation-based self-reported data on off-label medicine use independent from health care provisions are lacking. The purpose of this study is to investigate off-label medicine use in children and adolescents in Germany in a non-clinical setting and to identify prevalence, determinants and spectrum of off-label medicine use.MethodsData were obtained from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) conducted by the Robert Koch Institute (2003–2006). 17,450 … Show more

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Cited by 86 publications
(106 citation statements)
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References 36 publications
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“…Study had done by Knopf et al show these results 50.42% and 24.70% respectively. 16 So, our study shows similar common error of overdosing in respiratory drug prescription. Antiamoebic drugs were prescribed in overdose 0.66% and in under dose 1.93%.…”
supporting
confidence: 51%
See 1 more Smart Citation
“…Study had done by Knopf et al show these results 50.42% and 24.70% respectively. 16 So, our study shows similar common error of overdosing in respiratory drug prescription. Antiamoebic drugs were prescribed in overdose 0.66% and in under dose 1.93%.…”
supporting
confidence: 51%
“…If medication is under-dosed possibly no therapeutic benefit but a risk for adverse drug reactions (ADRs) could occur, as those often are independent of the dose. 16 Under dose profile as shown in Fig.1 (a); majority part is contributed by Antihistaminic drugs (44.48%). The first generation of antihistamines has never been clinically tested in children; nevertheless, it is widely used.…”
mentioning
confidence: 99%
“…19 Beyond this observation, more information about the underlying causes of off-label prescribing is needed. In the present study, individual factors related to the number of medications or certain medical conditions were found to be associated with off-label prescribing.…”
Section: Perspectivesmentioning
confidence: 99%
“…По общему количеству случаев применения off-label имеются различия в использовании препара-тов, согласно классификации АТХ, в разных возрастных группах: в возрасте до 2 лет наиболее часто в рамках off-label применений использовались препараты для лечения органов чувств (код S), препараты для лечения заболеваний респираторной системы (код R) и противо-микробные препараты для системного использования (код J). У детей в возрасте от 3 до 10 лет чаще с нару-шением инструкции назначались лекарственные пре-параты, влияющие на пищеварительный тракт и обмен веществ (код А), а также препараты кода R и S, в стар-шей возрастной группе (от 11 до 17 лет) наряду с пре-паратами для лечения заболеваний пищеварительного тракта и органов чувств использовались ЛП для терапии заболеваний кожи (класс D) [17].…”
Section: актуальность проблемыunclassified