ObjectivesUnstable trimalleolar fractures are relatively complex and more difficult to manage if die‐punch fracture is present. We aimed to evaluate the curative effect of homeopathic ankle dislocation on the unstable trimalleolar fractures involving posterior die‐punch fragments.MethodsA total of 124 patients diagnosed with unstable trimalleolar fractures combined with post‐die punch fragment between June 2008 and June 2020 were retrospectively included. Patients who received homeopathic ankle dislocation were named as the experimental group, and patients who accepted conventional treatment were control group. The fracture healing time, wound healing, American Orthopedic Foot and Ankle Society ankle‐hindfoot scale (AOFAS), visual analogue scale (VAS), the Kellgren–Lawrence arthritis grading scale (KLAGS) and short‐form 36 score (SF‐36) scores were collected. Student t‐test was used for fracture healing time. Wound healing and SF‐36 were compared using the Mann–Whitney test. Repeated measurement analysis of variance (ANOVA) was used for AOFAS and VAS. χ2‐test was used for KLAGS.ResultsAOFAS showed statistically significant differences between the two groups (p = 0.001). In non‐weight‐bearing and weight‐bearing conditions, VAS scores were significant different between the two groups, and there was an interaction between group and time point (p < 0.001). The experimental group was superior to the control group in terms of physical function (p = 0.022), role‐physical (p = 0.018), general health (p = 0.001) and social function (p = 0.042).The operation time of experimental group was shorter than that of control group (p < 0.001).ConclusionHomeopathic ankle dislocation is used for the unstable trimalleolar fractures involving posterior die‐punch fragment, which can provide better functional outcomes while shortening the operation time and recovery period.