2020
DOI: 10.1016/j.therap.2020.05.002
|View full text |Cite
|
Sign up to set email alerts
|

“Off-label” use of hydroxychloroquine, azithromycin, lopinavir-ritonavir and chloroquine in COVID-19: A survey of cardiac adverse drug reactions by the French Network of Pharmacovigilance Centers

Abstract: Introduction.-COVID-19 is an unprecedented challenge for physicians and scientists. Several publicized drugs are being used with not much evidence of their efficacy such as hydroxychloroquine, azithromycin or lopinavir-ritonavir. Yet, the cardiac safety of these drugs in COVID-19 deserves scrutiny as they are known to foster cardiac adverse ADRs, notably QTc interval prolongation on the electrocardiogram and its arrhythmogenic consequences. Methods.-Since March 27th, 2020, the French Pharmacovigilance Network … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

9
107
0
23

Year Published

2020
2020
2023
2023

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 126 publications
(139 citation statements)
references
References 41 publications
9
107
0
23
Order By: Relevance
“…Azithromycin is widely used and is generally considered a safe medication. There are, however, occasional adverse effects 10 . As with almost all antibiotics, diarrhea, nausea, vomiting, and headache may ensue, as may occasional urticaria and other skin eruptions.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Azithromycin is widely used and is generally considered a safe medication. There are, however, occasional adverse effects 10 . As with almost all antibiotics, diarrhea, nausea, vomiting, and headache may ensue, as may occasional urticaria and other skin eruptions.…”
Section: Discussionmentioning
confidence: 99%
“…As with almost all antibiotics, diarrhea, nausea, vomiting, and headache may ensue, as may occasional urticaria and other skin eruptions. Serious side effects are uncommon; however, they may include cardiac arrhythmias, especially in the elderly and in those with preexisting QT interval prolongation, bradycardia, low serum potassium or magnesium, and in individuals who are taking certain antiarrhythmic drugs 5,10 . In the search for a safe, effective treatment for individuals with early mild or moderate COVID‐19, however, azithromycin is one of the most promising 11…”
Section: Discussionmentioning
confidence: 99%
“…Wide use of HCQ will expose some patients to potentially fatal adverse reactions, including ventricular arrhythmias and cardiac arrest, especially when prescribed with AZ (Gerard et al 2020). The combination of HCQ and AZ has been designed for the treatment of COVID-19 due to their synergistic antimicrobial properties (Nakornchai and Konthiang 2006).…”
Section: Discussionmentioning
confidence: 99%
“…Both drugs have been associated with QT interval prolongation and arrhythmogenic effects (1,2). However, the actual risk of ventricular arrhythmias using this combination is unclear (3,4). Here we report QT interval prolongation and arrhythmia safety results in patients with COVID-19 treated with the combination of HCQ and AZI using close monitoring and arrhythmia risk management plan.…”
Section: Introductionmentioning
confidence: 86%