Off-pump versus on-pump coronary artery bypass grafting: oxidative stress and renal function

Abstract

Only mild signs of oxidative stress and no renal dysfunction were found during and after off-pump CABG compared with on-pump CABG.

Malondialdehyde kinetics following coronary artery bypass grafting and its relation to osteopontin

“…Marked postoperative increases in both MDA and troponin concentrations have already been reported [1,7]. In the present study, we not only observed a net increase in both biomarkers between baseline and at 72 h but also a strong positive correlation between these changes, suggesting that free radical activation may result in myocardial injury and as a consequence, in further adverse outcomes.…”

“…Cardiac surgery is associated with inflammation and oxidative stress [1]. Significant global ischemia followed by reperfusion during coronary artery bypass graft (CABG) surgery leads to a burst of oxygen free radical generation and subsequent myocardial dysfunction [2].…”

Risk factors for deterioration of renal function after coronary artery bypass grafting

“…Several risk factors for impairment of renal function after coronary artery bypass grafting (CABG) have been identified, of which female sex, age, diabetes mellitus, hypertension, preoperative creatinine clearance (CrCl) <50 ml min À1 , impaired left ventricular function, need for intra-aortic balloon pump (IABP) and re-exploration are most often mentioned [1][2][3][4]. Several studies state that deterioration of renal function occurs more often after conventional coronary artery bypass operation with the use of extracorporeal circulation (ECC) than after off-pump coronary artery bypass (OPCAB) [5][6][7][8][9] although others could not confirm this statement [3,4,10].…”

Dobutamine improves thoracic aortic blood flow during off-pump coronary artery bypass surgery: results of a prospective randomised controlled trial

“…Haemodynamic changes during heart displacement have been studied in both animals and humans [8][9][10]23], and were found to be significant during the marginal and right coronary artery anastomoses rather than during the LAD anastomosis; however, they were thought always to be within the physiologic limits. Our study confirms the findings of those previous studies in that respect.…”