Off-Label Uses of Topical Vitamin D in Dermatology: A Systematic Review

Wat, Heidi; Dytoc, Marlene

doi:10.2310/7750.2013.13109

Cited by 31 publications

(34 citation statements)

References 167 publications

(234 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Medical therapy of such event includes topical treatment with anti-inflammatory creams, lotions as well as topical corticosteroids (Carroll and Fleischer, 2004;Wat and Dytoc, 2014).…”

Section: Introductionmentioning

confidence: 99%

Ameliorating Effect of Achillea fragrantissima Against Benzene-Induced Skin Irritation: Histological Study

Al-Shathly¹,

Alqahtani²

2017

Adv. Pharm. Ethnomed

View full text Add to dashboard Cite

| Organic solvents such as car fuel, which contains benzene and other solvents were known to cause skin irritation and contact dermatitis. Although anti-inflammatory steroids topical medications were used, they may result in side effects in susceptible persons. Herbal preparation was tried in literature. In the present study, Achillea fragrantissima, a wild plant in some areas of Saudi Arabia was used to speed slow-healing wounds. Thus, the study was designed to investigate its efficacy to treat experimentally induced benzene-dermatitis in mice skin. Twenty-five adult mice were shaved and animals were divided into GI as control and GII as benzene painted. The later was further divided into four subgroups; untreated, steroidal medicinal cream treated, a group treated with olive oil extract of Achillea (dried plant soaked in olive oil) and a group treated with olive oil only. Gross and histopathological observation were used to evaluate the treatment effects. Benzene painting produced skin hardening, scaling, epidermal hyperplasia and inflammatory reaction in skin dermis. Decrease in the hypodermal adipose tissue thickness was observed, those pathological changes were much improved or even absent in treated mice. Such results are similar to that observed in the group treated by medicinal cream. Achillea plant could be a source of future effective anti-dermatitis cream medicinal formulation against benzene-induced dermatitis. Olive oil extract of Achillea will be tested and compared to olive oil alone to prove the hypothesis.

show abstract

“…Medical therapy of such event includes topical treatment with anti-inflammatory creams, lotions as well as topical corticosteroids (Carroll and Fleischer, 2004;Wat and Dytoc, 2014).…”

Section: Introductionmentioning

confidence: 99%

Ameliorating Effect of Achillea fragrantissima Against Benzene-Induced Skin Irritation: Histological Study

Al-Shathly¹,

Alqahtani²

2017

Adv. Pharm. Ethnomed

View full text Add to dashboard Cite

show abstract

“…A systematic review involving 165 articles showed a moderate to strong recommendation for the use of topical vitamin D analogues in combination with corticosteroids and phototherapy in vitiligo and as monotherapy for ichthyoses, morphea, pityriasis alba, prurigo nodularis, and polymorphous light eruption. It may be ineffective in the treatment of actinic keratosis, seborrheic keratosis, lichen planus, seborrheic dermatitis, alopecia areata, chemotherapy‐induced alopecia, and hypertrophic scars …”

Section: Off‐label Prescriptions In Dermatologymentioning

confidence: 99%

Controversies in off‐label prescriptions in dermatology: the perspective of the patient, the physician, and the pharmaceutical companies

França

Litewka

2018

Int J Dermatology

View full text Add to dashboard Cite

The term "off-label drug use" involves the prescription of medications for unapproved indications or in unapproved dosage, dosage form, or route of administration. Off-label medications are common in the management of dermatologic diseases. In the recent years, new indications for botulinum toxin, biologics, spironolactone, topical calcineurin, and topical vitamin D analogues emerged, and these drugs are being used off-label to treat a variety of conditions. The high cost and long time required for the approval discourage pharmaceutical companies from developing studies and pursuing the approval by regulatory agencies. Patients and physicians may have a different perspective regarding the off-label use of medications. The ethical discussion is based on the different opinions concerning the need for informed consent by the patient and how this could be applicable in the clinical practice.

show abstract

“…Additionally, anti‐inflammatory effects from the inhibition of cytotoxic T‐cells and NK cells and the downregulation of inflammatory cytokines were demonstrated (Bagot, Charue, Lescs, Pamphile, & Revuz, ; Rostkowska‐Nadolska et al, ). Calcipotriol, a synthetic topical vitamin D derivative, has been widely used in the treatment of psoriasis and has been reported to achieve beneficial effects in the treatment of other inflammatory diseases, such as morphea, vitiligo, and ichthyosis (Holm & Jemec, ; Wat & Dytoc, ). Generally, topical vitamin D analogues are well tolerated; nevertheless, common side effects after prolonged or excessive application are irritation and desquamation.…”

Section: Introductionmentioning

confidence: 99%

“…Calcipotriol, a synthetic topical vitamin D derivative, has been widely used in the treatment of psoriasis and has been reported to achieve beneficial effects in the treatment of other inflammatory diseases, such as morphea, vitiligo, and ichthyosis (Holm & Jemec, 2002;Wat & Dytoc, 2014). Generally, topical vitamin D analogues are well tolerated; nevertheless, common side effects after prolonged or excessive application are irritation and desquamation.…”

Section: Introductionmentioning

confidence: 99%

Calcipotriol ointment shows comparable efficacy to topical steroids in chronic hand eczema

Juntongjin

Pongprasert

2019

Dermatologic Therapy

View full text Add to dashboard Cite

Topical potent corticosteroids are the mainstay of treatment for chronic hand eczema (CHE). However, there are numerous adverse effects associated with the chronic use of topical corticosteroids. Calcipotriol has been widely used in psoriasis and has been reported to achieve beneficial effects in several inflammatory diseases. This study aimed to evaluate the efficacy and safety of calcipotriol ointment compared to desoximetasone ointment in the treatment of CHE. Patch testing was performed in all recruited subjects. Then, each hand of the patient was randomly allocated for the application of either calcipotriol ointment or desoximetasone ointment twice daily for 8 weeks. Recurrence was assessed 4 weeks after discontinuation of the treatment. The Hand eczema severity index (HECSI) scores, quartile grading assessments and digital photographs were evaluated. Adverse reactions were also monitored. A total of 13 participants completed the protocol. Mean HECSI scores revealed up to a 75% reduction in both treatments (p < .001) without significant differences between the groups (p > .05). Approximately 70% of the subjects reported more than 75% improvement with calcipotriol at the end of the treatment. Mild scaling and mild dryness were the most common reactions found with calcipotriol and desoximetasone, respectively. In conclusion, calcipotriol ointment is safe and as effective as desoximetasone ointment. Calcipotriol ointment may be an alternative treatment option for CHE.

show abstract

Off-Label Uses of Topical Vitamin D in Dermatology: A Systematic Review

Abstract: Topical vitamin D analogues have an important role in the off-label treatment of dermatologic disease, but higher quality studies are still required.

Cited by 31 publications

References 167 publications

Ameliorating Effect of Achillea fragrantissima Against Benzene-Induced Skin Irritation: Histological Study

Ameliorating Effect of Achillea fragrantissima Against Benzene-Induced Skin Irritation: Histological Study

Controversies in off‐label prescriptions in dermatology: the perspective of the patient, the physician, and the pharmaceutical companies

Calcipotriol ointment shows comparable efficacy to topical steroids in chronic hand eczema

Contact Info

Product

Resources

About