2013
DOI: 10.1056/nejmoa1211666
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Off-Pump versus On-Pump Coronary-Artery Bypass Grafting in Elderly Patients

Abstract: In patients 75 years of age or older, there was no significant difference between on-pump and off-pump CABG with regard to the composite outcome of death, stroke, myocardial infarction, repeat revascularization, or new renal-replacement therapy within 30 days and within 12 months after surgery. (Funded by Maquet; GOPCABE ClinicalTrials.gov number, NCT00719667.).

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Cited by 457 publications
(293 citation statements)
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“…In GOPCABE (German Off‐Pump CABG in Elderly Trial), a German RCT including only patients aged >75 years, there was no significant difference in the primary composite end point of death, stroke, MI, or new renal replacement therapy (7.8% versus 8.2%, P =0.74) at 30 days41 and no differences in the individual components of the composite end point (Table 1). However, there was an increased number of repeat revascularizations with OPCAB (1.3% versus 0.4%, P =0.04), a finding also observed in CORONARY (0.7% versus 0.2%, P =0.01).…”
Section: Comparison Of Short‐term Clinical Outcomes Of On‐ and Off‐pumentioning
confidence: 99%
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“…In GOPCABE (German Off‐Pump CABG in Elderly Trial), a German RCT including only patients aged >75 years, there was no significant difference in the primary composite end point of death, stroke, MI, or new renal replacement therapy (7.8% versus 8.2%, P =0.74) at 30 days41 and no differences in the individual components of the composite end point (Table 1). However, there was an increased number of repeat revascularizations with OPCAB (1.3% versus 0.4%, P =0.04), a finding also observed in CORONARY (0.7% versus 0.2%, P =0.01).…”
Section: Comparison Of Short‐term Clinical Outcomes Of On‐ and Off‐pumentioning
confidence: 99%
“…Of note, no reduction in stroke was noted both in hospital and at 1 year (CORONARY: 1.5% versus 1.7%; [hazard ratio (HR): 0.90; 95% confidence interval (CI), 0.57–1.41]; GOPCABE: 3.5% versus 4.4%; P =0.26) 41, 42…”
Section: Comparison Of Short‐term Clinical Outcomes Of On‐ and Off‐pumentioning
confidence: 99%
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“…Наибо-лее информативные рандомизированные исследования включали как пациентов с относительно невысоким риском вмешательства (ROOBY), так и больных стар-ше 75 лет со значительно худшими характеристиками (GOPCABE). Эти исследования, как и большинство ме-таанализов, продемонстрировали, что ранние и годич-ные результаты КШ off-pump сравнимы с результатами стандартных операций, однако в группах off-pump от-мечена большая неполная реваскуляризация, необхо-димость повторных вмешательств и худшая проходи-мость шунтов [44,45]. Недавно опубликованная работа B.H.…”
Section: тактика операцииunclassified
“…Two additional prospective RCTs, focusing on elderly and high-risk patients, had failed to demonstrate a difference in 30-day or 1-year outcomes when on-or off-pump CABG was performed by experienced teams [50,51]. Interestingly, based on some of the same data available to the American group [47,52], the Europeans were more convinced of the potential value of off-pump surgery in high-risk patients, especially with regard to stroke, and recommended that off-pump CABG be 'considered' for subgroups of high-risk patients in high-volume off-pump centres as a COR IIa based on LOE B.…”
Section: On-versus Off-pumpmentioning
confidence: 99%