Oh no, Notch again!

Frisén, Jonas; Lendahl, Urban

doi:10.1002/1521-1878(200101)23:1<3::aid-bies1001>3.0.co;2-f

Cited by 27 publications

(6 citation statements)

References 39 publications

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“…Additionally, Jagged1 might activate Notch when receptor‐ligand engagement occurs between neighboring cells. Such cis ‐ and trans ‐dependent differences have been demonstrated for the interaction of Notch with another ligand, Delta, on developing neuronal cells (reviewed in Artavanis‐Tsakonas et al, 1999; Frisen and Lendahl, 2001). Whether analogous multifaceted signaling pathways can occur between Notch1 and Jagged1 in the pulmonary vasculature has yet to be determined.…”

Section: Discussionmentioning

confidence: 91%

“…Second, in addition to acting as a “gatekeeper” and restricting the number of cells responding to various inductive cues, the Notch family might also function later in the stabilization and maintenance of a matured system. In neuronal development, for example, Notch signaling functions beyond initial differentiation of glial cells to influence the length and organization of established neuronal processes through successive “pruning” (reviewed in Frisen and Lendahl, 2001). The acquisition we have observed of Notch1 and Jagged1 by maturing vascular structures of the lung during embryonic development, and their persistence in the adult animal, may similarly represent a role in vascular homeostasis.…”

Section: Discussionmentioning

confidence: 99%

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Notch1 and Jagged1 expression by the developing pulmonary vasculature

Taichman

Loomes

Schachtner

et al. 2002

Developmental Dynamics

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The molecular mechanisms of pulmonary vascular development are poorly understood. Cell-specific developmental pathways are influenced by cell-cell signaling. Notch signaling molecules are highly conserved receptors active in many cell-fate determination systems. Recent observations of Notch molecules and a Notch ligand, Jagged1, suggest their importance in vascular morphogenesis, and particularly pulmonary vascular development. We performed a systematic evaluation of Notch1/Jagged1 gene and protein expression in the developing mouse lung from embryonic day 11 until adulthood by using quantitative PCR, immunofluorescence, and electron microscopic analysis. mRNA transcripts for Notch1-4 and Jagged1 increased progressively from early to later lung development, accompanied by a simultaneous rise in endothelial cell-specific gene expression, a pattern not seen in other organs. Notch1 mRNA was identified on both epithelial and mesenchymal structures of the embryonic lung. Immunofluorescence staining revealed the progressive acquisition of Notch1 and Jagged1 proteins by the emerging endothelium. Notch1 and Jagged1 were seen initially on well-formed, larger vessels within the embryonic lung bud and progressively on finer vascular networks. Each was also expressed on surrounding nonvascular structures. The localization of Notch1 and Jagged1 on endothelial cell surface membranes within the alveolar microvasculature was confirmed by immuno-electron microscopy. These temporal and spatial patterns in Notch1/Jagged1 gene and protein expression suggest multiple potential paths of cell-cell signaling during lung development and vascular morphogenesis.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Notch1 and Jagged1 expression by the developing pulmonary vasculature

Taichman

Loomes

Schachtner

et al. 2002

Developmental Dynamics

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“…The expression of pro‐gliogenic transcription factors may be regulated through cell surface receptors such as notch25. It has been shown that jagged‐1 (a notch ligand) signalling by neurones suppresses the oligodendrocyte phenotype26.…”

Section: An Overview Of Brain Development During Embryogenesismentioning

confidence: 99%

Neural stem cells

Kennea

Mehmet

2002

The Journal of Pathology

102

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Neural stem cells (NSCs) have the ability to self-renew, and are capable of differentiating into neurones, astrocytes and oligodendrocytes. Such cells have been isolated from the developing brain and more recently from the adult central nervous system. This review aims to provide an overview of the current research in this evolving area. There is now increasing knowledge of the factors controlling the division and differentiation of NSCs during normal brain development. In addition, the cues for differentiation in vitro, and the possibility of transdifferentiation are reviewed. The discovery of these cells in the adult brain has encouraged research into their role during neurogenesis in the normal mature brain and after injury. Lastly other sources of neural precursors are discussed, and the potential for stem cells to be used in cell replacement therapy for brain injury or degenerative brain diseases with a particular emphasis on cerebral ischaemia and Parkinson's disease.

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“…Notch is also involved in several other neural lineages where it controls glial vs. neuronal development [84,85,86,87,88,89]. A Notch/Delta/Numb system is similarly used in many asymmetric cell divisions that occur during neural development in Drosophila [90,91,92,93] and Notch has been shown to control neuronal vs. glial fate choices in some of these lineages [94,95].…”

Section: Vervoort and Ledent: Neural Basic Helix Loop -Helix Loop Promentioning

confidence: 99%

The Evolution of the Neural Basic Helix-Loop-Helix Proteins

Vervoort

Ledent

2001

The Scientific World JOURNAL

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Basic Helix-Loop-Helix (bHLH) transcription factors control various aspects of the formation of the nervous system in the metazoans. In Drosophila, some bHLH (such as the achaete-scute, atonal, and amos genes) act as proneural genes, directing ectodermal cells toward a neural fate. Their vertebrate orthologs, however, probably do not assume such a neural determination function, but rather control the decision made by neural precursors to generate neurons and not glial cells, as well as the progression of neuronal precursors toward differentiation into mature neurons. The proneural function of Drosophila bHLH genes may be an innovation that occurs in the evolutive lineage that leads to arthropods. In addition, although neural bHLH appear to be involved in the specification of neuronal identities, they probably do not confer by themselves neuronal type-specific properties to the cells. Rather, neural bHLH allow neural cells to correctly interpret specification and positional cues provided by other factors. Although bHLH genes are often expressed in complementary subsets of neural cells and/or expressed sequentially in those cells, the coding regions of the various neural bHLH appear largely interchangeable. We propose that the specific expression patterns have been acquired, following gene duplications, by subfunctional-ization, i.e., the partitioning of ancestral expression patterns among the duplicates and, by extension, we propose that subfunctionalization is a key process to understand the evolution of neural bHLH genes.t KEY WORDS: basic Helix-loop-Helix (bHLH), nervous system, neurogenesis, evolution, neural specification, neural determination BHLH PROTEINS IN NERVOUS SYSTEM DEVELOPMENTProteins that contain a basic Helix-Loop-Helix (bHLH) domain are known in most eukaryotic clades. The bHLH domain is approximately 60 amino acids long and comprises a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH) [1]. The HLH domain promotes dimerization, allowing the formation of homo-or heterodimeric complexes between different family members [1]. The two basic domains brought together through dimerization bind specific DNA

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Oh no, Notch again!

Cited by 27 publications

References 39 publications

Notch1 and Jagged1 expression by the developing pulmonary vasculature

Notch1 and Jagged1 expression by the developing pulmonary vasculature

Neural stem cells

The Evolution of the Neural Basic Helix-Loop-Helix Proteins

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