OK‐432 Therapy for Recalcitrant Warts

Abstract

Twelve patients with warts recalcitrant to various treatment, including cryotherapy, were treated with OK-432 injection therapy. Six patients received only subcutaneous injection, three received only intralesional injection, and the other three received both subcutaneous and intralesional injections. Complete clearing of the warts occurred in nine (75%) of 12 patients, while the other three patients were not cured. Grouping the patients by the method of injection, the success rate of subcutaneous injection was 5/9 (55.6%), and that of intralesional injection was 4/6 (66.7%). Although five patients complained of mild fever and malaise, these side effects gradually disappeared during the repeated injections. OK-432 injection is considered as a hopeful therapy for recalcitrant warts.

Angiosarcoma of the scalp treated with OK‐432 and rIL‐2

“…This drug improves the prognosis of malignant tumors, such as oral squamous cell carcinoma and uterine cervical cancer, combined with other antitumor agents 2,3 . Dermatologically, OK‐432 is also applied to recalcitrant warts, and to bowenoid papulosis and molluscum contagiosum in immunosuppressed adults 5–7 …”

What's New in the Treatment of Viral Warts in Children

“…During the 1970s, local injection of OK‐432 was reported in the Japanese literature to be effective for the treatment of warts. More recently, Inui et al (51) have reported a cure rate of 75% in 12 patients, including older children with warts, by once a week intralesional or subcutaneous injections of OK‐432. OK‐432 is a penicillin‐ and heat‐treated lyophilized powder of the substrain of Streptococcus pyogenes A3.…”

Therapeutic effects of streptococcal preparation OK-432 on atopic dermatitis-like lesions in NC/Nga mice: possible shift from a Th2- to Th1-predominance

“…The streptococcal preparation, OK-432, a penicillin-inactivated and lyphophilized preparation of the low-virulence strain, Su Streptococcus pyogenes, has been shown to have immunomodulatory and possibly therapeutic properties [13,14]. This preparation has also been found a potent inducer of IL-12 [15].…”