OGG1 Ser326Cys Polymorphism and Susceptibility to Esophageal Cancer in Low and High At-Risk Populations of Northern India

Upadhyay, Rohit; Malik, None Manzoor Ahmed; Zargar, Showkat Ali; Mittal, Balraj

doi:10.1007/s12029-009-9124-5

Cited by 17 publications

(10 citation statements)

References 32 publications

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“…However, studies by Guo et al [18] and Wang et al [17] in Chinese population included only ESCC histology patients, but still showed significant association. The incongruity with Chinese reports from ours may be due population/ethnic variations which are also evident in our previous studies [28,29]. Similar to our report, a study in head and neck cancer by Liu et al [12] in Caucasian population showed combined risk genotypes of common SNPs in pre-miRNAs were associated significantly with increased risk of SCC of head and neck cancer.…”

Section: E16supporting

confidence: 64%

Evaluation of common genetic variants in pre‐microRNA in susceptibility and prognosis of esophageal cancer

Umar

Upadhyay

Prakash

et al. 2012

Molecular Carcinogenesis

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Genetic variants in micro-RNAs (miRNA) have been shown to affect progression, diagnosis, and prognosis of various malignancies; however, their role in esophageal squamous cell carcinoma (ESCC) susceptibility is controversial. Therefore, we aimed to determine role of common genetic variants in cancer related pre-miRNA in susceptibility and survival outcome of north Indian ESCC patients. We genotyped four common polymorphisms in pre-miRNA: mir-196a-2C>T, mir-146aG>C, mir-499T>C, and mir-423C>A in 289 incident ESCC cases (including 153 follow-up cases) and 309 controls using PCR/PCR RFLP-based methods. Binary logistic regression was applied for risk estimation, while Kaplan-Meier and Cox Regression tests were performed for survival analysis. We observed that none of the pre-miRNA genetic variants were associated with ESCC or its clinical phenotypes independently, however, combined risk genotypes of four pre-miRNA polymorphisms increased risk of ESCC in dose-response manner (Ptrend = 0.011). Specifically, patients with 2-4 risk genotypes of pre-miRNA polymorphisms had 1.4-fold higher risk of ESCC compared to patients with 0-1 risk genotypes (OR = 1.43, 95% CI = 1.02-1.09, P-value = 0.037). The risk was more pronounced in ESCC cases with upper-third esophageal tumors. Moreover, cumulative but not independent effect of risk genotypes of pre-miRNA polymorphisms was observed on survival outcome of ESCC patients. Cases with 2-4 risk genotypes had significantly lower median survival (11.60 vs. 30.2 months) and 2.3-fold greater hazard of death compared to patients with 0-1 risk genotypes. In conclusion, the four studied common pre-miRNA polymorphisms cumulatively affect susceptibility and survival of ESCC patients in north Indian population. © 2012 Wiley Periodicals, Inc.

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Section: E16supporting

confidence: 64%

Evaluation of common genetic variants in pre‐microRNA in susceptibility and prognosis of esophageal cancer

Umar

Upadhyay

Prakash

et al. 2012

Molecular Carcinogenesis

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“…In present study, we did not find any association of CASP8 −652 6N del polymorphism with ESSC or its clinical characteristics in northern Indian population. This discrepancy may be related to vast difference in incidence of EC in Chinese and northern Indian populations ensuing difference in genetic make‐up and thus in genetic association of EC between two populations as previously reported 33, 34. Similar to our finding, Haiman et al 35 also did not find any association of CASP8 −652 6N del variant with breast, colorectal, and prostrate cancers in multiple populations of various ancestries, contradictory to prior report by Sun et al 14 Likewise, several other reports also failed to replicate purported association with different cancers supporting our hypothesis of population‐specific nature of association 18, 20, 36.…”

Section: Discussionmentioning

confidence: 86%

CASP8 −652 6N del and CASP8 IVS12‐19G>A gene polymorphisms and susceptibility/prognosis of ESCC: A case control study in northern Indian population

Umar

Upadhyay

Kumar

et al. 2011

Journal of Surgical Oncology

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“…In a preliminary search, we identified 58 research articles related to OGG1 Ser326Cys polymorphism and the risk of head and neck, oral, pancreatic, gallbladder, colorectal and gastric cancers. Among all the articles identified, only 31 were subjected to further examination out of which only 17 (Kumar et al 2011 ; Canbay et al 2011 ; Srivastava et al 2009 ; Gorgens et al 2007 ; Laantri et al 2011 ; Sameer et al 2012 ; Sliwinski et al 2011 ; Li et al 2013 ; Upadhyay et al 2010 ; Canbay et al 2010 ; Palli et al 2010 ; Engin et al 2011 ; Curtin et al 2009 ; Przybylowska et al 2013 ; Pardini et al 2008 ; Li et al 2009 ; Srivastava et al 2010 ) were found to meet the inclusion criteria (Table 1 ). Many of them were removed from the study due to lack of detailed information of all the genotypes and also due to non accordance of the controls with the Hardy–Weinberg equilibrium.…”

Section: Resultsmentioning

confidence: 99%

Association between OGG1 Ser326Cys polymorphism and risk of upper aero-digestive tract and gastrointestinal cancers: a meta-analysis

et al. 2016

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Cancers of the upper aero-digestive and gastrointestinal tract are one of the major causes of mortality around the world. DNA repair genes play a vital role in preventing carcinogenesis by maintaining genomic integrity. Polymorphisms in the nucleotide sequence of DNA repair genes are often reported to be associated with an increased risk for different cancers. The OGG1 gene encodes the enzyme 8-oxoguanine DNA glycosylase which removes oxidatively damaged bases of DNA. Several studies report that the OGG1 Ser326Cys polymorphism increases the risk for cancers of the upper aero-digestive and gastrointestinal tract. However, other studies provide evidence that such an association does not exist. A meta-analysis to assess the role of OGG1 Ser326Cys polymorphism in the cancers of the upper aero-digestive and gastrointestinal tract was therefore undertaken in order to resolve this ambiguity. Seventeen studies were recruited for this meta-analysis after screening 58 articles with a total of 5533 cases and 6834 controls for which the odds ratio with 95 % confidence interval was calculated. Begg’s funnel test and Egger’s test were performed for calculating publication bias. Our study reveals an association between OGG1 Ser326Cys polymorphism and cancer susceptibility of the upper aero-digestive and gastrointestinal tract (CG + GG vs CC; odds ratio, OR 1.22; 95 % CI 1.05–1.41; GG vs CG + CC; OR 1.36; 95 % CI 1.09–1.70; GG vs CC; OR 1.46; 95 % CI 1.12–1.92). Subgroup analysis based on cancer types and ethnicity also revealed the association of OGG1 Ser326Cys polymorphism to the risk for upper aero-digestive and gastrointestinal tract cancers among both the Asian and the Caucasian populations. No risk was however observed for smoking habits and OGG1 Ser326Cys polymorphism. In conclusion, OGG1 Ser326Cys polymorphism may be associated with the increased risk for aero-digestive tract and gastro-intestinal cancers in both Asian and Caucasian populations.

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OGG1 Ser326Cys Polymorphism and Susceptibility to Esophageal Cancer in Low and High At-Risk Populations of Northern India

Abstract: OGG1 Ser326Cys polymorphism does not have a role in determining susceptibility to esophageal cancer either in high or in low at-risk populations of Northern India.

Cited by 17 publications

References 32 publications

Evaluation of common genetic variants in pre‐microRNA in susceptibility and prognosis of esophageal cancer

Evaluation of common genetic variants in pre‐microRNA in susceptibility and prognosis of esophageal cancer

CASP8 −652 6N del and CASP8 IVS12‐19G>A gene polymorphisms and susceptibility/prognosis of ESCC: A case control study in northern Indian population

Association between OGG1 Ser326Cys polymorphism and risk of upper aero-digestive tract and gastrointestinal cancers: a meta-analysis

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