OLANZAPINE REDUCES PSYCHOSIS AND BEHAVIORAL SYMPTOMS ASSOCIATED WITH ALZHEIMER's DISEASE

Gender, aggression and serotonergic function are associated with response to sertraline for behavioral disturbances in Alzheimer's disease

“…Since each subscale on the NPI is scored from 0 to 12, a change of 4 points is roughly equivalent to a given behaviour decreasing by 25%, or a very frequent behaviour (essentially continuously present) going from the most severe category (marked) to moderate in severity (Cummings et al, 1994). The NPI has demonstrated that it is sensitive enough to detect changes in BPSD resulting from pharmacotherapy with tacrine (Kaufer et al, 1996), metrifonate (Kaufer, 1998), donepezil (Mega et al, 1996) and olanzapine (Street et al, 1999).…”

Pharmacotherapy of Behavioral and Psychological Symptoms of Dementia: Time for a Different Paradigm?

“…Preliminary findings from the first randomized, controlled trial confirmed olanzapine' s efficacy. 44 Olanzapine 5 and 10 mg significantly improved symptoms of psychosis and other behaviors compared with placebo in 206 patients with AD over 6 weeks. Response, defined as a 50% improvement in NPI aggression, hallucinations, and delusions, was 58-67%.…”

“…The scale is sensitive enough to detect changes resulting from pharmacotherapy. Trials evaluating the efficacy of metrifonate, 42 donepezil, 43 and olanzapine 44 for BPSD used this scale.…”

“…[55][56][57][58][59][60][61] It still is being used in trials of atypical antipsychotics such as olanzapine and quetiapine. 44,48,62 Outcomes Do some behavioral symptoms predict the onset of other behavioral symptoms? A longitudinal study that evaluated subjects every 4 months observed that apparent sadness predicted physical aggression over 4 years of follow-up, and persecutory ideas predicted hyperactivity.…”