The complicated fault-block reservoir is a particular reservoir all over the world, but it is widely distributed in eastern China. Complicated fault-block reservoirs have a particular complex structure and reservoir and fluid feature. So there are different change tendencies of the watercut of single well. Based on the geological character of complicated fault-block reservoir, the authors figure out the factors affecting watercut of single well, mainly including water saturation of producing interval, sealing fault and associated fractures, interlayer heterogeneity, plane heterogeneity, injection/production ratio, and hydrocarbon viscosity. Then by applying a numerical simulation method, an appropriate simulation model of flooding unit is established. The results show that the factors mentioned have a close impact on watercut of single well. But the extent of influence is different.