Office-based salivary gland ductal irrigation in patients with chronic sialoadenitis: A preliminary study

Chen, Yen-Chun; Dang, Luong Huu; Chen, Lung Che; Chang, Chi Ching; Han, Deng; Hsu, Chia-Hsiang; Ding, Yi; Su, Cheng‐Huang; Hung, Shih‐Han

doi:10.1016/j.jfma.2020.10.004

Cited by 10 publications

(12 citation statements)

References 26 publications

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“…An alternative treatment option for chronic sialadenitis in this patient population is steroid irrigation without sialendoscopy. Three previous studies comprising a total of 69 patients with Sjogren's reported on this treatment modality, with success rates ranging from 61.5% to 64.2% [16][17][18]. For patients with RAI, one study reported an 83% success rate in 6 patients [18].…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…Three previous studies comprising a total of 69 patients with Sjogren's reported on this treatment modality, with success rates ranging from 61.5% to 64.2% [16][17][18]. For patients with RAI, one study reported an 83% success rate in 6 patients [18]. The two larger studies utilized different irrigation regimens, 2-3 months of saline irrigation and weekly steroid irrigation for 3 weeks versus monthly steroid irrigations for 4 months.…”

Section: Discussion/conclusionmentioning

confidence: 99%

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Management of Chronic Sialadenitis due to Sjogren’s Syndrome and Radioactive Iodine Therapy Using Sialendoscopy

Douglas

Wen

Thomas

et al. 2022

ORL

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Introduction: Sialendoscopy is a minimally invasive technique for the management of salivary gland disease. This work characterizes its utility for treating chronic sialadenitis due to Sjogren’s syndrome and radioactive iodine (RAI) therapy. Methods: A single-center, retrospective review of patients undergoing sialendoscopy between March 2013 and May 2019 for the treatment of chronic sialadenitis due to Sjogren’s or prior RAI therapy was performed. Results: Thirty-four patients with Sjogren’s and 25 patients who received RAI were identified, undergoing a total of 86 procedures. Median age at presentation was 53 years with mean follow-up time of 14.3 months. Seventy-two procedures were performed on the parotid gland, four on the submandibular gland, and ten on both glands. Corticosteroid injection and duct dilation were performed most commonly. Sixteen patients required repeat procedure. All patients were symptomatically improved at follow-up visit. Discussion/Conclusion: These results support the idea that sialendoscopy offers symptomatic benefit for patients with chronic sialadenitis due to Sjogren’s or RAI.

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Section: Discussion/conclusionmentioning

confidence: 99%

Section: Discussion/conclusionmentioning

confidence: 99%

Management of Chronic Sialadenitis due to Sjogren’s Syndrome and Radioactive Iodine Therapy Using Sialendoscopy

Douglas

Wen

Thomas

et al. 2022

ORL

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“… 15 In that study, patients with early-stage Sjögren syndrome showed a significantly favorable response to irrigation. Chen et al 18 also reported that over 60% of Sjögren syndrome patients showed a positive response to retroductal irrigation with corticosteroids. Sjögren syndrome primarily causes inflammation of the salivary and lacrimal glands.…”

Section: Discussionmentioning

confidence: 98%

Efficacy of corticosteroid ductal irrigation in acute salivary gland inflammation induced in a rat model

Lee

Kim

et al. 2022

Imaging Sci Dent

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Purpose This study aimed to compare the therapeutic effects of corticosteroid irrigations and normal saline irrigations in the early inflammatory state of the salivary gland. Materials and Methods Adult male Wistar rats were divided into experimental (n=6) and control (n=3) groups. Inflammation was induced in the experimental subjects on both sides of the submandibular gland with ligation. After 14 days, both sides of the glands were de-ligated and retroductal irrigation using saline (n=3) and a corticosteroid (n=3) was performed on the left sides only. The controls (n=3) were used to normalize the gland state for the effects of diet and aging. Magnetic resonance imaging was performed to confirm inflammation and post-irrigation gland recovery by measuring relative signal intensity (SI). The glands were excised for histological examination. Results All experimental animals showed inflamed glands with increased SI and subsequent recovery of the gland with decreased SI to varying degrees. The SI of the controls showed no significant changes during the overall period. The mean SI change of the irrigated gland was higher than that of the non-irrigated side, without a significant difference. The corticosteroid-irrigated glands showed a greater change in SI than that of the saline-irrigated glands. Histology revealed that inflammation was not observed in most of the irrigated glands, while mild to moderate quantities inflammatory cells were found in non-irrigated glands. Conclusion Corticosteroid irrigation mitigated the early stages of salivary gland inflammation more effectively than normal saline.

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“…Sialoscintigraphy protocols were described in our previous study. 17 , 18 In brief, after fasting for more than 2 h before the exam, subjects received intravenous injection of 259 MBq (7 mCi) of 99mTc‐pertechnetate followed with sequential image acquirement every 30 s. 19–20 min after the injection, sialogauge (20 ml of lemon juice) was administered orally.…”

Section: Methodsmentioning

confidence: 99%

Impaired spontaneous secretion as a potential factor in the development of sialolithiasis in the submandibular gland: A preliminary sialoscintigraphic study

Chen

Dang

Chang

et al. 2022

Laryngoscope Investig Oto

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Objectives The development of sialolithiasis is commonly related to local factors, such as the retrograde migration of foods, bacteria, or foreign bodies from the oral cavity. The association of sialolithiasis and saliva stasis resulting from decreased spontaneous secretion remains largely unexplored. The current study investigated the potential role of impaired spontaneous secretion in association with the formation of submandibular gland calculi. Study Design A retrospective cohort study. Methods Between September 2016 and December 2017, 11 patients with unilateral submandibular gland sialolithiasis confirmed with sialendoscopy were assigned to the experimental group. Another 35 patients clinically diagnosed with parotid obstructive sialadenitis were assigned as the control group. The slope changes of the isotope count curve of the unaffected submandibular gland in the experimental group and the bilateral submandibular glands in the control group were calculated and compared to estimate the spontaneous secretion differences. The degree of spontaneous secretion was defined as the slope changes in the steady ascending stage of the scintigraphic exam. Results The slope decline (degree of spontaneous secretion) on the unaffected side in patients with single‐gland submandibular obstructive sialadenitis was significantly lower than that in the control individuals ( p = .002). In contrast, the between‐group comparison in the unaffected parotid glands revealed no difference in the slope decline. Conclusion The spontaneous secretion of the submandibular gland in patients with submandibular sialolithiasis was decreased compared to that in patients without submandibular sialolithiasis. This phenomenon might be associated with the development of sialolithiasis. Level of Evidence 3.

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Office-based salivary gland ductal irrigation in patients with chronic sialoadenitis: A preliminary study

Cited by 10 publications

References 26 publications

Management of Chronic Sialadenitis due to Sjogren’s Syndrome and Radioactive Iodine Therapy Using Sialendoscopy

Management of Chronic Sialadenitis due to Sjogren’s Syndrome and Radioactive Iodine Therapy Using Sialendoscopy

Efficacy of corticosteroid ductal irrigation in acute salivary gland inflammation induced in a rat model

Impaired spontaneous secretion as a potential factor in the development of sialolithiasis in the submandibular gland: A preliminary sialoscintigraphic study

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