The study aims to examine in depth the perceptions of teachers and administrators about the organizational change process of a deep-rooted high school through a university collaboration in Turkey. We utilized a case study within the realm of qualitative research. We gathered the data via semi-structured interviews, and we used content analysis in the analysis. As a result of the analysis of the findings, four themes were reached which are change as perceptions, awareness, process, and effect on change. The views of participants revealed that there had been a change in factors that increase the effectiveness of the educational environment such as school climate, student profile, parent/environmental involvement, and improvement of physical equipment. Based on some positive results, it was suggested that such cooperation practices should be disseminated, independent accreditation institutions should be consulted at the change stages to increase success, and initiatives should be taken to increase the competencies of key people who will make change effective.