Olaparib nanoparticles potentiated radiosensitization effects on lung cancer

Wu, Min; Liu, Jing; Hu, Chuanfei; Li, Dong; Yang, Juan; Wu, Zhi‐Ying; Yang, Linglin; Chen, Yue; Shao, Fu; Wu, Jingbo

doi:10.2147/ijn.s181546

Cited by 31 publications

(25 citation statements)

References 45 publications

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“…[131] The ATM and ATR kinase signaling cascades are also initiated. [104] The DNA repair can be hindered, for example, by using PARP inhibitors [132,133] or by knocking down PARP expression with siRNA, which may be delivered by using NPs. [134] Such blocking of DNA repair enhances the effectiveness of ROS generated by limited radiation doses.…”

Section: Cellular Repair Of Radiation-induced Dna Damagementioning

confidence: 99%

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

et al. 2020

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Engineered nanomaterials that produce reactive oxygen species on exposure to X‐ and gamma‐rays used in radiation therapy offer promise of novel cancer treatment strategies. Similar to photodynamic therapy but suitable for large and deep tumors, this new approach where nanomaterials acting as sensitizing agents are combined with clinical radiation can be effective at well‐tolerated low radiation doses. Suitably engineered nanomaterials can enhance cancer radiotherapy by increasing the tumor selectivity and decreasing side effects. Additionally, the nanomaterial platform offers therapeutically valuable functionalities, including molecular targeting, drug/gene delivery, and adaptive responses to trigger drug release. The potential of such nanomaterials to be combined with radiotherapy is widely recognized. In order for further breakthroughs to be made, and to facilitate clinical translation, the applicable principles and fundamentals should be articulated. This review focuses on mechanisms underpinning rational nanomaterial design to enhance radiation therapy, the understanding of which will enable novel ways to optimize its therapeutic efficacy. A roadmap for designing nanomaterials with optimized anticancer performance is also shown and the potential clinical significance and future translation are discussed.

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Section: Cellular Repair Of Radiation-induced Dna Damagementioning

confidence: 99%

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

et al. 2020

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“…Recently, nanotechnology has paved the way towards the development of an innovative cancer therapy platform [33,34]. Owing to the possibility of modification of nanoparticle composition and surface coating, the functions and specificity of nanoparticles could be more flexibly customized [35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Bacterial Genotoxin-Coated Nanoparticles for Radiotherapy Sensitization in Prostate Cancer

Yuan

Lai

et al. 2021

Biomedicines

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Prostate cancer (PCa) is one of the most commonly diagnosed cancers in men and usually becomes refractory because of recurrence and metastasis. CD44, a transmembrane glycoprotein, serves as a receptor for hyaluronic acid (HA). It has been found to be abundantly expressed in cancer stem cells (CSCs) that often exhibit a radioresistant phenotype. Cytolethal distending toxin (CDT), produced by Campylobacter jejuni, is a tripartite genotoxin composed of CdtA, CdtB, and CdtC subunits. Among the three, CdtB acts as a type I deoxyribonuclease (DNase I), which creates DNA double-strand breaks (DSBs). Nanoparticles loaded with antitumor drugs and specific ligands that recognize cancerous cell receptors are promising methods to overcome the therapeutic challenges. In this study, HA-decorated nanoparticle-encapsulated CdtB (HA-CdtB-NPs) were prepared and their targeted therapeutic activity in radioresistant PCa cells was evaluated. Our results showed that HA-CdtB-NPs sensitized radioresistant PCa cells by enhancing DSB and causing G2/M cell-cycle arrest, without affecting the normal prostate epithelial cells. HA-CdtB-NPs possess maximum target specificity and delivery efficiency of CdtB into the nucleus and enhance the effect of radiation in radioresistant PCa cells. These findings demonstrate that HA-CdtB-NPs exert target specificity accompanied with radiomimetic activity and can be developed as an effective strategy against radioresistant PCa.

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“…Recently, nanotechnology has pioneered a bright road towards the development of innovative cancer therapy platform [31,32]. Owing to the possibility of modi cation of nanoparticle composition and surface coating, the functions and speci city of nanoparticles could be more exibly customized [33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Hyaluronic Acid Nanoparticles-encapsulated Bacterial Genotoxin for Targeted Therapy of Radioresistant Prostate Cancer

Chen¹,

Lai²,

Wu³

et al. 2020

Preprint

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Background: Prostate cancer (PCa) is one of the most commonly diagnosed cancers in men and usually becomes refractory because of recurrence and metastasis. CD44, a transmembrane glycoprotein, serves as a receptor for hyaluronic acid (HA) and has been found to be abundantly expressed in cancer stem cells (CSCs) that often exhibit a radioresistant phenotype. Cytolethal distending toxin subunit B (CdtB), produced by Campylobacter jejuni, is a genotoxin acts as a type I deoxyribonuclease (DNase I), which is responsible for creating DNA double-strand breaks (DSBs). Nanoparticles loaded with antitumor drugs and specific ligands that recognize cancerous cell receptors are promising methods to overcome the therapeutic challenges. Results: In this study, PCa cells with DOC-2/DAB2 interactive protein (DAB2IP) knockdown were employed to imitate the CSC with radioresistant phenotype. We further prepared HA-decorated nanoparticles-encapsulated CdtB (HA-CdtB-NPs) and investigated the targeted therapeutic activity in radioresistant PCa cells. Our results showed that HA-CdtB-NPs sensitized radioresistant PCa cells by enhancing DSB and causing G2/M cell-cycle arrest, without affecting the normal prostate epithelial cells. These results demonstrate that HA-CdtB-NPs possess maximum target-specificity and delivery efficiency of CdtB into the nucleus, and enhance the effect of radiation in radioresistant PCa cells. Conclusions: These findings indicate that HA-loaded CdtB nanoparticles exert target-specificity accompanied with radiomimetic activity, which can be developed as an effective agent for overcoming radioresistance in PCa.

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Olaparib nanoparticles potentiated radiosensitization effects on lung cancer

Cited by 31 publications

References 45 publications

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

Bacterial Genotoxin-Coated Nanoparticles for Radiotherapy Sensitization in Prostate Cancer

Hyaluronic Acid Nanoparticles-encapsulated Bacterial Genotoxin for Targeted Therapy of Radioresistant Prostate Cancer

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