Official Positions of the International Society for Clinical Densitometry

Leib, Edward S.; Lewiecki, E. Michael; Binkley, Neil; Hamdy, Ronald C.

doi:10.1385/jcd:7:1:1

Cited by 282 publications

(94 citation statements)

References 11 publications

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“…T-score values between −1.5 and −2.5 were considered as osteopenia, while values lower than −2.5 were considered as osteoporosis, according to the standard World Health Organization (WHO) criteria for postmenopausal women [13]. We used the same criteria for the definition of osteoporosis in males, as the International Society of Clinical Densitometry (2004) has applied the same bone mineral density (BMD) criteria for the definition of osteoporosis in males and recommended that a male database may be used for male patients and a Caucasian database for both Caucasian and nonCaucasians [14,15]. Moreover, BMD T scores were derived by comparison to BMD values of normal persons from the Greek population [16].…”

Section: Methodsmentioning

confidence: 99%

Increased bone resorption is implicated in the pathogenesis of bone loss in hemophiliacs: correlations with hemophilic arthropathy and HIV infection

et al. 2009

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International audienceOsteoporosis has been recently recognized as a severe comorbidity factor in hemophilia. However, its pathogenesis is still obscure. We evaluated the incidence of osteoporosis in 90 hemophilia patients and investigated possible correlations with clinical and laboratory data. Out of the 90 patients, 80 (89%) had severe hemophilia, and 35 (38.9%) were human immunodeficiency virus (HIV)-positive. Hemophilic arthropahty was assessed using World Federation of Hemophilia clinical score and Petterson radiological score. Bone mineral density of the lumbar spine (LS) and femoral neck (FN) were measured using dual-energy X-ray absortiometry. Bone turnover was evaluated by the measurement of: (1) bone resorption markers [N-terminal cross-linking telopeptide of collagen type I (NTX), C-terminal cross-linking telopeptide of collagen type I (CTX), and tartrate-resistant acid phosphatase isoform-5b (TRACP-5b)], (2) bone formation markers [bone-alkaline phosphatase (bALP) and osteocalcin], and (3) osteoclast stimulators (receptor activator of nuclear factor-κB ligand, osteoprotegerin, and tumor necrosis factor-alpha). Osteopenia or osteoporosis was observed in 86% and 65% of the patients in FN and LS, respectively. Osteoporosis was more common among HIV-positive patients in both FN (65.3% vs 41.6%; = 0.007) and LS (17.86% vs 5.41%, = 0.004). The severity of osteoporosis in FN correlated with the patients' total clinical and radiological score ( = 0.001). Hemophilia patients showed increased osteoclastic activity (significant increase of TRACP-5b, NTX, and CTX), which was not accompanied by a comparable increased bone formation (reduced osteocalcin and borderline increase of bALP). In multivariate analysis, HIV infection ( = 0.05) and total clinical score ( = 0.001) were independent risk factors for osteoporosis development. We conclude that there is a high prevalence of osteoporosis among hemophiliacs, which is related to the severity of arthropathy and is enhanced by HIV infection. We report for the first time a high bone resorption that seems not to be balanced by a comparable bone formation

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Section: Methodsmentioning

confidence: 99%

Increased bone resorption is implicated in the pathogenesis of bone loss in hemophiliacs: correlations with hemophilic arthropathy and HIV infection

et al. 2009

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“…However, this sample included a large number of Hutterites from the University of South Dakota studies, a group living in socially isolated farming communities and known to have high bone density (Wey et al 2009). Of note, only children of European ancestry were included in these curves in accordance with the official positions of the International Society for Clinical Densitometry at that time (Leib et al 2004).…”

Section: Development Of Dxa Reference Datamentioning

confidence: 99%

Human biology at the interface of paediatrics: Measuring bone mineral accretion during childhood

Zemel

2012

Annals of Human Biology

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“…5,6 However, many experts, including the International Society for Clinical Densitometry, recommend using the lowest central DXA T score of posteroanterior lumbar spine, femoral neck, or total hip (or the 33% distal radius of the nondominant forearm, if measured) to make the diagnosis. 7 Dual-energy x-ray absorptiometric measurements of BMD at other sites (including the trochanter, Ward triangle, lateral lumbar spine, other forearm regions, heel, or total body) or with other technologies (calcaneal ultrasonography, peripheral DXA, quantitative computed tomography, single-or dual-photon radionuclide absorptiometry, or magnetic resonance imaging) may be useful for assessing risk of fracture, but they are not recommended for use in diagnosing osteoporosis. 6,7 If DXA measurements at different sites are considerably disparate, most clinicians would use the lowest BMD measurement.…”

Section: Diagnosis Screening Prevention and Treatment Of Osteoporosismentioning

confidence: 99%

“…7 Dual-energy x-ray absorptiometric measurements of BMD at other sites (including the trochanter, Ward triangle, lateral lumbar spine, other forearm regions, heel, or total body) or with other technologies (calcaneal ultrasonography, peripheral DXA, quantitative computed tomography, single-or dual-photon radionuclide absorptiometry, or magnetic resonance imaging) may be useful for assessing risk of fracture, but they are not recommended for use in diagnosing osteoporosis. 6,7 If DXA measurements at different sites are considerably disparate, most clinicians would use the lowest BMD measurement. Dual-energy x-ray absorptiometric measurement of bone density is noninvasive, accurate, reproducible, and predictive of short-and long-term fracture risk.…”

Section: Diagnosis Screening Prevention and Treatment Of Osteoporosismentioning

confidence: 99%

Diagnosis, Screening, Prevention, and Treatment of Osteoporosis

Mauck¹,

Clarke

2006

Mayo Clinic Proceedings

114

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Osteoporosis is the most common bone disease in humans and affects both men and women. The clinical and public health implications of the disease are substantial because of the mortality, morbidity, and cost of medical care associated with osteoporotic fractures. Osteoporosis is diagnosed on the basis of a low-impact or fragility fracture or low bone mineral density, which was best assessed by central dual-energy x-ray absorptiometry. Both nonpharmacological therapy (calcium and vitamin D supplementation, weight-bearing exercise, and fall prevention) and pharmacological treatments (antiresorptive and anabolic agents) may be helpful in the prevention and treatment of osteoporosis. Therefore, clinicians need to be vigilant in instituting primary prevention measures for those at high risk for osteoporosis and in instituting treatment for patients diagnosed as having the disease either by screening or a history of fracture. This article provides an overview of the diagnosis, screening, prevention, and treatment of osteoporosis.

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Official Positions of the International Society for Clinical Densitometry

Cited by 282 publications

References 11 publications

Increased bone resorption is implicated in the pathogenesis of bone loss in hemophiliacs: correlations with hemophilic arthropathy and HIV infection

Increased bone resorption is implicated in the pathogenesis of bone loss in hemophiliacs: correlations with hemophilic arthropathy and HIV infection

Human biology at the interface of paediatrics: Measuring bone mineral accretion during childhood

Diagnosis, Screening, Prevention, and Treatment of Osteoporosis

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