OIP5, a target of miR-15b-5p, regulates hepatocellular carcinoma growth and metastasis through the AKT/mTORC1 and β-catenin signaling pathways

Li, Hua; Zhang, Jun; Lee, Mi-Jin; Yu, Goung-Ran; Han, Xue-Ji; Kim, Dae‐Ghon

doi:10.18632/oncotarget.15185

Cited by 41 publications

(36 citation statements)

References 39 publications

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“…miR-15b-5p was found down-regulated in HCC cells and OIP5 was found to be its direct target. These findings suggest that the restoration of miR-15b-5p could inhibit OIP5-mediated oncogenic signaling in HCC[ 33 ].…”

Section: Mirnas In Hcc Molecular Pathwaysmentioning

confidence: 99%

Role of microRNAs in the main molecular pathways of hepatocellular carcinoma

Vasuri

Visani

Acquaviva

et al. 2018

WJG

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Hepatocellular carcinoma (HCC) is the most common primary liver malignant neoplasia. HCC is characterized by a poor prognosis. The need to find new molecular markers for its diagnosis and prognosis has led to a progressive increase in the number of scientific studies on this topic. MicroRNAs (miRNAs) are small non-coding RNA that play a role in almost all main cellular pathways. miRNAs are involved in the regulation of expression of the major tumor-related genes in carcinogenesis, acting as oncogenes or tumor suppressor genes. The aim of this review was to identify papers published in 2017 investigating the role of miRNAs in HCC tumorigenesis. miRNAs were classified according to their role in the main molecular pathways involved in HCC tumorigenesis: (1) mTOR; (2) Wnt; (3) JAK/STAT; (4) apoptosis; and (5) MAPK. The role of miRNAs in prognosis/response prediction was taken into consideration. Bearing in mind that the analysis of miRNAs in serum and other body fluids would be crucial for clinical management, the role of circulating miRNAs in HCC patients was also investigated. The most represented miRNA-regulated pathway in HCC is mTOR, but apoptosis, Wnt, JAK/STAT or MAPK pathways are also influenced by miRNA expression levels. These miRNAs could thus be used in clinical practice as diagnostic, prognostic or therapeutic targets for HCC treatment.

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Section: Mirnas In Hcc Molecular Pathwaysmentioning

confidence: 99%

Role of microRNAs in the main molecular pathways of hepatocellular carcinoma

Vasuri

Visani

Acquaviva

et al. 2018

WJG

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“…Investigation of the mechanisms underlying the regulation of breast cancer by miRNAs is essential (9). The miRNA miR-15b-5p, a mature miRNA which is spliced from the 5 ′ -end of pre-miR-15b (10), has been reported to be expressed in many cancers, including gastric cancer (11), colorectal cancer (12), prostate cancer (13), bladder cancer (14), and hepatocellular carcinoma (15). In these tumors, miR-15b-5p promotes proliferation, decreases apoptosis, induces tumor metastasis and recurrence, and is associated with poor patient prognosis.…”

Section: Introductionmentioning

confidence: 99%

miR-15b-5p Promotes Growth and Metastasis in Breast Cancer by Targeting HPSE2

Liu

Jin

et al. 2020

Front. Oncol.

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MicroRNAs (miRNAs) can participate in many behaviors of various tumors. Prior studies have reported that miR-15b-5p in different tumors can either promote or inhibit tumor progression. In breast cancer, the role of miR-15b-5p is unclear. The main objective of this paper is to explore miR-15b-5p effects and their mechanisms in breast cancer using both in vitro and in vivo experiments. This study showed that miR-15b-5p expression was upregulated in breast cancer compared with normal breast tissue and was positively correlated with poor overall survival in patients. Knockdown of miR-15b-5p in MCF-7 and MD-MBA-231 breast cancer cells restrained cell growth and invasiveness and induced apoptosis, whereas overexpression of miR-15b-5p achieved the opposite effects. We next revealed a negative correlation between miR-15b-5p and heparanase-2 (HPSE2) expression in breast cancer. Knockdown of miR-15b-5p significantly increased HPSE2 expression at both mRNA and protein levels in breast cancer cells in vitro. The underlying mechanisms of miR-15-5p in breast cancer were investigated using luciferase activity reporter assay and rescue experiments. In addition, miR-15b-5p knockdown significantly inhibited tumor growth in a xenograft model in mice. In summary, we showed that miR-15b-5p promotes breast cancer cell proliferation, migration, and invasion by directly targeting HPSE2. Accordingly, miR-15b-5p may serve both as a tool for prognosis and as a target for therapy of breast cancer patients.

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“…For example, it has been reported that miR-212 suppresses tumor growth of HCC by targeting forkhead box protein A1 (FOXA1) [ 7 ]. And miR-15b-5p regulates HCC growth and metastasis through the AKT/mTORC1 and β-catenin signaling pathways [ 8 ]. Recently, Liu C et al reported that miR-324-3p could modulate cancer cell growth and apoptosis by targeting SMAD family member 7 (SMAD7) in nasopharyngeal carcinoma [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

MiR-324-3p promotes tumor growth through targeting DACT1 and activation of Wnt/β-catenin pathway in hepatocellular carcinoma

Tuo

Wang

et al. 2017

Oncotarget

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Recently, it has been reported that miR-324-3p participates in regulation of the carcinogenesis and tumor progression in various cancers. However, the expression and function of miR-324-3p in hepatocellular carcinoma (HCC) remain unclear. In the current study, miR-324-3p expression was significantly up-regulated in HCC tissues and cell lines. HCC patients with high miR-324-3p level showed poor prognostic features and shorter overall survival and disease-free survival. And in vitro and in vivo experiments revealed that miR-324-3p promoted cell viability, colony formation, proliferation and cell cycle progression of HCC cells. Further studies demonstrated that miR-324-3p could directly target DACT1 (dishevelled binding antagonist of beta catenin 1) and negatively regulated its expression in HCC cells. And rescue experiments revealed that DACT1 could reverse the effects of miR-324-3p on HCC cells. Furthermore, the accumulation of both cytoplasmic and nuclear β-catenin as well as its downstream targets including c-Myc and cyclin D1 could be positively regulated by miR-324-3p. The regulatory effects of miR-324-3p on β-catenin, c-Myc and cyclin D1 levels could be reversed by DACT1. Overall, we concluded that miR-324-3p could promote tumor growth through targeting DACT1 and activation of Wnt/β-catenin pathway in HCC. MiR-324-3p may be a ponderable and promising therapeutic target for HCC.

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OIP5, a target of miR-15b-5p, regulates hepatocellular carcinoma growth and metastasis through the AKT/mTORC1 and β-catenin signaling pathways

Cited by 41 publications

References 39 publications

Role of microRNAs in the main molecular pathways of hepatocellular carcinoma

Role of microRNAs in the main molecular pathways of hepatocellular carcinoma

miR-15b-5p Promotes Growth and Metastasis in Breast Cancer by Targeting HPSE2

MiR-324-3p promotes tumor growth through targeting DACT1 and activation of Wnt/β-catenin pathway in hepatocellular carcinoma

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