Office-based optical coherence tomographic imaging of human vocal cords

Guo, Shan; Hutchison, R.; Jackson, Ryan P.; Kohli, A. P.; Sharp, Tristan A.; Orwin, Elizabeth; Haskell, Richard C.; Chen, Zhongping; Wong, Brian J. F.

doi:10.1117/1.2200371

Cited by 37 publications

(34 citation statements)

References 7 publications

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“…The OCT was shown to work in test persons, but the use of two endoscopes in parallel leads to a bulky setup which is hard to use in the limited space of the oral cavity as the authors discuss. 12 Additional challenges arise from movement of the operator as well as the patient. In the setup of Guo et al, 12 the movement was restricted by stiff fixation of the endoscopes and the patient's head by a forehead rest.…”

Section: Introductionmentioning

confidence: 99%

“…12 Additional challenges arise from movement of the operator as well as the patient. In the setup of Guo et al, 12 the movement was restricted by stiff fixation of the endoscopes and the patient's head by a forehead rest. First, OCT scans of awake patients were shown but were still disturbed by motion artifacts because of the slow frame rate of 1 Hz.…”

Section: Introductionmentioning

confidence: 99%

“…The first rigid office-based OCT endoscope for application on awake patients was developed by Guo et al 12 Laryngoscopy or video-laryngoscopic images were used to guide the OCT imaging using two parallel endoscopes. The OCT was shown to work in test persons, but the use of two endoscopes in parallel leads to a bulky setup which is hard to use in the limited space of the oral cavity as the authors discuss.…”

Section: Introductionmentioning

confidence: 99%

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Automated working distance adjustment enables optical coherence tomography of the human larynx in awake patients

et al. 2015

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Abstract. Optical coherence tomography (OCT) provides structural information of laryngeal tissue which is comparable to histopathological analysis of biopsies taken under general anesthesia. In awake patients, movements impede clinically useful OCT acquisition. Therefore, an automatic compensation of movements was implemented into a swept source OCT-laryngoscope. Video and OCT beam path were combined in one tube of 10-mm diameter. Segmented OCT images served as distance sensor and a feedback control adjusted the working distance between 33 and 70 mm by synchronously translating the reference mirror and focusing lens. With this motion compensation, the tissue was properly visible in up to 88% of the acquisition time. During quiet respiration, OCT contrasted epithelium and lamina propria. Mean epithelial thickness was measured to be 109 and 135 μm in female and male, respectively. Furthermore, OCT of mucosal wave movements during phonation enabled estimation of the oscillation frequency and amplitude. Regarding clinical issues, the OCT-laryngoscope with automated working distance adjustment may support the estimation of the depth extent of epithelial lesions and contribute to establish an indication for a biopsy. Moreover, OCT of the vibrating vocal folds provides functional information, possibly giving further insight into mucosal behavior during the vibratory cycle.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Automated working distance adjustment enables optical coherence tomography of the human larynx in awake patients

et al. 2015

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“…Such a forward scanning probe was used to establish a quantitative comparison between in vivo OCT measurements of epithelial thickness and light microscopy measurements on excised specimens [186]. To address a need for early cancer detection, a rigid OCT probe was developed that could be attached to the laryngoscope for office-based examination of patients without need of anesthesia [187]. The main challenge for the device was a limited field of view and short working distance of the OCT probe in comparison to the laryngoscope that caused difficulties in correct placement of the device.…”

Section: Otolaryngologymentioning

confidence: 99%

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Gora¹,

Suter²,

Tearney³

et al. 2017

Biomed. Opt. Express

262

203

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Abstract:In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forwardviewing probes, along with different scanning mechanisms (proximal-scanning versus distalscanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions. Representative applications in several organ systems are presented, such as in the cardiovascular, digestive, respiratory, and reproductive systems. A brief outlook of the field of endoscopic OCT is also discussed. References and links 1. T. Cao and H. L. Tey, "High-definition optical coherence tomography -an aid to clinical practice and research in dermatology," J. Dtsch. Dermatol. Ges. 13(9), 886-890 (2015). 2. J. Olsen, L. Themstrup, and G. B. Jemec, "Optical coherence tomography in dermatology," G. Ital. Dermatol.Venereol. 150(5), 603-615 (2015). 3. M. Ulrich, L. Themstrup, N. de Carvalho, M. Manfredi, C. Grana, S. Ciardo, R. Kästle, J. Holmes, R.Whitehead, G. B. Jemec, G. Pellacani, and J. Welzel, "Dynamic Optical Coherence Tomography in Dermatology," Dermatology (Basel) 232(3), 298-311 (2016). 4. G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21(7), 543-545 (1996). 5. A. M. Rollins, R. Ung-Arunyawee, A. Chak, R. C. K. Wong, K. Kobayashi, M. V. Sivak, Jr., and J. A. Izatt, "Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design," Opt. Lett. 24(19), 1358-1360 (1999). 6. M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A.Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51(4), 474-479 (2000). 7. J. Xi, A. Zhang, Z. Liu, W. Liang, L. Y. Lin, S. Yu, and X. Li, "Diffractive catheter for ultrahigh-resolution spectral-domain volumetric OCT imaging," Opt. Lett. 39(7), 2016-2019 (2014). 8. P. H. Tran, D. S. Mukai, M. Brenner, and Z. Chen, "In vivo endoscopic optical coherence tomography by use of a rotational microelectromechanical system probe," Opt. Lett. 29(11), 1236-1238 (2004). Goodnow, and C. Petersen, "Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography," Opt. Lett. 29(19), 2261-2263 (2004). 10. T.-H. Tsai, B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, C. Zhou, J. Hornegger, H.Mashimo, A. E. Cable, and J. G. Fujimoto, "Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology," Biomed. Opt. Express 4(7), 1119-11...

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“…5 Our group also reported an office-based laryngeal time-domain OCT imaging device. 6 A rigid laryngoscope served as a platform to which a second device could be attached to perform simultaneous OCT imaging. However, the scanning mechanism was too slow at a rate of ϳ1 frame per second.…”

Section: Introductionmentioning

confidence: 99%

Office-based dynamic imaging of vocal cords in awake patients with swept-source optical coherence tomography

Liu

Rubinstein

et al. 2009

J. Biomed. Opt.

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Abstract. Optical coherence tomography ͑OCT͒ is an evolving noninvasive imaging modality that has been used to image the human larynx during surgical endoscopy. The design of a long gradient index ͑GRIN͒ lens-based probe capable of capturing images of the human larynx by use of swept-source OCT during a typical office-based laryngoscopy examination is presented. In vivo OCT imaging of the human larynx is demonstrated with a rate of 40 frames per second. Dynamic vibration of the vocal folds is recorded to provide not only high-resolution cross-sectional tissue structures but also vibration parameters, such as the vibration frequency and magnitude of the vocal cords, which provides important information for clinical diagnosis and treatment, as well as fundamental research of the voice itself. Office-based OCT is a promising imaging modality to study the larynx for physicians in otolaryngology.

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Office-based optical coherence tomographic imaging of human vocal cords

Cited by 37 publications

References 7 publications

Automated working distance adjustment enables optical coherence tomography of the human larynx in awake patients

Automated working distance adjustment enables optical coherence tomography of the human larynx in awake patients

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Office-based dynamic imaging of vocal cords in awake patients with swept-source optical coherence tomography

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