Oil of Peppermint as a Local Anæsthetic.

Wright, Alfred

doi:10.1016/s0140-6736(02)60091-1

Cited by 14 publications

(13 citation statements)

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“…In fact, menthol is classified by the US Food and Drug Administration as a topical analgesic [12]. An analgesic effect in neuropathic pain had already been reported by Wright in 1870 [13], who described pain relief with peppermint oil in patients with “facial neuralgia.” Further, Davies et al. [14] successfully treated a patient with postherpetic neuralgia with topical menthol.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Menthol on Cold Allodynia in Patients with Neuropathic Pain

Wasner¹,

Naleschinski²,

Binder³

et al. 2008

Pain Med

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Section: Discussionmentioning

confidence: 99%

The Effect of Menthol on Cold Allodynia in Patients with Neuropathic Pain

Wasner¹,

Naleschinski²,

Binder³

et al. 2008

Pain Med

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“…• A thorough overview and an evaluation of the results obtained when applying L-menthol topically as a pain model. and pruritus (Wright, 1870;Anand, 2003). L-menthol is readily absorbed upon inhalation, sublingual, oral or topical administration, metabolized to menthol glucuronide in the liver and subsequently excreted in the urine.…”

Section: What Does This Study Add?mentioning

confidence: 99%

“…L‐menthol is a small cyclic terpene that can be extracted from natural sources, such as Mentha arvensis , or chemically synthesized (Bharate and Bharate, ). It has been utilized historically in low concentrations as an analgesic with indications such as PHN and pruritus (Wright, ; Anand, ). L‐menthol is readily absorbed upon inhalation, sublingual, oral or topical administration, metabolized to menthol glucuronide in the liver and subsequently excreted in the urine.…”

Section: Introductionmentioning

confidence: 99%

A review of topical high‐concentration L‐menthol as a translational model of cold allodynia and hyperalgesia

Andersen

Olsen

Møller

et al. 2013

European Journal of Pain

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Background: Cold allodynia and cold hyperalgesia are both elusive features of neuropathic pain, particularly in patients with various polyneuropathies. Numerous studies have suggested that topical application of L-menthol causes temporary cold hypersensitivity and thus acts as a proxy for associated symptoms. This review summarizes studies on L-menthol-induced nociception, cold allodynia and cold hyperalgesia in vitro, in animals and in humans. Methods: A comprehensive literature search was performed using the PubMed and Google Scholar databases until February 2013. Obtained manuscripts were reviewed for relevancy and reference lists of the retrieved articles were cross-checked for additional important studies. Solely the literature regarding topical application of L-menthol in humans was attained systematically. Of the total identified studies (96), 10 met the inclusion criteria being controlled studies applying L-menthol at a concentration of ≥30%. Results: The extracted data are meticulously compared and presented with emphasis on clarity and transparency. In seven animal studies, cold allodynia or hyperalgesia was successfully established utilizing various methods. Eight studies in healthy volunteers unanimously reported a significant increase in cold pain threshold, representing cold allodynia and increased supra-threshold cold pain sensitivity, thus demonstrating cold hyperalgesia. Conclusions: Topical high-concentration L-menthol consistently induces cold hypersensitivity in animals and humans, thus constituting a predictable surrogate model of cold allodynia and hyperalgesia. Understanding translational features of this model and its underlying mechanisms could be valuable in preclinical and human phases of drug development and in improving current treatment of patients with polyneuropathy.

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“…He observed that topical ointment with peppermint oil (containing L-menthol) reduced pain in patients suffering from post-herpetic neuralgia and several studies have since substantiated the claim. 15,19,39,44,45,65 Today, L-menthol is widely used in ointments to counteract local inflammation, eczema and joint aches, in lozenges to relieve throat soreness and also in nasal sprays to decongest and de-inflame the upper airways in case of common colds and fl. Moreover, FDA has listed L-menthol as a local anesthetic, antipruritic and antitussive compound.…”

Section: Introductionmentioning

confidence: 99%

High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde

Andersen

Gazerani

Arendt-Nielsen

2016

The Journal of Pain

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Drugs interacting with transient receptor potential channels are of great therapeutic potential. In the present study we established cutaneous pain and hyperalgesia using the TRPA1 agonist CA. Subsequently, we showed that the frequently used topical counterirritant and TRPM8 agonist, L-menthol, decreased evoked pain, hyperalgesia, and inflammation, indicating direct and indirect antinociceptive mechanisms.

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Oil of Peppermint as a Local Anæsthetic.

Cited by 14 publications

References 0 publications

The Effect of Menthol on Cold Allodynia in Patients with Neuropathic Pain

The Effect of Menthol on Cold Allodynia in Patients with Neuropathic Pain

A review of topical high‐concentration L‐menthol as a translational model of cold allodynia and hyperalgesia

High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde

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