OK‐432 Sclerotherapy in Head and Neck Lymphangiomas: Long‐term follow‐up Result

Yoo, Jae Chul; Ahn, Youngjin; Lim, Yune Syung; Hah, J. Hun; Kwon, Taekyoung; Sung, Myung‐Whun; Kim, Kwang Hyun

doi:10.1016/j.otohns.2008.10.026

Cited by 62 publications

(47 citation statements)

References 11 publications

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“…3 Özellikle bleomisin ve picibanil (OK-432) enjeksiyonlarının yaygın kullanımı mevcuttur. Bleomisin antineoplastik etkisini DNA sentezini inhibe ederek gösteren anti-tümör bir ajandır ve yan etkisi oldukça azdır.…”

Section: Discussionunclassified

“…Son yıllarda kullanılan yeni tedavi seçenekleri arasında öne çıkan bleomisin ve picibanil (OK-432) gibi sklerozan ajanların intralezyonel enjeksiyonları ile başarılı sonuçlar bildirilmektedir. 3 Özellikle bleomisin yaygın olarak kullanılmaktadır ve yan etkisi oldukça azdır. Lenfanjiyom ani solunum sıkıntısına yol açması yönüyle de önem taşımaktadır.…”

Section: Introductionunclassified

See 1 more Smart Citation

A Rare Diagnosis in an Infant with Upper Airway Obstruction: Lymphangioma

Aslan¹,

Arslan²,

Horoz³

et al. 2017

cayd

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GirişLenfanjiyom, lenfatik sistemin doğuştan malformasyonudur ve yenidoğan döneminde baş ve boyun bölgesinin en sık görülen doğuştan kistik malformasyonlardan biridir.1 Lenfatik damarlarla venöz sistem arasında nedeni bilinmeyen bir nedenle bağlantının oluşmaması sonucu gelişir. Çocukluk çağının en sık görülen ikinci benign vasküler tümörüdür ve %50'si doğumda %90'ı da 2 yaşın altında tanı alır.2 Uzun yıllar temel tedavi olarak cerrahi eksizyon uygulanmasına rağmen komşuluğundaki önemli anatomik dokulara invaze olduğunda eksizyonu zordur ve nüks, skar, enfeksiyon gibi komplikasyonlarından dolayı seçenek tedavi arayışlarına neden olmuştur. Son yıllarda kullanılan yeni tedavi seçenekleri arasında öne çıkan bleomisin ve picibanil (OK-432) gibi sklerozan ajanların intralezyonel enjeksiyonları ile başarılı sonuçlar bildirilmektedir.3 Özellikle bleomisin yaygın olarak kullanılmaktadır ve yan etkisi oldukça azdır. Lenfanjiyom ani solunum sıkıntısına yol açması yönüyle de önem taşımaktadır. Biz burada üst hava yolu obstrüksiyonu nedeni ile başvurup acil trakeostomi açılan olguyu sunduk ve zor havayoluna yol açan bu nadir nedene ve cerrahiye seçenek olan tedavi yöntemlerine dikkat çekmek istedik.

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Section: Discussionunclassified

Section: Introductionunclassified

A Rare Diagnosis in an Infant with Upper Airway Obstruction: Lymphangioma

Aslan¹,

Arslan²,

Horoz³

et al. 2017

cayd

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“…반복된 경화요 법 이후에 수술을 시행하는 경우에는 주변 조직과의 유착 및 출혈로 수술 중 어려움을 겪을 수 있다 [8]. 여기에서는 수술 적 치료를 우선적으로 시행하였던 두경부 림프관종의 경우 들에 대한 삼성서울병원의 사례를 살펴보고 수술 이후 현재 까지의 결과를 평가하였다.…”

Section: Journal Of Korean Association Of Pediatric Surgeonsunclassified

Surgical Treatment of Difficult Cervicofacial Lymphangioma in Children

Hwang

Lee

Lim

et al. 2015

J Korean Assoc Pediatr Surg

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Purpose: Cervical lymphangiomas are rare lymphovascular malformations arising in the neck, which form huge fluid-containing cysts. Treatment of the malformation consists of surgery and sclerotherapy. However, the optimal approach is still controversial. Here, we describe a series of cervical lymphangiomas which have been treated with surgical approaches. Methods: We retrospectively investigated the medical records of 82 patients who had been diagnosed with cervicofacial lymphangioma from 2001 to 2012 in our center. A closed suction drainage with negative pressure was placed on the operative lesion following excision to prevent reaccumulation of lymphatic fluid and the drainage tube was removed after injecting OK-432 through the tube. Results: Twelve patients underwent surgical excision of cervical lymphangioma. The median patient age was 3 months at the time of the operation. The patients have been followed-up over a period of 34 months. When lesions were located near vital organs such as the trachea or carotid artery or did not respond to repetitive OK-432 injections, surgical treatment might bring good outcomes. However, swallowing difficulty, lip palsy, or dyslalia due to adjacent nerve damage temporarily appeared as postoperative complications. Five children had tracheostomy due to tracheal or subglottic stenosis and 2 patients had gastrostomy due to aspiration while they eat after surgery. Conclusion: Surgery for cervicofacial lymphangioma should be conducted carefully in selective cases. A well thought-out surgical plan with a multidisciplinary surgical team approach and placement of closed suction drainage tube after surgery and adjuvant OK-432 sclerotherapy through drainage tube seem to be helpful for good outcome.

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“…A regression of lymphangiomas after OK-432 therapy is reported in up to 96% of the patients. 9 Yoo et al 38 reported an initial response rate of 83.5% and long-term response rate of 76.3% after treatment with OK-432 of 55 patients with head and neck lymphangiomas.…”

Section: Ok-432mentioning

confidence: 99%

Sclerotherapy of lymphangiomas of the head and neck

Wiegand¹,

Eivazi²,

Zimmermann³

et al. 2010

Head & Neck

106

104

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Lymphangiomas are congenital malformations of the lymphatic system that consist of cysts of varying size. Although they are benign, they can undergo progressive growth with compression and infiltration of adjacent structures. Surgical excision has been the cornerstone of treatment, although total excision of the lymphangioma can be a major challenge and may be associated with severe complications. Therefore, a variety of nonsurgical methods have been proposed to reduce the surgical morbidity and to decrease the recurrence rate. Percutaneous sclerotherapy of lymphangioma involves the injection of sclerosing substances into the lymphangioma cysts. During the past years, different sclerosants and sclerosant techniques have been developed. This review summarizes the current knowledge on sclerotherapy of lymphangiomas of the head and neck.

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OK‐432 Sclerotherapy in Head and Neck Lymphangiomas: Long‐term follow‐up Result

Abstract: Initial and the long-term response rate were equally good for lymphangioma.

Cited by 62 publications

References 11 publications

A Rare Diagnosis in an Infant with Upper Airway Obstruction: Lymphangioma

A Rare Diagnosis in an Infant with Upper Airway Obstruction: Lymphangioma

Surgical Treatment of Difficult Cervicofacial Lymphangioma in Children

Sclerotherapy of lymphangiomas of the head and neck

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