Oil-In-Water Microemulsion Liquid Chromatography

Peris-García, E.; Pankajkumar-Patel, N.; Ruiz-Ángel, M.J.; Carda‐Broch, Samuel; Garcı́a-Alvarez-Coque, M.C.

doi:10.1080/15422119.2018.1524386

Cited by 15 publications

(6 citation statements)

References 86 publications

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“…Table 3 indicates that with the increase in R-SH intensity, the d 50 of emulsion keeps getting smaller, and the d 90 of emulsion initially decreases and then increases. In this context, Jafari et al pointed out that the emulsion droplet size could not be reduced with energy input below a certain size [39] . Thus, continuing to input energy might be inefficient or sometimes could increase the emulsion droplet size because of poor stabilization of the newly formed droplets.…”

Section: Resultsmentioning

confidence: 99%

Pickering emulsion prepared by nano-silica particles – A comparative study for exploring the effect of various mechanical methods

Gao

Zhou

et al. 2022

Ultrasonics Sonochemistry

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Section: Resultsmentioning

confidence: 99%

Pickering emulsion prepared by nano-silica particles – A comparative study for exploring the effect of various mechanical methods

Gao

Zhou

et al. 2022

Ultrasonics Sonochemistry

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“…Lipophilic compounds like the investigated pharmaceuticals will penetrate and dissolve into micelle's core which is now more hydrophobic, through the interaction of oil droplets with nonpolar tail of micelles. It is well established that hydrophobic drugs analysed by MELC undergo enhanced mass transfer from the lipophilic core of the micelles to the stationary phase, resulting in rapid elution of drugs [27]. Consequently, ARP, PRM and PRB are postulated to reside within the…”

Section: Studying the Suitability Of Mlc Hmlc And Melc For Experimental Determination Of Log P M/wmentioning

confidence: 99%

“…It is to be noted that in spite that the lipophilicity of ARP > PRM > PRB as reflected from their reported log P values [23], their elution order is reversed applying the three mobile phases. This retention attitude could be ascribed to mass transfer which is a unique phenomenon experienced by lipophilic drugs analysed by micelle-based mobile phases [25][26][27]. The main mechanism involved is the transport of highly lipophilic drugs from micelles to stationary phase, resulting in a remarkable reduction in their retention times.…”

Section: Separation Parameters Optimizationmentioning

confidence: 99%

“…8: 202371 the other hand, when MELC was used, the experimentally resultant log P m/w values were lower than expected (figure 2c and table 2); this outcome can be interpreted by understanding the potential retention behaviour in MELC. In MELC, the nano-diameter of the oil droplets (less than 10 nm) yields a remarkable interfacial area accompanied with enhanced interactions [27]. The droplets are included within the micelles in the solution, and acquire the same negative charge carried by the surfactant heads [27].…”

Section: Studying the Suitability Of Mlc Hmlc And Melc For Experimental Determination Of Log P M/wmentioning

confidence: 99%

“…In MELC, the nano-diameter of the oil droplets (less than 10 nm) yields a remarkable interfacial area accompanied with enhanced interactions [27]. The droplets are included within the micelles in the solution, and acquire the same negative charge carried by the surfactant heads [27]. Lipophilic compounds like the investigated pharmaceuticals will penetrate and dissolve into micelle's core which is now more hydrophobic, through the interaction of oil droplets with nonpolar tail of micelles.…”

Section: Studying the Suitability Of Mlc Hmlc And Melc For Experimental Determination Of Log P M/wmentioning

confidence: 99%

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Studying the suitability of hybrid micelle liquid chromatography for estimating the lipophilicity of some partial dopamine agonists used to attain the reward circuit

2021

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Three micellar-based mobile phases were developed and optimized for the simultaneous determination of certain partial dopamine agonists that are used to overcome the withdrawal symptoms of abused drugs, namely aripiprazole, pramipexole and piribedil. The studied drugs were separated using micellar liquid chromatography, hybrid micellar liquid chromatography (HMLC) and microemulsion liquid chromatography (MELC). The three developed mobile phases were studied to estimate their suitability for the measurement of log p -values of the studied drugs. Experimental determination of log P m/w values using the three mobile phases demonstrates that HMLC is the mobile phase of choice since the obtained practical log P m/w values were in accordance with the reported log P values, and calculated log P and log D values. An explanation of the obtained results was presented based on the separation retention mechanism for each chromatographic technique. Furthermore, the effect of the pH and the column temperature in HMLC on the practical log P m/w values was studied. To verify its suitability for experimental measurement of log P m/w , HMLC was subjected to full validation according to the United States Pharmacopeia.

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Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review

Ebrahimi,

Icoz,

Didarian

et al. 2023

Adv Materials Inter

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Separation and identification of molecules and biomolecules such as nucleic acids, proteins, and polysaccharides from complex fluids are known to be important due to unmet needs in various applications. Generally, many different separation techniques, including chromatography, electrophoresis, and magnetophoresis, have been developed to identify the target molecules precisely. However, these techniques are expensive and time consuming. “Lab‐on‐a‐chip” systems with low cost per device, quick analysis capabilities, and minimal sample consumption seem to be ideal candidates for separating particles, cells, blood samples, and molecules. From this perspective, different microfluidic‐based techniques have been extensively developed in the past two decades to separate samples with different origins. In this review, “lab‐on‐a‐chip” methods by passive, active, and hybrid approaches for the separation of biomolecules developed in the past decade are comprehensively discussed. Due to the wide variety in the field, it will be impossible to cover every facet of the subject. Therefore, this review paper covers passive and active methods generally used for biomolecule separation. Then, an investigation of the combined sophisticated methods is highlighted. The spotlight also will be shined on the elegance of separation successes in recent years, and the remainder of the article explores how these permit the development of novel techniques.

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Oil-In-Water Microemulsion Liquid Chromatography

Cited by 15 publications

References 86 publications

Pickering emulsion prepared by nano-silica particles – A comparative study for exploring the effect of various mechanical methods

Pickering emulsion prepared by nano-silica particles – A comparative study for exploring the effect of various mechanical methods

Studying the suitability of hybrid micelle liquid chromatography for estimating the lipophilicity of some partial dopamine agonists used to attain the reward circuit

Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review

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