Off‐Label Use of Ultrasound Contrast Agents for Intravenous Applications in Children

Abstract

Our results support the idea that the IV use of US contrast agents in children is safe, feasible, diagnostically robust, and effective.

Subdermal Ultrasound Contrast Agent Injection for Sentinel Lymph Node Identification: An Analysis of Safety and Contrast Agent Dose in Healthy Volunteers

“…Hence, this study aimed to evaluate the subdermal use of Sonazoid in CEUS to identify SLNs and, therefore, to be used in the future as an alternative to blue dye and/or radiopharmaceuticals. The safety of UCAs by intravascular or intravesical administration has been studied extensively, and the safety profile is excellent, with a low incidence of AEs. The side effects reported with UCAs are, in general, nonserious and transient and resolve spontaneously without residual effects …”

Microbubbles in macrocysts – Contrast-enhanced ultrasound assisted sclerosant therapy of a congenital macrocystic lymphangioma: a case report

“…There is a long history of safe use of SonoVue® in echocardiography [5] and recent clinical studies document the drug safety of SonoVue® in children [6, 7]. Thus, in our opinion, the advantages of preinterventional CEUS in CCL, including improved application guidance of the sclerosant agent and reduced risk of periinterventional infection due to unnecessary punctions, justify off-label use of SonoVue® in CCL in children.…”

AIUM Practice Parameter for the Performance of Contrast‐Enhanced Ultrasound Examinations

“…Ultrasound contrast agents have a similar safety profile in children Intravesical and intracavitary administration …”