Oh My Glucosides! Occult Sources in Medical Products

Schlarbaum, Jamie P.; Liou, Yujie Linda; Kimyon, Rebecca S.; Olson, Cynthia L.; Warshaw, Erin M.

doi:10.1097/der.0000000000000476

Cited by 6 publications

(6 citation statements)

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“…Alkyl glucosides increase foaming in products and are important PCP allergens 60 . Glucosides were named the 2017 ACDS Contact Allergen of the Year 9,61 . Five glucosides were identified in 25% or more MFMs; cetearyl glucoside was the most common (15.4%, data not shown).…”

Section: Discussionmentioning

confidence: 99%

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Men's Facial Moisturizers in the Metrosexual Era

Schlarbaum

Warshaw

2021

Dermatitis

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BackgroundManufacturers are increasingly branding personal care products (PCPs) specifically for men.ObjectiveThe aim of the study was to characterize ingredients and claims of facial moisturizers marketed to men.MethodsMen's facial moisturizers from 7 different online retailers were identified in June–September 2018. Ingredients were grouped and identified per the Ingredient Database of the Personal Care Products Council. Potential allergens were identified using the 2017 American Contact Dermatitis Society (ACDS) Core Allergen Series and 2017–2018 North American Contact Dermatitis Group Screening Series.ResultsSixty-five men's facial moisturizers were identified with a total of 1930 ingredients. On average, there were 12 ACDS Core and 9 North American Contact Dermatitis Group Screening allergens per product. A total of 70.8% of products contained between 6 and 15 ACDS Core allergens. The most notable allergens were fragrances (present in 98.5% of products), propylene glycol/derivatives (32.3%), parabens (29.2%), and alkyl glucosides (26.2%). Interestingly, less than 10% of products contained the most common allergenic preservatives in PCPs: formaldehyde releasers and methylisothiazolinone.ConclusionsMen's facial moisturizers commonly contain fragrances, emulsifiers, and glucosides but relatively few allergenic preservatives. This may reflect changes in modern PCP preservation. These findings are important for modern dermatologists to be aware, especially in a new era of male skincare.

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Section: Discussionmentioning

confidence: 99%

“…60 Glucosides were named the 2017 ACDS Contact Allergen of the Year. 9,61 Five glucosides were identified in 25% or more MFMs; cetearyl glucoside was the most common (15.4%, data not shown). The studies by Xu et al 16 and Chou et al 23 did not report glucosides.…”

Section: Surfactantsmentioning

confidence: 90%

Men's Facial Moisturizers in the Metrosexual Era

Schlarbaum

Warshaw

2021

Dermatitis

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“…Allergenic ingredients less commonly identified in this study included sorbic acid derivatives, alkyl glucosides, phenoxyethanol, parabens, benzophonone-4, and cocamidopropyl betaine. Although these ingredients have not been associated with contact allergy to hand sanitizers at present, some of these allergens have been responsible for ACD reactions to other medical products with significant clinical relevance 11,34,35 . Patients and HCWs with specific sensitivities can practice allergen avoidance of these components using the product list from Table 3.…”

Section: Discussionmentioning

confidence: 99%

Allergenic Ingredients in Health Care Hand Sanitizers in the United States

2021

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Background: Health care workers with occupational contact dermatitis often attribute their symptoms to frequent use of alcohol-based hand sanitizers. However, ingredient lists are difficult to obtain, and safe alternatives typically must accommodate brands utilized by a particular hospital system.Objective: The aims of this study were to investigate allergenic ingredients present within health care hand sanitizers and to provide a comprehensive product list to assist with allergen avoidance.Methods: Five major hospitals in Minnesota and 20 hospitals across the United States were called to obtain a product list. The National Library of Medicine's DailyMed Web site was searched to retrieve ingredients. Ingredients were compared with the American Contact Dermatitis Society 2017 Core Allergen Series and cross-reactors.Results: The most common brands included Purell, Ecolab, DebMed, and Avagard. Active ingredients consisted of ethyl alcohol (85.0%), benzalkonium chloride (8.8%), or isopropyl alcohol (2.5%). Top 5 allergens included tocopherol (51.3%), fragrance (40.0%), propylene glycol (27.5%), benzoates (25.0%), and cetyl stearyl alcohol (12.5%). Four sanitizers were free of all American Contact Dermatitis Society allergens; 15 products contained only tocopherol or propylene glycol as allergens.Conclusions: We identified 19 low-allergen hand sanitizers within the most common brands utilized by US hospital systems. This product list will be useful for patients and health care workers seeking allergen avoidance.

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“…Alkylglucoside sind in Kosmetika und anderen Produkten weit verbreitet; z. B. als Bestandteil einer Schaum-Wundauflage, die bei einer 70-jährigen Belgierin eine ACD verursachte [218], oder verschiedener Wundpflege- und Operationsprodukte, die bei 2 US-Patienten eine ACD auslösten [219]. Laurylglucosid als ein solches Derivat hat sich mit einer Quote von 3 von 264 französischen Patienten mit Augenlid-Dermatitis als aktuell relevantes Kontaktallergen erwiesen [220].…”

Section: Ergebnisseunclassified

Kontaktallergien – Neu aufkommende Allergene und Auswirkungen für das Gesundheitswesen

Uter¹,

Werfel

Lepoittevin

et al. 2021

Kompass Dermatol

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Kontaktallergie (Sensibilisierung) und daraus resultierende allergische Kontaktdermatitis (ACD) sind von erheblicher Tragweite aus Sicht des Gesundheitswesens. Für die vorliegende Übersichtsarbeit hierzu wurden alle passenden Artikel aus dem Zeitraum 2018–2019 per systematischer Suche in Medline und Web of Science<sup>TM</sup> ermittelt; außerdem wurden alle verfügbaren Ausgaben der Fachzeitschriften „Contact Dermatitis“ und „Dermatitis“ manuell durchsucht und so eine frühere, ähnliche Übersichtsarbeit fortgeschrieben und neu fokussiert. Neue Allergene ebenso wie bekannte Allergene, die in neuem Expositionskontext gefunden wurden oder deren Bedeutung in sonstiger Hinsicht neu bewertet wurde, werden in Abschnitten nach Substanzklasse gegliedert beschrieben (z. B. Metalle, Konservierungsmittel, Duftstoffe). Als gemeinsames Ergebnis zahlreicher Untersuchungen fällt sowohl ein Mangel an Informationen über die Produktzusammensetzung auf, z. B. in Bezug auf ein neu beschriebenes Allergen in Leinenturnschuhen (Dimethylthiocarbamylbenzothiazolsulfid), als auch vor allem die mangelnde Kooperativität von Herstellern von Blutzuckermessgeräten bzw. Insulinpumpen. Zu den letztgenannten Geräten hat eine internationale Zusammenarbeit zwischen Dermatologen und Chemikern gezeigt, dass sie bei zahlreichen Diabetikern schwere ACD verursachen, indem sie Isobornylacrylat bzw. N,N’-Dimethylacrylamid freisetzen. Eine verbesserte und vollständige Deklaration der Inhaltsstoffe für Produkte alle Art – und nicht nur, wie wir es derzeit in Europa haben, bei Kosmetika (abgesehen von der vollständigen Auflistung der Duftstoffe) – muss auf die legislative Agenda gesetzt werden.

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Oh My Glucosides! Occult Sources in Medical Products

Cited by 6 publications

References 4 publications

Men's Facial Moisturizers in the Metrosexual Era

Men's Facial Moisturizers in the Metrosexual Era

Allergenic Ingredients in Health Care Hand Sanitizers in the United States

Kontaktallergien – Neu aufkommende Allergene und Auswirkungen für das Gesundheitswesen

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