Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm

Gao, Can; Li, Wei; Chen, Jie; Xu, Xue Jun; Qiang, Zhi

doi:10.1038/sj.cr.7290148

Cited by 14 publications

(11 citation statements)

References 27 publications

(42 reference statements)

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“…(1999a) reported CPP for ketamine (1, 3, 10 mg/kg ip) and dizocilpine (0.1, 0.2 mg/kg ip). Gao et al . (2003) also found that ketamine (10 mg/kg ip) produced a significant CPP, and a ketamine‐induced CPP (at 3 and 10 mg/kg ip, but not 1 mg/kg ip) was also reported by Suzuki et al .…”

Section: Studies Using Systemic Drug Treatmentsmentioning

confidence: 99%

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REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

2007

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Conditioned place preference (CPP) continues to be one of the most popular models to study the motivational effects of drugs and non-drug treatments in experimental animals. This is obvious from a steady year-to-year increase in the number of publications reporting the use this model. Since the compilation of the preceding review in 1998, more than 1000 new studies using place conditioning have been published, and the aim of the present review is to provide an overview of these recent publications. There are a number of trends and developments that are obvious in the literature of the last decade. First, as more and more knockout and transgenic animals become available, place conditioning is increasingly used to assess the motivational effects of drugs or non-drug rewards in genetically modified animals. Second, there is a still small but growing literature on the use of place conditioning to study the motivational aspects of pain, a field of pre-clinical research that has so far received little attention, because of the lack of appropriate animal models. Third, place conditioning continues to be widely used to study tolerance and sensitization to the rewarding effects of drugs induced by pre-treatment regimens. Fourth, extinction/reinstatement procedures in place conditioning are becoming increasingly popular. This interesting approach is thought to model certain aspects of relapse to addictive behavior and has previously almost exclusively been studied in drug self-administration paradigms. It has now also become established in the place conditioning literature and provides an additional and technically easy approach to this important phenomenon. The enormous number of studies to be covered in this review prevented in-depth discussion of many methodological, pharmacological or neurobiological aspects; to a large extent, the presentation of data had to be limited to a short and condensed summary of the most relevant findings.

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Section: Studies Using Systemic Drug Treatmentsmentioning

confidence: 99%

“…The development of CPP induced by morphine (10 mg/kg sc) and of two stereoisomers of ohmefentanyl, F9202 (18 µg/kg sc) and F9204 (2.5 µg/kg sc), was suppressed by ketamine (10 mg/kg ip) (Gao et al . 2003).…”

Section: Studies Using Systemic Drug Treatmentsmentioning

confidence: 99%

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

2007

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“…They are accompanied by alterations in neural plasticity at glutamate synapses. CREB, a transcription factor in particular has been implicated in opiates addiction (Nestler, 2001) and CPP (Gao et al, 2003). This result suggests that CREB may play an important role in the development of morphine-induced CPP.…”

Section: Introductionmentioning

confidence: 54%

“…Furthermore, we have previously reported that c-fos expression was increased in the parietal cortex, piriform cortex, striatum, nucleus accumbens, and hippocampus of the mouse brain, which produced morphine-induced CPP (Lee et al, 2003). A transcription factor, CREB, in particular has been implicated in opiates addiction (Nestler, 2001) and CPP (Gao et al, 2003) because its activation was a consequence of upregulation of the cAMP pathway, one of the well established adaptations to drug abuse (Hyman, 1996).…”

Section: Discussionmentioning

confidence: 99%

Involvement of pCREB Expression in Inhibitory Effects of Coptis japonica on Morphine-induced Psychological Dependence

Kwon¹,

Ha²,

Lee³

et al. 2008

Biomolecules and Therapeutics

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− Morphine is a potent analgesic with significant abuse potential, because of drug craving and psychological dependence. It is reported that repeated treatment of morphine can produce conditioned place preference (CPP) showing a reinforcing effect in mice. Previously, we have reported the inhibitory effect of the methanolic extract of Coptis japonica (MCJ) on morphine-induced CPP in mice. The present study was employed whether p-CREB expression is involved in the inhibitory effect of MCJ on the morphine-induced CPP in the mouse hippocampus. Repeated administration of MCJ 100 mg/kg inhibited morphine-induced CPP. Expression of p-CREB was increased in the dentate gyrus of the hippocampus that had undergone morphineinduced CPP. This increase of expression was significantly inhibited by administration of MCJ 100 mg/kg, compared to the morphine control group. Taken together, these results suggest that MCJ inhibits morphine-induced CPP through the regulation of p-CREB expression in the mouse dentate gyrus of the hippocampus.

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“…It has been previously reported that ketamine suppresses not only the morphine-induced phosphorylation of CREB, but also the residue preference (10). A sub-anaesthetic dose of…”

Section: Introductionmentioning

confidence: 95%

Effects of intravenous anesthetics on the phosphorylation of cAMP response element‑binding protein in hippocampal slices of adult mice

et al. 2018

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cAMP response‑element binding protein (CREB) functions in hippocampal synaptic plasticity and memory formation. However, it remains unknown whether intravenous anesthetics modulate CREB. The present study aimed to examine the effects of intravenous anesthetics on CREB phosphorylation in the mouse hippocampus. CREB phosphorylation was examined in hippocampal slices with and without pharmacological or intravenous anesthetics via immunoblotting. In a dose‑response experiment, the concentrations of intravenous anesthetics ranged from 10‑9 to 10‑4 mol/l for 1 h. For the time‑response experiment, these slices were incubated with 5x10‑6 mol/l of propofol for 0, 1, 2, 5, 7, 9, 12, 15, 30 and 60 min. In order to examine whether CREB phosphorylation could be recovered following washing out the propofol, the slices were incubated in plain artificial cerebrospinal fluid at different time durations following 5 min incubation with propofol. Propofol, etomidate, ketamine and midazolam inhibited CREB phosphorylation (P<0.05) in a time‑ and dose‑dependent manner. This inhibition was reversible following the removal of propofol, and was rescued by CREB phosphorylation (P<0.05). The decrease in CREB phosphorylation revealed additive effects with 100 µM of chelerythrine and 20 µM of PD‑98059, and the etomidate‑induced decrease in CREB phosphorylation was blocked by 1 mM of NMDA. However, 0.1 µM of phorbol 12‑myristate 13‑acetate, 50 µM of U 73122, 100 µM of carbachol and 10 µM of MK801 were ineffective in the anesthetic‑induced decrease in CREB phosphorylation. Intravenous anesthetics markedly decreased CREB phosphorylation in the mouse hippocampus, which was most likely via the protein kinase C and mitogen activated protein kinase pathways. This suggests that CREB represents a target for anesthetic action in the brain.

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Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm

Cited by 14 publications

References 27 publications

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

Involvement of pCREB Expression in Inhibitory Effects of Coptis japonica on Morphine-induced Psychological Dependence

Effects of intravenous anesthetics on the phosphorylation of cAMP response element‑binding protein in hippocampal slices of adult mice

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