Olanzapine has poorer efficacy than risperidone for the treatment of the negative symptoms of schizophrenia

Vadlamani, Laxmi Naresh; Banwari, Girish; Dinakaran, Damodharan; Menon, Vikas; Andrade, Chittaranjan

doi:10.4103/psychiatry.indianjpsychiatry_95_17

Cited by 2 publications

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“…It is a typical drug for the treatment of schizophrenia. 16 Schizophrenia has positive and negative symptoms. Olanzapine is mainly used in the treatment of mental illness with positive symptoms and the maintenance treatment of secondary emotional symptoms in the acute phase.…”

Section: Discussionmentioning

confidence: 99%

Paroxetine combined with olanzapine in the treatment of schizophrenia

et al. 2020

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Objective: To investigate the clinical efficacy of paroxetine combined with olanzapine in the treatment of senile schizophrenia with depression. Methods: Eighty-four elderly schizophrenic patients with depression who were admitted to our hospital from August 2016 to February 2018 were selected as research subjects and randomly divided into observation group and control group using random number table, 42 cases in each group. The control group was treated with olanzapine orally, while the observation group was treated with olanzapine and paroxetine orally. The level of homocysteine (Hcy) in the two groups was analyzed before and after treatment. The efficacy was evaluated by the Positive and Negative Symptoms Scale (PANSS) score and Hamilton Depression Scale (HAMD) score. The adverse reactions of the two groups were compared. Results: After treatment, the level of serum Hcy in the observation group was significantly lower than that in the control group (P<0.05), and it was close to the normal level. There was no significant difference in PANSS score between the two groups before treatment (P>0.05). After treatment, the negative factor score and PANSS score in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). The HAMD score of the two groups had no significant difference before treatment (P>0.05). After treatment, the HAMD score of the observation group was significantly lower than that of the control group (P<0.05). The difference of incidence of adverse reactions between the two groups had no statistical significance (P>0.05). Conclusion: Paroxetine combined with olanzapine has a definite clinical effect in the treatment of senile schizophrenia with depression. It can effectively reduce the level of serum Hcy, relieve the symptoms of schizophrenia, and alleviate the depressive symptoms of patients, with high safety. It is worth promoting. doi: https://doi.org/10.12669/pjms.36.3.846 How to cite this:Wang N, Zheng N, Dong M, He J. Paroxetine combined with olanzapine in the treatment of schizophrenia. Pak J Med Sci. 2020;36(3):---------. doi: https://doi.org/10.12669/pjms.36.3.846 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%