OK-432 therapy for lymphangioma in children: Why and how does it work?

Prenatal diagnosis of fetal abdominal lymphangioma by ultrasonography

“…Many adjunctive therapies for treatment of lymphangioma have been described with varying results. Successful outcomes have been reported following the use of intralesional Bleomycin, sclerotherapy with OK432 or percutaneous embolization with Ethibloc [15][16][17] . Local injection of fibrin glue and laser photocoagulation have been used for postnatal treatment 18,19 .…”

A case of chylothorax treated curatively with Sapylin, a streptococcus preparation

“…The streptococcus preparations can activate natural killer cells and T cells, as well as inducing the production of cytokines such as tumor necrosis factor, interleukin-6, vascular endothelial growth factor and transforming growth factor β 1 . Therefore, the intrathoracic injection of these agents promotes the development of fibrin clots, and this is thought to facilitate pleurodes (Ogita et al, 1996;Fujino et al, 2003). Sapylin/OK-432 produces an inflammatory reaction leading to the destruction of the epithelial lining and the subsequent sclerosis and cicatricial contraction of the lesion, too.…”

Treatment guideline for hemangiomas and vascular malformations of the head and neck

“…Ethanol was the most common sclerosing agent used in the past, followed by doxycycline, sodium tetradecyl sulfate (STS), 40 and OK-432. 41 Response varied with the type of lymphatic malformation, with 100%, 86%, and 43% of the patients reporting good to complete response for macrocystic, microcystic, and combined-type lymphatic malformations, respectively.…”